Synonym |
CDA |
Species |
Human |
Protein Accession |
P12345 |
Purity |
≥98% |
Endotoxin Level |
<1 EU/μg |
Biological Activity |
Stimulates cell proliferation |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
10 kDa |
Formulation |
Supplied as a lyophilized powder |
Reconstitution |
Reconstitute in water to a concentration of 1 mg/ml |
Storage & Stability |
Store at -20°C upon receipt, stable for up to 6 months at -80°C |
FAQ
What is Caffeoyl dipeptide amide and how does it benefit the skin?
Caffeoyl dipeptide amide is a
synthetic compound that combines the antioxidant properties of caffeic acid with the skin-rejuvenating
benefits of a dipeptide. This unique blend is used primarily in skincare formulations to provide
multifaceted benefits to the skin, including anti-aging effects, protection against oxidative stress,
and improved skin texture. The caffeic acid component is a well-known antioxidant found in coffee and
various plants, which helps protect the skin from environmental damage caused by UV rays and pollution.
This protection reduces the risk of premature aging and the formation of fine lines and wrinkles. By
neutralizing free radicals, caffeic acid helps maintain the integrity of skin cells, promoting a
youthful appearance.
The dipeptide portion of caffeoyl dipeptide amide is crucial for its
skin-rejuvenating properties. Peptides are short chains of amino acids that serve as the building blocks
of proteins, such as collagen and elastin, which are essential for maintaining skin's firmness and
elasticity. As we age, the production of these proteins diminishes, resulting in sagging skin and the
formation of wrinkles. By incorporating dipeptides, caffeoyl dipeptide amide can stimulate the
production of collagen and elastin, helping to firm and plump the skin, reducing the visibility of fine
lines, and improving overall skin texture and tone.
Furthermore, caffeoyl dipeptide amide has
been shown to possess anti-inflammatory properties, which can be beneficial in soothing irritation and
redness in the skin. This makes it an ideal ingredient for individuals with sensitive skin or conditions
such as rosacea and eczema. The reduction of inflammation can also help in calming acne-prone skin,
preventing the formation of new blemishes and promoting a clearer complexion.
In addition to
these benefits, caffeoyl dipeptide amide may also play a role in skin hydration. By strengthening the
skin barrier, it helps to retain moisture, preventing transepidermal water loss and ensuring that the
skin remains hydrated and supple. Proper hydration is critical for maintaining a healthy and youthful
appearance, as dry skin can often lead to increased sensitivity and the accentuation of fine
lines.
Overall, caffeoyl dipeptide amide is a versatile and effective ingredient that addresses
various skin concerns, from aging and inflammation to hydration and texture. By incorporating this
compound into your skincare routine, you can achieve a healthier, more radiant complexion with improved
resilience against environmental stressors.
How should caffeoyl dipeptide amide be incorporated
into a skincare routine for optimal results?
Incorporating caffeoyl dipeptide amide into a
skincare routine can enhance the overall health and appearance of your skin when done correctly. For
optimal results, it's important to consider your skin type and particular needs, as well as the
formulation of the product containing caffeoyl dipeptide amide. Here are some strategies for integrating
this beneficial compound into your daily regimen.
To start, cleanse your skin with a gentle
cleanser to remove impurities, excess oil, and makeup without stripping the skin's natural moisture. A
clean base will ensure that the caffeoyl dipeptide amide can penetrate effectively and work efficiently.
Following cleansing, apply a toner to balance the pH levels of your skin and prepare it for the
application of active ingredients.
Next, apply a serum or treatment product containing caffeoyl
dipeptide amide. Serums are ideal vehicles for the delivery of potent active ingredients due to their
lightweight and fast-absorbing nature. Gently pat the serum onto the skin, focusing on areas of concern
such as fine lines and wrinkles, hyperpigmentation, or areas prone to redness and irritation. Allow the
product to absorb fully before moving on to the next step.
After applying the serum, follow with
a moisturizer suited to your skin type. Moisturizers help seal in the active ingredients and add an
extra layer of hydration, ensuring that the benefits of caffeoyl dipeptide amide are maximized. For
individuals with dry or mature skin, a richer cream may be beneficial, while those with oily or
combination skin may prefer a lighter, water-based lotion.
In the daytime, it is essential to
follow your skincare routine with a broad-spectrum sunscreen. Caffeoyl dipeptide amide offers some
protection against environmental damage, but it should not replace a dedicated sunblock. Using sunscreen
will help prevent further sun damage, which can undermine the anti-aging and protective benefits of
caffeoyl dipeptide amide.
Incorporating caffeoyl dipeptide amide into both morning and evening
routines can be beneficial, but it is also important to listen to your skin. If you notice any
irritation or sensitivity, you may need to adjust the frequency of application or perform a patch test
to ensure compatibility. Consistency is key to achieving optimal results, and over time, regular use can
lead to improved skin elasticity, reduced fine lines, and a more radiant complexion.
Finally,
consider complementing caffeoyl dipeptide amide with other compatible active ingredients, such as
hyaluronic acid for added hydration or niacinamide for enhanced skin barrier function and brightness.
However, avoid combining it with strong acids or retinoids, unless it's confirmed that your formulation
can handle such combinations, as these can cause irritation when used together with some
peptides.
Can caffeoyl dipeptide amide be used in combination with other skincare
ingredients?
Caffeoyl dipeptide amide can be effectively used in combination with a variety of
other skincare ingredients to enhance its benefits and address a broader range of skin concerns.
However, it's important to understand which ingredients complement each other and which might cause
irritations or diminished effects when used together.
Firstly, caffeoyl dipeptide amide works
well alongside hydrating agents such as hyaluronic acid and glycerin. Hyaluronic acid is known for its
exceptional hydrating properties, capable of holding up to 1,000 times its weight in water, thereby
keeping the skin plump and moisturized. When combined with caffeoyl dipeptide amide, it helps maximize
moisture retention, ensuring that the skin is adequately hydrated and the skin barrier is strengthened.
This synergy helps bolster the skin's defense against external aggressors and maintains a smooth and
resilient appearance.
Niacinamide, or vitamin B3, is another ingredient that can be harmoniously
paired with caffeoyl dipeptide amide. Niacinamide offers anti-inflammatory benefits, enhances skin
barrier function, and reduces the appearance of pores and hyperpigmentation. The combination of
niacinamide and caffeoyl dipeptide amide can be particularly effective for those with sensitive or
problematic skin, as it helps calm irritation while promoting a more even skin tone. This duo is gentle
yet effective, making it suitable for daily use without the risk of sensitization.
Antioxidants
are also great companions to caffeoyl dipeptide amide, as they offer additional protection against free
radicals and environmental stress. Ingredients like vitamin C and vitamin E can work synergistically
with caffeoyl dipeptide amide to provide comprehensive antioxidant protection. Vitamin C, in particular,
is known for its brightening properties and ability to stimulate collagen production, further enhancing
the anti-aging benefits of caffeoyl dipeptide amide.
However, caution should be exercised when
using caffeoyl dipeptide amide in combination with strong exfoliating acids (like AHAs and BHAs) or
powerful retinoids. While these ingredients individually offer impressive skin benefits, when used
together, they can lead to increased sensitivity, irritation, or even compromise the efficacy of
peptides. If you wish to incorporate these ingredients into your routine alongside caffeoyl dipeptide
amide, it's advisable to use them at different times of the day or on alternate days.
Conducting
a patch test before integrating multiple active ingredients into your regimen is always wise. Monitor
your skin’s response and adjust usage accordingly. If any redness, stinging, or irritation occurs, it
may be necessary to simplify your routine and slowly reintroduce products one at a time to identify any
incompatible combinations.
Ultimately, when combined thoughtfully, caffeoyl dipeptide amide can
enhance and complement the effectiveness of other skincare ingredients, providing a comprehensive
approach to achieving healthy, radiant skin.
Are there any side effects or precautions associated
with using caffeoyl dipeptide amide in skincare?
Generally, caffeoyl dipeptide amide is
considered safe for topical use in skincare and is well-tolerated by most individuals. However, like any
active ingredient, there are potential side effects and precautions to be aware of to ensure safe and
effective use. Understanding these will help users mitigate any adverse reactions and optimize the
benefits of caffeoyl dipeptide amide for their skin.
The most common side effect associated with
caffeoyl dipeptide amide, as with many skincare ingredients, is skin irritation. This may present as
redness, itching, or mild discomfort, especially in individuals with sensitive skin or those who have
not used peptides or caffeic acid-based products before. To minimize the risk of irritation, it is
advisable to perform a patch test before incorporating any new product into your routine. Apply a small
amount of the product to a discreet area, such as behind the ear or on the inner wrist, and observe for
any adverse reactions over a 24 to 48-hour period.
If you experience irritation, it may be due to
the formulation of the product rather than the caffeoyl dipeptide amide itself. Additional components,
such as fragrances, preservatives, or other active ingredients, could be the culprits. In such cases,
you might consider switching to a formulation that is free from potential irritants, such as
fragrance-free or for sensitive skin versions.
Individuals with specific allergies or skin
conditions should also consult a dermatologist before adding caffeoyl dipeptide amide to their skincare
routine. This is particularly important for people with known allergies to similar compounds or those
with conditions that predispose them to skin sensitivities, such as eczema or rosacea.
Another
precaution to consider is the potential for interactions with other potent actives. As previously
mentioned, using caffeoyl dipeptide amide in combination with strong exfoliating acids or retinoids can
increase the risk of irritation and potentially reduce the effectiveness of the peptides. It is
generally recommended to alternate such products rather than layer them, or use them at different times
of day.
Pregnant or nursing women should also exercise caution and consult healthcare providers
before using new skincare products, including those containing caffeoyl dipeptide amide. While there are
no specific contraindications for this compound, it is always better to err on the side of caution
during such sensitive periods.
Lastly, ensure that you are obtaining products containing caffeoyl
dipeptide amide from reputable brands and manufacturers. This reduces the risk of contamination or
poor-quality formulations which could lead to skin irritation or other undesired effects. Check for
relevant certifications or approvals that guarantee product safety and efficacy.
By taking these
precautions, the likelihood of experiencing side effects from caffeoyl dipeptide amide is low, and users
can enjoy its benefits with greater confidence and peace of mind.
How does caffeoyl dipeptide
amide compare to other anti-aging ingredients like retinoids or vitamin C?
Caffeoyl dipeptide
amide offers unique benefits as an anti-aging ingredient, with a profile that distinguishes it from
other popular active ingredients such as retinoids and vitamin C. Understanding these differences can
help users decide how best to incorporate caffeoyl dipeptide amide into their skincare regimen and how
it might complement or substitute other products.
Retinoids, derivatives of vitamin A, are
renowned for their powerful anti-aging effects. They promote skin cell turnover and enhance collagen
production, leading to reduced fine lines, improved skin texture, and diminished hyperpigmentation.
However, retinoids are also known for their potential to cause irritation, redness, and peeling,
particularly during the initial phase of use while the skin builds tolerance. This can make them
unsuitable for those with sensitive skin or for people seeking a gentler alternative.
Caffeoyl
dipeptide amide, on the other hand, provides anti-aging benefits through a diversified approach. The
dipeptide component stimulates collagen synthesis much like retinoids, promoting skin firmness and
elasticity. At the same time, the caffeic acid component imparts antioxidant properties, helping to
protect and preserve the skin from environmental damage. This makes caffeoyl dipeptide amide a gentler
choice for individuals who experience irritation with retinoids or who are looking for complementary
products to enhance their anti-aging routine without compounding sensitivity.
Vitamin C is
another highly regarded anti-aging ingredient with strong antioxidant capabilities, assisting in the
reduction of fine lines and brightening skin tone by reducing oxidative stress and inhibiting melanin
synthesis. It also supports collagen production, making it particularly effective for promoting firmness
and elasticity. The challenge with vitamin C primarily lies in its stability and potential for causing
irritation, especially at higher concentrations.
Caffeoyl dipeptide amide differs from vitamin C
in its dual-action mechanism, combining antioxidative protection with peptide-driven collagen support.
While caffeoyl dipeptide amide might not offer the same level of skin brightening as vitamin C, it still
provides multifaceted benefits without the stability issues associated with many vitamin C formulations.
Moreover, its gentler nature makes it suitable for a wider range of skin types, including sensitive
skin.
When considering formulation and skin compatibility, caffeoyl dipeptide amide can be a
valuable addition to a comprehensive skincare routine. It can complement the actions of both retinoids
and vitamin C, offering a more rounded approach to anti-aging by addressing the skin's structural
integrity and oxidative protection concurrently.
Ultimately, the choice between these
ingredients—or their combinations—should be based on individual skin type, concerns, and tolerance
levels. While caffeoyl dipeptide amide may not entirely replace retinoids or vitamin C for some users,
it can serve as an alternative or complementary component within a skincare regimen focused on achieving
youthful, resilient, and radiant skin.