Taiy Chemical
Caffeoyl Dipeptide Amide
Synonym CDA
Species Human
Protein Accession P12345
Purity ≥98%
Endotoxin Level <1 EU/μg
Biological Activity Stimulates cell proliferation
Expression System E. coli
Fusion Tag None
Predicted Molecular Mass 10 kDa
Formulation Supplied as a lyophilized powder
Reconstitution Reconstitute in water to a concentration of 1 mg/ml
Storage & Stability Store at -20°C upon receipt, stable for up to 6 months at -80°C
FAQ
What is Caffeoyl dipeptide amide and how does it benefit the skin?

Caffeoyl dipeptide amide is a synthetic compound that combines the antioxidant properties of caffeic acid with the skin-rejuvenating benefits of a dipeptide. This unique blend is used primarily in skincare formulations to provide multifaceted benefits to the skin, including anti-aging effects, protection against oxidative stress, and improved skin texture. The caffeic acid component is a well-known antioxidant found in coffee and various plants, which helps protect the skin from environmental damage caused by UV rays and pollution. This protection reduces the risk of premature aging and the formation of fine lines and wrinkles. By neutralizing free radicals, caffeic acid helps maintain the integrity of skin cells, promoting a youthful appearance.

The dipeptide portion of caffeoyl dipeptide amide is crucial for its skin-rejuvenating properties. Peptides are short chains of amino acids that serve as the building blocks of proteins, such as collagen and elastin, which are essential for maintaining skin's firmness and elasticity. As we age, the production of these proteins diminishes, resulting in sagging skin and the formation of wrinkles. By incorporating dipeptides, caffeoyl dipeptide amide can stimulate the production of collagen and elastin, helping to firm and plump the skin, reducing the visibility of fine lines, and improving overall skin texture and tone.

Furthermore, caffeoyl dipeptide amide has been shown to possess anti-inflammatory properties, which can be beneficial in soothing irritation and redness in the skin. This makes it an ideal ingredient for individuals with sensitive skin or conditions such as rosacea and eczema. The reduction of inflammation can also help in calming acne-prone skin, preventing the formation of new blemishes and promoting a clearer complexion.

In addition to these benefits, caffeoyl dipeptide amide may also play a role in skin hydration. By strengthening the skin barrier, it helps to retain moisture, preventing transepidermal water loss and ensuring that the skin remains hydrated and supple. Proper hydration is critical for maintaining a healthy and youthful appearance, as dry skin can often lead to increased sensitivity and the accentuation of fine lines.

Overall, caffeoyl dipeptide amide is a versatile and effective ingredient that addresses various skin concerns, from aging and inflammation to hydration and texture. By incorporating this compound into your skincare routine, you can achieve a healthier, more radiant complexion with improved resilience against environmental stressors.

How should caffeoyl dipeptide amide be incorporated into a skincare routine for optimal results?

Incorporating caffeoyl dipeptide amide into a skincare routine can enhance the overall health and appearance of your skin when done correctly. For optimal results, it's important to consider your skin type and particular needs, as well as the formulation of the product containing caffeoyl dipeptide amide. Here are some strategies for integrating this beneficial compound into your daily regimen.

To start, cleanse your skin with a gentle cleanser to remove impurities, excess oil, and makeup without stripping the skin's natural moisture. A clean base will ensure that the caffeoyl dipeptide amide can penetrate effectively and work efficiently. Following cleansing, apply a toner to balance the pH levels of your skin and prepare it for the application of active ingredients.

Next, apply a serum or treatment product containing caffeoyl dipeptide amide. Serums are ideal vehicles for the delivery of potent active ingredients due to their lightweight and fast-absorbing nature. Gently pat the serum onto the skin, focusing on areas of concern such as fine lines and wrinkles, hyperpigmentation, or areas prone to redness and irritation. Allow the product to absorb fully before moving on to the next step.

After applying the serum, follow with a moisturizer suited to your skin type. Moisturizers help seal in the active ingredients and add an extra layer of hydration, ensuring that the benefits of caffeoyl dipeptide amide are maximized. For individuals with dry or mature skin, a richer cream may be beneficial, while those with oily or combination skin may prefer a lighter, water-based lotion.

In the daytime, it is essential to follow your skincare routine with a broad-spectrum sunscreen. Caffeoyl dipeptide amide offers some protection against environmental damage, but it should not replace a dedicated sunblock. Using sunscreen will help prevent further sun damage, which can undermine the anti-aging and protective benefits of caffeoyl dipeptide amide.

Incorporating caffeoyl dipeptide amide into both morning and evening routines can be beneficial, but it is also important to listen to your skin. If you notice any irritation or sensitivity, you may need to adjust the frequency of application or perform a patch test to ensure compatibility. Consistency is key to achieving optimal results, and over time, regular use can lead to improved skin elasticity, reduced fine lines, and a more radiant complexion.

Finally, consider complementing caffeoyl dipeptide amide with other compatible active ingredients, such as hyaluronic acid for added hydration or niacinamide for enhanced skin barrier function and brightness. However, avoid combining it with strong acids or retinoids, unless it's confirmed that your formulation can handle such combinations, as these can cause irritation when used together with some peptides.

Can caffeoyl dipeptide amide be used in combination with other skincare ingredients?

Caffeoyl dipeptide amide can be effectively used in combination with a variety of other skincare ingredients to enhance its benefits and address a broader range of skin concerns. However, it's important to understand which ingredients complement each other and which might cause irritations or diminished effects when used together.

Firstly, caffeoyl dipeptide amide works well alongside hydrating agents such as hyaluronic acid and glycerin. Hyaluronic acid is known for its exceptional hydrating properties, capable of holding up to 1,000 times its weight in water, thereby keeping the skin plump and moisturized. When combined with caffeoyl dipeptide amide, it helps maximize moisture retention, ensuring that the skin is adequately hydrated and the skin barrier is strengthened. This synergy helps bolster the skin's defense against external aggressors and maintains a smooth and resilient appearance.

Niacinamide, or vitamin B3, is another ingredient that can be harmoniously paired with caffeoyl dipeptide amide. Niacinamide offers anti-inflammatory benefits, enhances skin barrier function, and reduces the appearance of pores and hyperpigmentation. The combination of niacinamide and caffeoyl dipeptide amide can be particularly effective for those with sensitive or problematic skin, as it helps calm irritation while promoting a more even skin tone. This duo is gentle yet effective, making it suitable for daily use without the risk of sensitization.

Antioxidants are also great companions to caffeoyl dipeptide amide, as they offer additional protection against free radicals and environmental stress. Ingredients like vitamin C and vitamin E can work synergistically with caffeoyl dipeptide amide to provide comprehensive antioxidant protection. Vitamin C, in particular, is known for its brightening properties and ability to stimulate collagen production, further enhancing the anti-aging benefits of caffeoyl dipeptide amide.

However, caution should be exercised when using caffeoyl dipeptide amide in combination with strong exfoliating acids (like AHAs and BHAs) or powerful retinoids. While these ingredients individually offer impressive skin benefits, when used together, they can lead to increased sensitivity, irritation, or even compromise the efficacy of peptides. If you wish to incorporate these ingredients into your routine alongside caffeoyl dipeptide amide, it's advisable to use them at different times of the day or on alternate days.

Conducting a patch test before integrating multiple active ingredients into your regimen is always wise. Monitor your skin’s response and adjust usage accordingly. If any redness, stinging, or irritation occurs, it may be necessary to simplify your routine and slowly reintroduce products one at a time to identify any incompatible combinations.

Ultimately, when combined thoughtfully, caffeoyl dipeptide amide can enhance and complement the effectiveness of other skincare ingredients, providing a comprehensive approach to achieving healthy, radiant skin.

Are there any side effects or precautions associated with using caffeoyl dipeptide amide in skincare?

Generally, caffeoyl dipeptide amide is considered safe for topical use in skincare and is well-tolerated by most individuals. However, like any active ingredient, there are potential side effects and precautions to be aware of to ensure safe and effective use. Understanding these will help users mitigate any adverse reactions and optimize the benefits of caffeoyl dipeptide amide for their skin.

The most common side effect associated with caffeoyl dipeptide amide, as with many skincare ingredients, is skin irritation. This may present as redness, itching, or mild discomfort, especially in individuals with sensitive skin or those who have not used peptides or caffeic acid-based products before. To minimize the risk of irritation, it is advisable to perform a patch test before incorporating any new product into your routine. Apply a small amount of the product to a discreet area, such as behind the ear or on the inner wrist, and observe for any adverse reactions over a 24 to 48-hour period.

If you experience irritation, it may be due to the formulation of the product rather than the caffeoyl dipeptide amide itself. Additional components, such as fragrances, preservatives, or other active ingredients, could be the culprits. In such cases, you might consider switching to a formulation that is free from potential irritants, such as fragrance-free or for sensitive skin versions.

Individuals with specific allergies or skin conditions should also consult a dermatologist before adding caffeoyl dipeptide amide to their skincare routine. This is particularly important for people with known allergies to similar compounds or those with conditions that predispose them to skin sensitivities, such as eczema or rosacea.

Another precaution to consider is the potential for interactions with other potent actives. As previously mentioned, using caffeoyl dipeptide amide in combination with strong exfoliating acids or retinoids can increase the risk of irritation and potentially reduce the effectiveness of the peptides. It is generally recommended to alternate such products rather than layer them, or use them at different times of day.

Pregnant or nursing women should also exercise caution and consult healthcare providers before using new skincare products, including those containing caffeoyl dipeptide amide. While there are no specific contraindications for this compound, it is always better to err on the side of caution during such sensitive periods.

Lastly, ensure that you are obtaining products containing caffeoyl dipeptide amide from reputable brands and manufacturers. This reduces the risk of contamination or poor-quality formulations which could lead to skin irritation or other undesired effects. Check for relevant certifications or approvals that guarantee product safety and efficacy.

By taking these precautions, the likelihood of experiencing side effects from caffeoyl dipeptide amide is low, and users can enjoy its benefits with greater confidence and peace of mind.

How does caffeoyl dipeptide amide compare to other anti-aging ingredients like retinoids or vitamin C?

Caffeoyl dipeptide amide offers unique benefits as an anti-aging ingredient, with a profile that distinguishes it from other popular active ingredients such as retinoids and vitamin C. Understanding these differences can help users decide how best to incorporate caffeoyl dipeptide amide into their skincare regimen and how it might complement or substitute other products.

Retinoids, derivatives of vitamin A, are renowned for their powerful anti-aging effects. They promote skin cell turnover and enhance collagen production, leading to reduced fine lines, improved skin texture, and diminished hyperpigmentation. However, retinoids are also known for their potential to cause irritation, redness, and peeling, particularly during the initial phase of use while the skin builds tolerance. This can make them unsuitable for those with sensitive skin or for people seeking a gentler alternative.

Caffeoyl dipeptide amide, on the other hand, provides anti-aging benefits through a diversified approach. The dipeptide component stimulates collagen synthesis much like retinoids, promoting skin firmness and elasticity. At the same time, the caffeic acid component imparts antioxidant properties, helping to protect and preserve the skin from environmental damage. This makes caffeoyl dipeptide amide a gentler choice for individuals who experience irritation with retinoids or who are looking for complementary products to enhance their anti-aging routine without compounding sensitivity.

Vitamin C is another highly regarded anti-aging ingredient with strong antioxidant capabilities, assisting in the reduction of fine lines and brightening skin tone by reducing oxidative stress and inhibiting melanin synthesis. It also supports collagen production, making it particularly effective for promoting firmness and elasticity. The challenge with vitamin C primarily lies in its stability and potential for causing irritation, especially at higher concentrations.

Caffeoyl dipeptide amide differs from vitamin C in its dual-action mechanism, combining antioxidative protection with peptide-driven collagen support. While caffeoyl dipeptide amide might not offer the same level of skin brightening as vitamin C, it still provides multifaceted benefits without the stability issues associated with many vitamin C formulations. Moreover, its gentler nature makes it suitable for a wider range of skin types, including sensitive skin.

When considering formulation and skin compatibility, caffeoyl dipeptide amide can be a valuable addition to a comprehensive skincare routine. It can complement the actions of both retinoids and vitamin C, offering a more rounded approach to anti-aging by addressing the skin's structural integrity and oxidative protection concurrently.

Ultimately, the choice between these ingredients—or their combinations—should be based on individual skin type, concerns, and tolerance levels. While caffeoyl dipeptide amide may not entirely replace retinoids or vitamin C for some users, it can serve as an alternative or complementary component within a skincare regimen focused on achieving youthful, resilient, and radiant skin.
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