Synonym |
CDP |
Species |
Human |
Protein Accession |
P12345 |
Purity |
≥ 95% |
Endotoxin Level |
< 1.0 EU/μg |
Biological Activity |
Stimulates cell proliferation |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
10 kDa |
Formulation |
Lyophilized |
Reconstitution |
Reconstitute in sterile water |
Storage & Stability |
Store at -20°C upon arrival, stable for up to 1 year |
FAQ
What are the key benefits of using Caffeoyl dipeptide in skincare formulations?
Caffeoyl
dipeptide is gaining traction in the realm of skincare due to its compelling benefits, making it a
significant focus for both consumers and cosmetics developers. One of the most notable advantages is its
ability to provide powerful antioxidant properties. Antioxidants are fundamental in neutralizing free
radicals—unstable molecules that can damage cells—thereby slowing down the signs of aging and reducing
oxidative stress. The unique composition of caffeoyl dipeptide enables it to bind and stabilize these
free radicals more efficiently than many other compounds.
A second benefit lies in its
anti-inflammatory properties. Inflammation is often caused by environmental factors such as pollution or
UV exposure and can manifest as redness, irritation, or acne. Caffeoyl dipeptide helps reduce
inflammation and calm irritated skin, which can lead to a more even skin tone and texture. By addressing
inflammation, it aids in minimizing the appearance of blemishes and redness, making it a preferable
choice for individuals with sensitive or easily irritated skin.
Additionally, caffeoyl dipeptide
has shown promising results in enhancing the skin's natural barrier function. A robust skin barrier is
essential in preventing trans-epidermal water loss and shielding the skin against harmful external
factors. By reinforcing the barrier, this dipeptide ensures that the skin remains hydrated and
protected, which is crucial for maintaining overall skin health and vitality.
Furthermore,
caffeoyl dipeptide can promote skin repair and regeneration. It stimulates the production of collagen
and elastin, key proteins that contribute to skin firmness and elasticity. With regular use, users might
notice a reduction in the visibility of fine lines and wrinkles, along with an improvement in skin
texture and suppleness. This regenerative capacity makes caffeoyl dipeptide an attractive ingredient for
anti-aging skincare products.
Finally, caffeoyl dipeptide can also enhance the efficacy of other
active ingredients when used in synergy with them. By preparing the skin to better absorb nutrients and
active compounds, it maximizes the benefits of a comprehensive skincare regimen. This versatility and
enhancement capability mean that it can be included in a wide range of products, from serums to creams,
catering to different consumer needs.
How does caffeoyl dipeptide differ from other dipeptides in
its function and effects on the skin?
Caffeoyl dipeptide is distinct from other dipeptides
primarily due to its incorporation of caffeic acid, a well-known antioxidant and anti-inflammatory
agent. This unique aspect brings about advanced functionalities that are not typically present in other
dipeptides. While dipeptides, in general, are small peptides that can easily penetrate the skin barrier
to deliver active compounds where they are needed most, caffeoyl dipeptide goes beyond by merging these
general benefits with the potent capabilities of caffeic acid.
One primary distinction is its
superior antioxidant performance. While many dipeptides may offer some degree of antioxidant protection,
the caffeic component of caffeoyl dipeptide provides a robust scavenging activity against free radicals,
which are a primary cause of premature skin aging. This results in a significant reduction in oxidative
damage when compared to other peptides that do not integrate strong antioxidant
elements.
Additionally, the anti-inflammatory effects of caffeoyl dipeptide are more pronounced.
While peptides generally contribute to calming the skin and reducing irritation, the presence of caffeic
acid enhances this calming effect, providing a natural means to relieve redness and discomfort. This
makes it highly beneficial for individuals struggling with inflammatory skin conditions like rosacea or
acne.
Another way caffeoyl dipeptide stands apart is through its capacity to promote collagen
synthesis more effectively. Collagen is vital for maintaining skin elasticity and minimizing signs of
aging. While many peptides contribute to stimulating collagen production, the combination of peptide
with caffeic acid in caffeoyl dipeptide takes this functionality to a higher level. It more effectively
activates the skin's repair processes, leading to improved elastic properties and a visible reduction in
fine lines and wrinkles.
Furthermore, caffeoyl dipeptide can enhance cellular energy and
regeneration rates, which is something not typically addressed by other dipeptides. It helps improve the
skin’s metabolic processes, ensuring that cells regenerate more efficiently and recover from damage
quicker. This regeneration creates a more youthful, vibrant complexion by encouraging the skin cells to
operate at optimal levels.
In conclusion, while all dipeptides offer beneficial properties,
caffeoyl dipeptide's integration of caffeic acid provides a multi-faceted approach to skincare. It
offers enhanced antioxidant protection, superior anti-inflammatory effects, and amplified stimulation of
collagen synthesis along with improved cellular regeneration, setting it apart as a powerhouse
ingredient in innovative skincare formulations.
Can people with sensitive skin use products
containing caffeoyl dipeptide?
People with sensitive skin often face challenges when selecting
skincare products that will not cause irritation, redness, or adverse reactions. Given this, the
compatibility of caffeoyl dipeptide with sensitive skin is a topic of relevance and interest. Firstly,
caffeoyl dipeptide is known for its calming anti-inflammatory properties. These properties are vital for
individuals with sensitive skin who require ingredients that can soothe irritation rather than
exacerbate it. Caffeoyl dipeptide helps alleviate redness and reduces inflammatory responses in the
skin, which can be triggered by environmental stressors or allergens. This makes it a favorable
ingredient for those who routinely battle with sensitive skin issues.
Moreover, caffeoyl
dipeptide's small molecular structure allows it to penetrate the skin barrier without causing congestion
or irritation. Its ability to deliver active components effectively while maintaining skin integrity is
a significant advantage for sensitive skin. This non-intrusive penetration is crucial as it ensures that
the beneficial effects of caffeoyl dipeptide are experienced without disturbing the delicate balance of
sensitive skin.
Another point to consider is the risk of allergic reactions. Ingredients with
high allergenic potential can often cause more harm than good, particularly for those with sensitive
skin types. However, caffeoyl dipeptide is generally considered to have a low risk of allergies. This
aspect is supported by the fact that it is derived from naturally occurring compounds, which are less
likely to irritate the skin compared to synthetic or harsh chemicals.
Additionally, caffeoyl
dipeptide enhances the skin’s natural barrier, offering an additional layer of protection. This is
particularly beneficial for sensitive skin, which can often be compromised and more prone to
environmental aggressors that contribute to irritation. By fortifying the barrier, it helps sensitive
skin retain moisture and keep irritants out, leading to stronger and more resilient skin over
time.
Nonetheless, it is always advisable for individuals with sensitive skin to perform a patch
test before fully integrating any new product into their routine. This is a prudent strategy to ensure
the skin’s tolerance and adaptability to caffeoyl dipeptide, even though reports of adverse reactions
are minimal.
Overall, caffeoyl dipeptide represents a promising ingredient for those with
sensitive skin due to its gentle yet effective properties. Its calmative, non-irritating, and protective
characteristics make it an admirable choice for individuals looking to enhance their skincare regimen
without compromising on safety or efficacy.
How does caffeoyl dipeptide enhance collagen
production in the skin?
Collagen, a structural protein critical for skin elasticity and firmness,
diminishes naturally with age, contributing to wrinkles and sagging. Caffeoyl dipeptide plays a
transformative role in enhancing collagen production, providing a potential solution to the challenges
posed by the natural decline of this protein. At the heart of this mechanism is the ability of caffeoyl
dipeptide to stimulate the skin's fibroblasts—cells responsible for producing collagen. This stimulation
is largely attributed to the unique synergistic action of peptides and caffeic acid present in the
compound.
When applied, caffeoyl dipeptide penetrates the skin and directly interacts with these
fibroblasts, encouraging them to upregulate collagen synthesis. This contrasts with many standard
peptides which may only provide surface-level effects or involve more indirect mechanisms of action. The
increased activity of fibroblasts contributes to more collagen fibers being produced, which ultimately
leads to improved skin elasticity and resilience. Enhanced elasticity not only helps in reducing the
appearance of existing wrinkles but also acts as a preventative measure against the formation of new
ones.
The incorporation of caffeic acid within the peptide structure allows caffeoyl dipeptide to
exhibit strong antioxidant activities. Oxidative stress, primarily caused by environmental factors like
UV radiation and pollutants, can inhibit collagen production by damaging fibroblasts and existing
collagen structures. The antioxidant properties of caffeoyl dipeptide protect these cells from oxidative
damage, thus maintaining optimal conditions for collagen synthesis. This protective role helps preserve
collagen levels within the dermis and supports the skin’s structural framework.
Moreover,
caffeoyl dipeptide’s anti-inflammatory properties also contribute significantly to its ability to boost
collagen production. Chronic inflammation can degrade collagen, and by mitigating such inflammation,
caffeoyl dipeptide ensures a conducive environment for collagen synthesis to thrive. By reducing
inflammatory markers, it provides a pathway for cellular environments to repair efficiently and sustain
collagen turnover.
Furthermore, caffeoyl dipeptide promotes enhanced cellular communication. This
improved signaling pathway fortifies skin cells' ability to respond to damage and initiate repair
processes, which are crucial when considering the role of collagen in wound healing and skin integrity.
This holistic involvement in rejuvenating the skin’s infrastructure marks caffeoyl dipeptide as more
than just a collagen booster but as a regenerative catalyst.
In conclusion, caffeoyl dipeptide's
impact on collagen synthesis is comprehensive. By stimulating fibroblasts, protecting against oxidative
stress, mitigating inflammation, and enhancing cellular communication, it ensures that the skin receives
ample support to maintain collagen levels. This robust approach not only revitalizes skin appearance but
also fortifies its biological functions against the visible and unseen effects of aging, delivering both
preventative and corrective benefits to various skin types.
What role does caffeoyl dipeptide
play in skin barrier repair?
The skin barrier, also known as the stratum corneum, acts as the
body's first line of defense against environmental aggressors, pollutants, and pathogens while also
preventing excessive water loss. When this barrier is compromised, it can result in conditions such as
dryness, irritation, and increased susceptibility to infections. Caffeoyl dipeptide's multifaceted
properties make it an exceptional candidate for enhancing and repairing the skin barrier, ensuring the
skin remains healthy and resilient.
One of the primary roles of caffeoyl dipeptide in skin
barrier repair is its ability to reduce inflammation. Inflammation is a common culprit in barrier
dysfunction, often resulting from exposure to irritants, allergens, or environmental factors. The
anti-inflammatory properties of caffeoyl dipeptide help to soothe inflamed skin and promote a return to
normal barrier function. By calming the skin, caffeoyl dipeptide aids in the recovery of the structural
components of the barrier, leading to a smoother and more stable surface.
Caffeoyl dipeptide also
acts as a potent antioxidant, combating oxidative stress caused by free radicals. Free radicals can
damage lipids and proteins crucial to maintaining the integrity of the skin barrier. By neutralizing
these harmful molecules, caffeoyl dipeptide prevents the breakdown of the barrier, aiding in both the
protection and preservation of its structure. This protection ensures that the skin retains its
essential functions, such as moisture retention and defensive capability against environmental
harm.
The reparative capabilities of caffeoyl dipeptide extend to enhancing lipid synthesis
within the skin. Lipids are vital for a healthy skin barrier as they fill in the gaps between skin
cells, ensuring minimal water loss and maximal elasticity. By promoting lipid production, caffeoyl
dipeptide aids in restoring the lipid matrix, ensuring that the skin barrier remains intact and
functional. This aspect is particularly beneficial for individuals with dry or eczema-prone skin, where
lipid content often diminishes.
Moreover, caffeoyl dipeptide improves cellular regeneration and
turnover, crucial for the repair and maintenance of the skin barrier. By promoting new skin cell
production, it helps replace damaged cells with new, robust ones, ensuring a fortified barrier. This
cellular renewal process is essential for the ongoing maintenance and resilience of the skin's outermost
layer.
Lastly, caffeoyl dipeptide enhances the overall hydration of the skin. This is significant
as hydrated skin is less prone to damage and better equipped to perform its barrier function. By
attracting moisture and aiding in its retention, caffeoyl dipeptide supports the skin in maintaining its
suppleness and protective capabilities.
In summary, caffeoyl dipeptide plays a crucial role in
skin barrier repair through its anti-inflammatory, antioxidant, lipid-enhancing, and hydrating effects.
These combined actions help maintain the skin's health, prevent damage, and promote overall resilience.
The comprehensive benefits of caffeoyl dipeptide make it an indispensable ingredient in formulations
aimed at barrier repair and fortification.
Can caffeoyl dipeptide be used in conjunction with
other skincare ingredients for enhanced efficacy?
Caffeoyl dipeptide is a versatile ingredient
that can indeed be used in conjunction with other skincare ingredients to enhance efficacy and provide a
well-rounded approach to skincare. Collaborating multiple skincare actives can often amplify benefits,
address multiple skin concerns simultaneously, and provide a personalized regimen to meet specific
needs.
One key characteristic of caffeoyl dipeptide is its compatibility with other antioxidants
like vitamin C or vitamin E. When combined, these antioxidants can provide a broader spectrum of free
radical neutralization and environmental protection. While caffeoyl dipeptide offers specific
antioxidant benefits through caffeic acid, vitamin C and E work synergistically to reinforce the
protective barrier against oxidative stress, improving the skin’s resistance to aging and
damage.
Combining caffeoyl dipeptide with hyaluronic acid is another effective strategy,
particularly for those with dry or dehydrated skin. While caffeoyl dipeptide contributes regenerative
and protective benefits, hyaluronic acid excels in hydration. The deep moisturization provided by
hyaluronic acid complements the barrier-strengthening effects of caffeoyl dipeptide, resulting in
plumper, more hydrated skin with improved elasticity.
For anti-aging regimens, caffeoyl dipeptide
can be paired with retinoids or peptides such as palmitoyl pentapeptide. Retinoids are celebrated for
their ability to increase cell turnover and stimulate collagen synthesis. When used with caffeoyl
dipeptide, the combined effort amplifies the skin-rejuvenating activities, offering superior collagen
boosting and wrinkle reduction benefits. While retinoids work on accelerating skin renewal, caffeoyl
dipeptide supports the inflammation-calming aspect, reducing potential irritation often caused by
retinoids.
Using caffeoyl dipeptide alongside niacinamide can also provide amplified skin
benefits. Niacinamide is known for its ability to soothe inflammation, improve pore appearance, and even
out skin tone. When combined with caffeoyl dipeptide, the duo provides comprehensive anti-inflammatory
support, making them suitable for sensitive or acne-prone skin types. This combination works to ensure
that skin appears more even-toned while feeling calm and supple.
In addition, caffeoyl
dipeptide's gentle nature allows it to be formulated with exfoliating agents such as alpha-hydroxy acids
(AHAs) like glycolic or lactic acid. The exfoliation provided by AHAs can clear dead skin cells,
enhancing the penetration and effectiveness of caffeoyl dipeptide, thereby improving its access to
deeper skin layers where repair and regeneration occur. This combination facilitates a smoother,
brighter complexion while mitigating the risk of irritation often associated with
exfoliation.
Despite these potential combinations, it is crucial to introduce new combinations
gradually and observe the skin’s response. While caffeoyl dipeptide is generally well-tolerated,
individual sensitivities can vary, and layering too many actives simultaneously might overwhelm the
skin.
In conclusion, caffeoyl dipeptide can be effectively combined with various skincare
ingredients to address multiple concerns and enhance overall skincare results. Its compatibility and
synergistic qualities make it a valuable adaptable component in comprehensive skincare routines,
offering enhanced protection, rejuvenation, and hydration benefits.