Synonym |
NH2-Met-His-Asp-Gly-Tyr-Arg-COOH |
Species |
Human |
Protein Accession |
P15559 |
Purity |
≥ 95% |
Endotoxin Level |
< 1.0 EU per 1 μg of the protein |
Biological Activity |
Stimulates collagen and hyaluronic acid production in fibroblasts |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
842.9 Da |
Formulation |
Lyophilized powder |
Reconstitution |
Reconstitute in water to a concentration of 0.1-1.0 mg/ml |
Storage & Stability |
Store at -20°C upon arrival. Stable for up to 12 months at -20°C. |
FAQ
What is Nicotinoyl Hexapeptide and how does it work in skincare products?
Nicotinoyl Hexapeptide is
a specialized peptide derivative used in skincare products due to its potential benefits for skin
rejuvenation and enhancement. This compound is essentially a hexapeptide that has been modified with a
nicotinoyl group. Peptides are short chains of amino acids, which are the building blocks of proteins.
In the skin, peptides play crucial roles in building and maintaining proteins like collagen and elastin.
These proteins are key to keeping the skin firm, supple, and youthful. As the nicotinoyl group in
Nicotinoyl Hexapeptide suggests, it is associated with niacinamide or vitamin B3, which is renowned for
various skin benefits, including improving the skin barrier, evening out skin tone, and enhancing
hydration.
When Nicotinoyl Hexapeptide is applied to the skin, it is absorbed and can penetrate
the epidermis, the outermost layer of the skin. Once there, it works at a molecular level to interact
with skin cells, encouraging them to behave more like youthful, healthy cells. The nicotinoyl portion
can contribute to cellular communication, facilitating better cellular functions and a restructured skin
matrix. Additionally, it has been suggested to support the synthesis of collagen and elastin. This is
crucial because as we age, the natural production of these proteins slows down, leading to the
development of fine lines, wrinkles, and loss of skin firmness.
Moreover, Nicotinoyl Hexapeptide
may have antioxidative properties due to the nicotinoyl component. Antioxidants play a key role in
protecting the skin from oxidative stress caused by environmental factors such as pollution, UV rays,
and free radicals. By neutralizing these free radicals, the peptide helps in preventing premature aging
and the formation of new wrinkles and fine lines. This aspect can be particularly beneficial in skincare
formulations designed for anti-aging and skin repair.
Furthermore, regular use of products
containing Nicotinoyl Hexapeptide may lead to improvements in skin texture and clarity. The peptide can
promote a more even skin tone by reducing redness and brightening dull, fatigued skin. Its effects on
the skin's barrier function can also help enhance moisture retention and protect against external
irritants, making the skin more resilient and hydrated. With ongoing usage, users can experience a more
rejuvenated, youthful complexion with less-visible signs of aging.
In terms of safety, Nicotinoyl
Hexapeptide is generally considered safe for most skin types, but like any skincare ingredient, a patch
test is recommended before extensive use. Some users might experience mild irritation if they have
sensitive skin; hence starting with a lower concentration and gradually increasing it is advisable.
Overall, Nicotinoyl Hexapeptide’s multi-functional approach in skincare makes it a popular choice for
those seeking comprehensive anti-aging solutions without invasive procedures.
How does Nicotinoyl
Hexapeptide contribute to anti-aging?
Nicotinoyl Hexapeptide is lauded in the skincare industry
for its multifaceted anti-aging benefits, which are primarily attributed to its unique composition and
mechanism of action. At the core of these benefits is its peptide nature, specifically its identity as a
hexapeptide, combined with a nicotinoyl group. Peptides are integral to skincare because they mimic
protein-building blocks that signal the skin to trigger the production of collagen and elastin—two
proteins critical for maintaining skin's structural integrity. As we age, the natural production of
these proteins diminishes, leading to the sagging skin, fine lines, and wrinkles that are often
associated with aging.
By incorporating Nicotinoyl Hexapeptide into a regular skincare routine,
individuals can effectively boost the synthesis of collagen and elastin. This increase in protein
production aids in tightening and firming the skin, thus reducing the appearance of wrinkles and fine
lines. The skin regains its youthful elasticity and firmness, offering the appearance of a more toned
and lifted face. In essence, it helps to reverse and mitigate signs of aging that occur naturally over
time.
In addition to boosting collagen, the nicotinoyl component introduces the benefits of
niacinamide, known for its antioxidative properties. This ingredient protects the skin from oxidative
damage caused by free radicals, which are unstable molecules generated by environmental aggressors such
as UV radiation, pollution, and stress. Oxidative stress is a principal culprit in premature skin aging,
causing exacerbated formation of lines, loss of elasticity, and damage to the overall skin texture. By
neutralizing these free radicals, Nicotinoyl Hexapeptide minimizes new wrinkle formation and protects
the skin's youthful appearance.
Moreover, Nicotinoyl Hexapeptide enhances the skin's barrier
function. A well-functioning skin barrier is crucial for retaining moisture and defending against
environmental stresses and pathogens. A strong barrier means that the skin can better retain hydration,
reducing dryness and flakiness, which are common signs of aged and tired skin. Consistent usage of
Nicotinoyl Hexapeptide allows the skin to stay hydrated over time, which in itself smooths out the
appearance of fine lines and enhances skin texture.
Another noteworthy attribute of Nicotinoyl
Hexapeptide in the realm of anti-aging is its ability to even out skin tone and improve skin clarity.
With age, uneven pigmentation and age spots become more pronounced. The brightening effect brought by
the nicotinoyl group can mitigate hyperpigmentation and promote a radiant, even complexion. Nicotinoyl
Hexapeptide works synergistically to correct discoloration and support an even tone, further
contributing to a youthful skin appearance.
Furthermore, the peptide's role in cellular
communication cannot be overstated. It sends signals to cells, encouraging them to behave in a younger
manner, effectively revitalizing aged skin. This signaling results in improved cell turnover rates,
mimicking the naturally faster cell regeneration cycle found in younger skin. This results in a
smoother, more youthful skin surface.
Overall, Nicotinoyl Hexapeptide provides a comprehensive
anti-aging solution, addressing multiple aspects of the aging process. By simultaneously engaging in
collagen promotion, antioxidative protection, enhanced moisture retention, evening out skin tone, and
promoting healthy cell communication, Nicotinoyl Hexapeptide becomes a highly effective ingredient in
anti-aging skincare formulations.
Is Nicotinoyl Hexapeptide suitable for all skin
types?
Nicotinoyl Hexapeptide is generally considered to be a versatile ingredient suitable for a
wide range of skin types due to its gentle yet effective profile. However, it is important to understand
how it interacts with different skin types and any considerations that might be relevant for specific
concerns.
For normal skin types, Nicotinoyl Hexapeptide can be an excellent addition to a
skincare routine aimed at preserving youthful skin properties. It aids in maintaining skin firmness and
elasticity, helping to stave off early signs of aging like fine lines and minor wrinkles. Normal skin
generally handles peptides well, and the antimicrobial properties associated with the nicotinoyl
component can keep the skin clear and healthy.
Oily skin often struggles with overproduction of
sebum, leading to clogged pores and acne breakouts. Nicotinoyl Hexapeptide can be beneficial here
because it can help balance oil production while ensuring the skin remains hydrated. The hydrating
effect without being overly greasy makes it an ideal choice for those with oily skin who are prone to
dehydration and want to avoid oil-heavy moisturizers.
Dry skin types will appreciate the
barrier-strengthening properties of Nicotinoyl Hexapeptide. Dryness often signifies a weakened barrier,
leading to moisture loss. By improving barrier function, this peptide helps the skin retain moisture
more effectively, preventing the tightness and flakiness associated with dehydration. Moreover, the
moisture-boosting property enhances the suppleness and smoothness of dry skin, making it appear
well-nourished and rejuvenated.
For sensitive skin, there's often a concern about the potential
for irritation when introducing new products. Generally, Nicotinoyl Hexapeptide is non-irritating and
gentle, but individual reactions can vary. Hence, patch testing is advised before full application. This
test involves applying a small amount of the product on a discreet part of the skin and waiting for 24
hours to see if any adverse reaction occurs. In many cases, users with sensitive skin find this peptide
to be effective without causing irritation, redness, or discomfort, mainly because it does not involve
harsh chemicals or physical exfoliants.
Combination skin types, which experience both oily and
dry areas, particularly benefit from the balancing properties of Nicotinoyl Hexapeptide. It provides
hydration to dry areas and regulates oil production in oily zones, striving to maintain an even
complexion throughout. It suits the dynamic needs of combination skin without overwhelming any
particular area.
Additionally, given the potential for promoting collagen and elastin and its
antioxidative properties, Nicotinoyl Hexapeptide is beneficial for mature skin. It's often used in
formulations targeting aging since it can help firm skin, reduce the appearance of wrinkles, and improve
elasticity and resilience.
It’s important to note that while Nicotinoyl Hexapeptide is versatile,
individual experiences can vary, and other ingredients within specific formulations can also affect how
someone’s skin might react. Anyone with existing skin conditions like eczema, rosacea, or severe acne
should consult with a dermatologist to ensure compatibility with their specific skin needs. Despite its
general suitability, starting with a lower concentration and adjusting as necessary based on skin's
response is always a prudent strategy with new skincare ingredients. Overall, for most users across
various skin types, Nicotinoyl Hexapeptide represents an exciting opportunity to enhance skin care
routines in a gentle, effective manner.