Taiy Chemical
Nicotinoyl Hexapeptide
Synonym NH2-Met-His-Asp-Gly-Tyr-Arg-COOH
Species Human
Protein Accession P15559
Purity ≥ 95%
Endotoxin Level < 1.0 EU per 1 μg of the protein
Biological Activity Stimulates collagen and hyaluronic acid production in fibroblasts
Expression System E. coli
Fusion Tag None
Predicted Molecular Mass 842.9 Da
Formulation Lyophilized powder
Reconstitution Reconstitute in water to a concentration of 0.1-1.0 mg/ml
Storage & Stability Store at -20°C upon arrival. Stable for up to 12 months at -20°C.
FAQ
What is Nicotinoyl Hexapeptide and how does it work in skincare products?
Nicotinoyl Hexapeptide is a specialized peptide derivative used in skincare products due to its potential benefits for skin rejuvenation and enhancement. This compound is essentially a hexapeptide that has been modified with a nicotinoyl group. Peptides are short chains of amino acids, which are the building blocks of proteins. In the skin, peptides play crucial roles in building and maintaining proteins like collagen and elastin. These proteins are key to keeping the skin firm, supple, and youthful. As the nicotinoyl group in Nicotinoyl Hexapeptide suggests, it is associated with niacinamide or vitamin B3, which is renowned for various skin benefits, including improving the skin barrier, evening out skin tone, and enhancing hydration.

When Nicotinoyl Hexapeptide is applied to the skin, it is absorbed and can penetrate the epidermis, the outermost layer of the skin. Once there, it works at a molecular level to interact with skin cells, encouraging them to behave more like youthful, healthy cells. The nicotinoyl portion can contribute to cellular communication, facilitating better cellular functions and a restructured skin matrix. Additionally, it has been suggested to support the synthesis of collagen and elastin. This is crucial because as we age, the natural production of these proteins slows down, leading to the development of fine lines, wrinkles, and loss of skin firmness.

Moreover, Nicotinoyl Hexapeptide may have antioxidative properties due to the nicotinoyl component. Antioxidants play a key role in protecting the skin from oxidative stress caused by environmental factors such as pollution, UV rays, and free radicals. By neutralizing these free radicals, the peptide helps in preventing premature aging and the formation of new wrinkles and fine lines. This aspect can be particularly beneficial in skincare formulations designed for anti-aging and skin repair.

Furthermore, regular use of products containing Nicotinoyl Hexapeptide may lead to improvements in skin texture and clarity. The peptide can promote a more even skin tone by reducing redness and brightening dull, fatigued skin. Its effects on the skin's barrier function can also help enhance moisture retention and protect against external irritants, making the skin more resilient and hydrated. With ongoing usage, users can experience a more rejuvenated, youthful complexion with less-visible signs of aging.

In terms of safety, Nicotinoyl Hexapeptide is generally considered safe for most skin types, but like any skincare ingredient, a patch test is recommended before extensive use. Some users might experience mild irritation if they have sensitive skin; hence starting with a lower concentration and gradually increasing it is advisable. Overall, Nicotinoyl Hexapeptide’s multi-functional approach in skincare makes it a popular choice for those seeking comprehensive anti-aging solutions without invasive procedures.

How does Nicotinoyl Hexapeptide contribute to anti-aging?

Nicotinoyl Hexapeptide is lauded in the skincare industry for its multifaceted anti-aging benefits, which are primarily attributed to its unique composition and mechanism of action. At the core of these benefits is its peptide nature, specifically its identity as a hexapeptide, combined with a nicotinoyl group. Peptides are integral to skincare because they mimic protein-building blocks that signal the skin to trigger the production of collagen and elastin—two proteins critical for maintaining skin's structural integrity. As we age, the natural production of these proteins diminishes, leading to the sagging skin, fine lines, and wrinkles that are often associated with aging.

By incorporating Nicotinoyl Hexapeptide into a regular skincare routine, individuals can effectively boost the synthesis of collagen and elastin. This increase in protein production aids in tightening and firming the skin, thus reducing the appearance of wrinkles and fine lines. The skin regains its youthful elasticity and firmness, offering the appearance of a more toned and lifted face. In essence, it helps to reverse and mitigate signs of aging that occur naturally over time.

In addition to boosting collagen, the nicotinoyl component introduces the benefits of niacinamide, known for its antioxidative properties. This ingredient protects the skin from oxidative damage caused by free radicals, which are unstable molecules generated by environmental aggressors such as UV radiation, pollution, and stress. Oxidative stress is a principal culprit in premature skin aging, causing exacerbated formation of lines, loss of elasticity, and damage to the overall skin texture. By neutralizing these free radicals, Nicotinoyl Hexapeptide minimizes new wrinkle formation and protects the skin's youthful appearance.

Moreover, Nicotinoyl Hexapeptide enhances the skin's barrier function. A well-functioning skin barrier is crucial for retaining moisture and defending against environmental stresses and pathogens. A strong barrier means that the skin can better retain hydration, reducing dryness and flakiness, which are common signs of aged and tired skin. Consistent usage of Nicotinoyl Hexapeptide allows the skin to stay hydrated over time, which in itself smooths out the appearance of fine lines and enhances skin texture.

Another noteworthy attribute of Nicotinoyl Hexapeptide in the realm of anti-aging is its ability to even out skin tone and improve skin clarity. With age, uneven pigmentation and age spots become more pronounced. The brightening effect brought by the nicotinoyl group can mitigate hyperpigmentation and promote a radiant, even complexion. Nicotinoyl Hexapeptide works synergistically to correct discoloration and support an even tone, further contributing to a youthful skin appearance.

Furthermore, the peptide's role in cellular communication cannot be overstated. It sends signals to cells, encouraging them to behave in a younger manner, effectively revitalizing aged skin. This signaling results in improved cell turnover rates, mimicking the naturally faster cell regeneration cycle found in younger skin. This results in a smoother, more youthful skin surface.

Overall, Nicotinoyl Hexapeptide provides a comprehensive anti-aging solution, addressing multiple aspects of the aging process. By simultaneously engaging in collagen promotion, antioxidative protection, enhanced moisture retention, evening out skin tone, and promoting healthy cell communication, Nicotinoyl Hexapeptide becomes a highly effective ingredient in anti-aging skincare formulations.

Is Nicotinoyl Hexapeptide suitable for all skin types?

Nicotinoyl Hexapeptide is generally considered to be a versatile ingredient suitable for a wide range of skin types due to its gentle yet effective profile. However, it is important to understand how it interacts with different skin types and any considerations that might be relevant for specific concerns.

For normal skin types, Nicotinoyl Hexapeptide can be an excellent addition to a skincare routine aimed at preserving youthful skin properties. It aids in maintaining skin firmness and elasticity, helping to stave off early signs of aging like fine lines and minor wrinkles. Normal skin generally handles peptides well, and the antimicrobial properties associated with the nicotinoyl component can keep the skin clear and healthy.

Oily skin often struggles with overproduction of sebum, leading to clogged pores and acne breakouts. Nicotinoyl Hexapeptide can be beneficial here because it can help balance oil production while ensuring the skin remains hydrated. The hydrating effect without being overly greasy makes it an ideal choice for those with oily skin who are prone to dehydration and want to avoid oil-heavy moisturizers.

Dry skin types will appreciate the barrier-strengthening properties of Nicotinoyl Hexapeptide. Dryness often signifies a weakened barrier, leading to moisture loss. By improving barrier function, this peptide helps the skin retain moisture more effectively, preventing the tightness and flakiness associated with dehydration. Moreover, the moisture-boosting property enhances the suppleness and smoothness of dry skin, making it appear well-nourished and rejuvenated.

For sensitive skin, there's often a concern about the potential for irritation when introducing new products. Generally, Nicotinoyl Hexapeptide is non-irritating and gentle, but individual reactions can vary. Hence, patch testing is advised before full application. This test involves applying a small amount of the product on a discreet part of the skin and waiting for 24 hours to see if any adverse reaction occurs. In many cases, users with sensitive skin find this peptide to be effective without causing irritation, redness, or discomfort, mainly because it does not involve harsh chemicals or physical exfoliants.

Combination skin types, which experience both oily and dry areas, particularly benefit from the balancing properties of Nicotinoyl Hexapeptide. It provides hydration to dry areas and regulates oil production in oily zones, striving to maintain an even complexion throughout. It suits the dynamic needs of combination skin without overwhelming any particular area.

Additionally, given the potential for promoting collagen and elastin and its antioxidative properties, Nicotinoyl Hexapeptide is beneficial for mature skin. It's often used in formulations targeting aging since it can help firm skin, reduce the appearance of wrinkles, and improve elasticity and resilience.

It’s important to note that while Nicotinoyl Hexapeptide is versatile, individual experiences can vary, and other ingredients within specific formulations can also affect how someone’s skin might react. Anyone with existing skin conditions like eczema, rosacea, or severe acne should consult with a dermatologist to ensure compatibility with their specific skin needs. Despite its general suitability, starting with a lower concentration and adjusting as necessary based on skin's response is always a prudent strategy with new skincare ingredients. Overall, for most users across various skin types, Nicotinoyl Hexapeptide represents an exciting opportunity to enhance skin care routines in a gentle, effective manner.
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