Synonym |
Nicotinamide peptide, NOpt |
Species |
Human |
Protein Accession |
P12345 |
Purity |
≥ 98% |
Endotoxin Level |
< 1.0 EU per µg |
Biological Activity |
Potent stimulator of nicotinamide adenine dinucleotide (NAD) biosynthesis |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
1.5 kDa |
Formulation |
Lyophilized |
Reconstitution |
Reconstitute in sterile water to a concentration not less than 100 µg/ml |
Storage & Stability |
Store at -20°C. For long-term storage, store at -80°C. Stable for 12 months after receipt |
FAQ
What is Nicotinoyl Octapeptide, and how does it function in skincare products?
Nicotinoyl
Octapeptide is a cutting-edge peptide innovation in the skincare industry known for its remarkable
ability to enhance the overall appearance of the skin. This advanced compound combines two powerful
components: nicotinic acid, commonly known as niacinamide or vitamin B3, and octapeptides, which are
chains of amino acids. Niacinamide is renowned for its multiple skin benefits, including improving the
skin's barrier function, increasing elasticity, mitigating inflammatory responses, and evening out skin
tone. On the other hand, peptides are celebrated for their role in stimulating collagen production,
leading to firmer and more youthful skin.
When these two elements come together in Nicotinoyl
Octapeptide, they create a powerhouse ingredient that addresses numerous skin concerns simultaneously.
The peptide chain serves as a messenger, sending signals to skin cells to increase collagen synthesis
and repair damaged cells. Meanwhile, the niacinamide component enhances these effects by reducing
inflammation, brightening the complexion, and ensuring the skin's ceramide production remains optimal.
By improving the skin's moisture retention and defensive barrier, this compound aids in reducing the
appearance of fine lines and wrinkles, thereby promoting a smoother, plumper skin texture.
The
molecular configuration of Nicotinoyl Octapeptide ensures efficient penetration into the deeper layers
of the skin, making its effects more potent and long-lasting. This deeper delivery system not only
maximizes the active benefits of the compound but also helps in enhancing the delivery of other
beneficial agents in skincare formulations. Users of products containing Nicotinoyl Octapeptide often
report noticeable improvements in the suppleness and radiance of their skin, affirming its role as a
formidable component in modern anti-aging and corrective skincare solutions.
What are the
benefits of using skincare products that contain Nicotinoyl Octapeptide?
The benefits of using
skincare products containing Nicotinoyl Octapeptide are extensive and multifaceted, making it a
sought-after ingredient for individuals looking to address a variety of skin concerns. One of the
foremost advantages is its ability to significantly enhance skin firmness and elasticity. By stimulating
collagen and elastin production, Nicotinoyl Octapeptide helps in tightening the skin and reducing
sagging, which is beneficial for those experiencing loss of skin structure due to aging or environmental
damage.
Another key benefit is its capacity to improve the skin's moisture barrier, which is
crucial for maintaining hydrated and healthy skin. Nicotinoyl Octapeptide boosts ceramide production,
enhancing the skin's natural protective layer, which in turn helps in retaining moisture and protecting
against environmental aggressors like UV radiation and pollution. This moisture retention is
particularly beneficial for individuals with dry or compromised skin, as it alleviates dryness and helps
in maintaining a plump, dewy complexion.
Moreover, Nicotinoyl Octapeptide is known for its
anti-inflammatory properties, which can be highly beneficial for those dealing with inflammatory skin
issues such as acne, rosacea, or redness. By calming irritated skin and reducing redness, it helps in
achieving a more even and clear complexion. Additionally, its brightening effects are another
significant advantage. By inhibiting the transfer of melanin, it aids in diminishing dark spots and
hyperpigmentation, leading to a more uniform skin tone.
Furthermore, the antioxidant properties
of Nicotinoyl Octapeptide play a crucial role in neutralizing free radicals, which can prevent premature
skin aging and cellular damage. The combination of these benefits makes it an exceptional ingredient in
anti-aging skincare, offering comprehensive skin rejuvenation. Regular use of products containing
Nicotinoyl Octapeptide can result in a visible transformation in skin texture, tone, and resilience,
making it a superior choice for individuals aiming to enhance their skincare regimen with a versatile
and potent ingredient.
Is Nicotinoyl Octapeptide suitable for all skin types, including sensitive
skin?
Nicotinoyl Octapeptide is indeed an ingredient that is generally considered suitable for
all skin types, including sensitive skin, due to its gentle yet effective nature. The peptides in
Nicotinoyl Octapeptide are known for being well-tolerated by most skin types because they work by
mimicking natural processes in the body to boost skin health. This makes them less likely to cause
irritation compared to some other potent anti-aging ingredients.
One of the reasons Nicotinoyl
Octapeptide is suitable for sensitive skin is its anti-inflammatory properties, which help soothe
irritation and reduce redness. For individuals with sensitive skin, inflammation and irritation are
common concerns, and using products that can help mitigate these issues without causing additional
sensitivity is highly beneficial. The inclusion of niacinamide in Nicotinoyl Octapeptide formulations
further enhances its suitability for sensitive skin. Niacinamide is known for its calming properties,
which help to soothe the skin and reduce the incidence of flare-ups, making it an excellent choice for
those with conditions like rosacea or eczema.
Furthermore, Nicotinoyl Octapeptide strengthens the
skin barrier function, assisting sensitive skin by improving its resilience against external aggressors.
This enhancement of the skin's defense mechanism is crucial for preventing transepidermal water loss,
which often exacerbates sensitivity issues. By fortifying the skin’s barrier, it also aids in protecting
the skin from environmental pollutants that often trigger irritations in sensitive
individuals.
However, while Nicotinoyl Octapeptide is suitable for sensitive skin, it’s always
advised for individuals to conduct a patch test when trying out new skincare products, especially if
they have a history of allergic reactions or extremely reactive skin. This precaution ensures that the
product does not cause any unforeseen adverse reactions. Overall, Nicotinoyl Octapeptide's blend of
strengthening, calming, and rejuvenating properties makes it a versatile choice for those with various
skin types, offering benefits without compromising gentleness.
How does Nicotinoyl Octapeptide
compare to other anti-aging ingredients like retinol?
Nicotinoyl Octapeptide and retinol are both
renowned in the skincare industry for their anti-aging properties, but they operate through different
mechanisms and can have varying effects on the skin. Retinol, a derivative of vitamin A, is known for
its ability to accelerate cell turnover, stimulate collagen production, and diminish the appearance of
fine lines, wrinkles, and hyperpigmentation. It is celebrated for its potency and efficacy but can
sometimes cause irritation, redness, and peeling, especially in individuals with sensitive skin or those
new to retinoids.
In contrast, Nicotinoyl Octapeptide offers a gentler approach to anti-aging. It
combines peptides and niacinamide to enhance the skin's firmness, boost collagen production, and improve
skin tone. Unlike retinol, Nicotinoyl Octapeptide does not typically cause irritation or peeling, making
it a suitable option for those with sensitive skin or individuals who experience adverse reactions to
retinol. While retinol works by increasing the skin cell turnover rate, which can initially lead to
dryness and flakiness as the skin adjusts, Nicotinoyl Octapeptide works by enhancing hydration and
soothing the skin, reducing the likelihood of such side effects.
Another distinction is the
additional benefits offered by Nicotinoyl Octapeptide. The inclusion of niacinamide delivers benefits
such as improved skin barrier function, increased ceramide production, and reduced inflammation, which
can help alleviate conditions like acne and rosacea. Retinol, however, primarily focuses on reducing
signs of aging and may not offer these additional benefits. Moreover, retinol can make the skin more
sensitive to sunlight, necessitating diligent use of sunscreen. Nicotinoyl Octapeptide, on the other
hand, does not increase photosensitivity, providing more convenience in daily skincare routines,
particularly for those with active lifestyles.
Ultimately, the choice between Nicotinoyl
Octapeptide and retinol may come down to individual skin needs and tolerance levels. Some users may find
that incorporating both into their skincare regimen provides comprehensive anti-aging benefits, while
others might opt for one based on their skin's specific requirements or sensitivities. Overall, while
both ingredients are effective, Nicotinoyl Octapeptide offers a gentler alternative with broader
skincare benefits beyond anti-aging alone.
What results can one expect from regular use of
skincare products with Nicotinoyl Octapeptide?
Regular use of skincare products containing
Nicotinoyl Octapeptide can result in a series of visible and beneficial changes to the skin over time.
One of the most notable results is an improvement in skin firmness and elasticity. As the peptide
component works to stimulate collagen production, users often observe their skin becoming noticeably
firmer and more toned, reducing the appearance of sagging and increasing the overall youthful look of
the skin. This is particularly beneficial for those concerned with loss of skin structure due to aging
or environmental factors.
Over time, users may also notice a more hydrated and supple complexion.
Nicotinoyl Octapeptide helps to enhance the moisture barrier of the skin, preventing transepidermal
water loss and retaining skin hydration. Improved moisture retention not only contributes to a healthier
skin appearance but also helps in alleviating dryness and associated skin roughness, leading to a
smoother and softer skin texture. This increase in hydration can make the skin appear more plump and
dewy, a hallmark of youthful skin.
Additionally, regular use can contribute to a reduction in the
appearance of fine lines and wrinkles. While it may not work as aggressively as retinol in this aspect,
its gentle approach ensures a gradual smoothing of the skin’s surface, reducing the depth and visibility
of fine lines without causing irritation. Its calming properties also reduce inflammation and redness,
leading to a more even and luminous complexion.
Furthermore, Nicotinoyl Octapeptide's antioxidant
properties help protect the skin from environmental stressors, such as pollution and UV rays, that can
accelerate aging. This protection helps maintain the skin’s overall vitality and can contribute to a
brighter and more radiant complexion. Its role in melanin regulation aids in evening out pigmentation,
diminishing dark spots, and providing a more uniform skin tone over time.
It's important to note
that individual results can vary and the full benefits are usually more evident after consistent use
over a period of weeks to months. Incorporating Nicotinoyl Octapeptide into a broader skincare routine
that includes sun protection and hydration can maximize its effectiveness and lead to more comprehensive
skin improvements.