Synonym |
Nicotinamide Adenine Dinucleotide Peptide |
Species |
Human |
Protein Accession |
P12345 |
Purity |
≥ 95% |
Endotoxin Level |
< 1.0 EU per µg |
Biological Activity |
The biological activity of Nicotinoyl Pentapeptide is determined by its ability to promote cell
growth. |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
5 kDa |
Formulation |
Lyophilized powder |
Reconstitution |
Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration
of 0.1-1.0 mg/ml |
Storage & Stability |
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12
months. |
FAQ
What is Nicotinoyl Pentapeptide, and how does it benefit the skin?
Nicotinoyl Pentapeptide is a
specialized compound that combines peptides with a nicotinoyl group. Peptides are short chains of amino
acids, which are the building blocks of proteins. In skincare, peptides are highly valued for their
ability to communicate with cells. This communication can lead to various benefits, such as boosting
collagen production, improving skin elasticity, and enhancing skin barrier function. The nicotinoyl
component, derived from niacin (Vitamin B3), is known for its anti-inflammatory and skin-brightening
properties. Together, this combination creates a potent ingredient that not only supports skin repair
and rejuvenation but also offers protective benefits.
The primary advantage of Nicotinoyl
Pentapeptide is its dual action on the skin. The peptide element encourages the synthesis of collagen
and elastin, two crucial proteins for maintaining skin firmness and elasticity. As we age, the
production of these proteins naturally declines, leading to sagging skin and the formation of fine lines
and wrinkles. By stimulating collagen production, Nicotinoyl Pentapeptide can help keep the skin looking
youthful and reduce the visible signs of aging. Additionally, this peptide enhances skin barrier
function, aiding in moisture retention and protecting the skin against environmental damage.
The
nicotinoyl part of the compound further amplifies these benefits by providing soothing and
anti-inflammatory effects, making it especially beneficial for sensitive or irritated skin. It supports
a more even skin tone by inhibiting melanin transfer to the surface, thus reducing hyperpigmentation and
dark spots. Moreover, nicotinoyl has been shown to improve skin texture and reduce pore visibility,
giving the skin a smoother and more refined appearance. Overall, Nicotinoyl Pentapeptide works on
multiple levels to enhance skin health, making it an excellent choice for those looking to maintain or
restore a vibrant, youthful complexion.
How does Nicotinoyl Pentapeptide compare to other popular
skincare ingredients?
Nicotinoyl Pentapeptide stands out in the skincare world due to its
multifunctional properties, offering a combination that many other skincare ingredients do not. While
there are various effective ingredients available, such as retinol, hyaluronic acid, and vitamin C, each
has its particular strengths and potential drawbacks. For example, retinol is widely acclaimed for its
anti-aging benefits, primarily because it increases cell turnover and stimulates collagen production.
However, retinol can often cause irritation, dryness, and increased sensitivity to the sun, which can be
problematic for those with sensitive skin.
On the other hand, hyaluronic acid is famed for its
hydrating properties, capable of holding up to 1000 times its weight in water. This makes it a fantastic
moisturizer and plumps the skin effectively, but it doesn't stimulate collagen or repair skin damage at
the deeper levels like peptides can. Vitamin C, another skincare favorite, works excellently as an
antioxidant and brightening agent, helping to protect against free radical damage and improve skin tone.
Still, it can be unstable in formulations and may cause irritation in some users.
Nicotinoyl
Pentapeptide, due to its peptide and nicotinoyl components, can provide a more comprehensive approach to
skincare. It not only helps to stimulate the production of collagen and elastin like retinol but does so
with less irritation. The nicotinoyl aspect addresses some of the deficiencies seen in other popular
ingredients by reducing inflammation and promoting an even skin tone without the sensitivity issues
often associated with retinol or vitamin C. Moreover, its ability to enhance skin barrier function
offers the hydration benefit similar to hyaluronic acid, preventing moisture loss and ensuring a
plumped, youthful appearance.
Thus, Nicotinoyl Pentapeptide can be considered a versatile
ingredient that tackles various skin concerns simultaneously. Its capability to address aging,
pigmentation, hydration, and sensitivity sets it apart as a more holistic choice for those seeking a
comprehensive solution in their skincare regimen. It integrates the strengths of multiple ingredients
while minimizing the potential drawbacks, making it an increasingly popular choice for both formulators
and consumers aiming for multifunctional skincare solutions.
Can Nicotinoyl Pentapeptide be used
on all skin types, and are there any side effects?
Nicotinoyl Pentapeptide is generally
considered suitable for all skin types, including sensitive and mature skin, due to its gentle and
multifaceted properties. What distinguishes this compound is its capacity to provide significant
skincare benefits without the harsh effects that some other active ingredients might introduce.
Peptides, by their very nature, are relatively gentle and well-tolerated by most skin types. They work
by sending signals to skin cells to prompt various activities, such as collagen synthesis, without
disrupting the skin's natural processes.
The nicotinoyl aspect of Nicotinoyl Pentapeptide adds an
anti-inflammatory layer to this gentle action, making the ingredient even more suitable for sensitive
skin. This combination can help soothe irritation and reduce redness, a common concern for people with
sensitive skin types. The anti-inflammatory properties also mean that the risk of side effects such as
dryness, severe redness, or peeling—often associated with other powerful skincare ingredients like
retinol or glycolic acid—is significantly lower.
Moreover, this compound is also beneficial for
mature skin. As skin ages, it typically becomes drier and more prone to irritation and thinning. The
peptide content encourages firmer, more elastic skin by boosting collagen and elastin production,
addressing common age-related concerns. The nicotinoyl's ability to improve skin texture and brightness
also contributes to a reduction in the appearance of age spots and uneven skin tone.
However, as
with any skincare product, there is a possibility of individual reactions, although these are rare. For
those with extremely sensitive skin or conditions like eczema or rosacea, it is always advisable to
conduct a patch test before full application. Applying a small amount of product on a discrete area and
observing it for 24 hours can help ensure there are no adverse reactions. In case of any discomfort or
adverse changes, consulting a dermatologist is recommended.
Overall, Nicotinoyl Pentapeptide's
formulation makes it adaptable and beneficial for a broad spectrum of skin types, offering an effective
solution with minimal risk of side effects. Thus, it can effectively integrate into skincare routines
for those looking to enhance their skin's overall health and appearance, irrespective of their skin
type.
How should Nicotinoyl Pentapeptide be incorporated into a skincare
routine?
Integrating Nicotinoyl Pentapeptide into a skincare routine can enhance your skin’s
health and appearance due to the compound’s unique, multifaceted benefits. The key to effective skincare
is a consistent and thoughtfully designed routine that addresses your specific skin concerns while
complementing each step of your regimen.
To start, Nicotinoyl Pentapeptide products can be used
both morning and evening, depending on their formulation and your skincare goals. If you're aiming for
anti-aging benefits, consider using a serum or moisturizer containing this peptide to apply after
cleansing and toning. This ensures optimal absorption of the peptide, allowing it to penetrate
effectively where it's needed most. In the morning, this can be followed with a broad-spectrum sunscreen
since protecting the skin from UV exposure is crucial for preventing further damage and supporting the
peptide’s efficacy.
At night, Nicotinoyl Pentapeptide can be an excellent addition to your
restorative skincare routine, as it can work alongside the skin's natural repair processes. After
cleansing, apply the peptide product before heavier serums and night creams. It's important to note that
while this ingredient is generally well-tolerated, begin with once-daily application if you're also
using other active ingredients, such as retinoids or acids, to prevent any potential irritation,
ensuring your skin builds tolerance.
Furthermore, this ingredient can be particularly effective
in targeted treatments, like eye creams, due to its ability to address fine lines and pigmentation. By
using it around the delicate eye area, you can tackle specific concerns like crow's feet and dark
circles. For those considering more comprehensive care, incorporating complementary products like
antioxidants or hyaluronic acid can optimize the peptide's benefits, promoting a comprehensive approach
to skin health. This combination can enhance hydration, protect against environmental stressors, and
improve overall skin elasticity and tone.
Overall, consistency is key to realizing the full
potential of Nicotinoyl Pentapeptide in your routine. While it's versatile enough for various product
types—from serums and creams to masks and targeted treatments—selecting a formulation that aligns with
your specific needs is vital for achieving the desired results. Through regular use, along with
supportive skincare practices like sun protection and hydration, you will likely notice improved skin
texture, tone, and youthfulness over time.
Are there scientific studies supporting the efficacy
of Nicotinoyl Pentapeptide?
The science behind Nicotinoyl Pentapeptide supports its efficacy in
improving various skin conditions, given the well-documented benefits of both peptides and nicotinoyl
components individually. Peptides are renowned for their ability to stimulate skin cells by acting as a
communication bridge, initiating processes like collagen and elastin production. These proteins are
critical for maintaining skin structure and elasticity, with numerous studies highlighting peptides'
effectiveness in reducing fine lines, wrinkles, and sagging.
Peptides, by promoting key
structural proteins, have been the subject of multiple dermatological studies. They consistently show
promise in anti-aging treatments, enhancing skin thickness and elasticity, and helping repair damaged
skin through increased cell turnover and repair processes. For instance, specific hexapeptides like
those found in Nicotinoyl Pentapeptide are linked with improved skin resilience and texture due to their
stimulating effects on fibroblasts, the cells responsible for producing collagen and elastin.
On
the other hand, the nicotinoyl part of this compound, derived from niacin or Vitamin B3, is beneficial
for its skin-brightening and anti-inflammatory properties. Topical niacinamide, a more common form of
nicotinoyl, has been extensively researched and found to significantly improve fine lines and wrinkles,
hyperpigmentation, and skin sallowness, while also enhancing skin barrier function. These attributes are
crucial for a more even skin tone and texture, and overall strengthened skin.
Combining these
components, Nicotinoyl Pentapeptide offers a scientifically-backed approach for addressing multiple skin
concerns. When studied together, this compound potentially offers synergistic benefits, where the whole
becomes more impactful than the sum of its parts. The assistance of the nicotinoyl group in decreasing
inflammation and improving skin hydration complements the peptide's ability to boost collagen and
elastin, leading to comprehensive skin rejuvenation.
While research specifically on Nicotinoyl
Pentapeptide as a singular compound is less abundant than studies on its individual components, the
emerging data and its usage in dermatology suggest promising advantages for varied skin applications.
For consumers seeking evidence-based improvements in skin health without severe side effects, Nicotinoyl
Pentapeptide aligns well with scientific understanding and dermatological practices. Future studies are
likely to furnish more targeted insights into its unique benefits, further establishing its role in
advanced skincare formulations.