Synonym |
L-Citrulline tripeptide |
Species |
Human |
Protein Accession |
NA |
Purity |
Greater than 95% as determined by SDS-PAGE |
Endotoxin Level |
< 0.1 EU per 1 μg of the peptide |
Biological Activity |
NA |
Expression System |
E. coli |
Fusion Tag |
NA |
Predicted Molecular Mass |
317.3 Da |
Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS |
Reconstitution |
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Do not vortex. This solution can be stored at 2-8°C for up to 1 week. |
Storage & Stability |
Store at -20°C. For long-term storage, aliquot and store at -20°C or -80°C. Avoid repeated
freeze-thaw cycles. |
FAQ
What is Tripeptide Citrulline and how does it benefit the skin?
Tripeptide Citrulline is a
cutting-edge ingredient that combines the benefits of citrulline, an amino acid, with tri-peptides,
which are short chains of amino acids that play a crucial role in maintaining skin health. Citrulline is
known for its role in the urea cycle, where it helps to detoxify ammonia, while peptides are essentials
for signaling the skin to produce more collagen. When combined, Tripeptide Citrulline offers a potent
formula that enhances skin hydration, elasticity, and firmness. The unique aspect of this ingredient
lies in its capacity to penetrate deeper skin layers, promoting not only surface hydration but also
long-term skin resilience and renewal.
The hydrating properties of citrulline assist in
maintaining optimal moisture levels in the skin, thus ensuring that the skin barrier remains intact and
protected against environmental stressors. This is particularly beneficial for individuals with dry,
dehydrated, or aged skin, as it helps to keep the skin plump and reduces the appearance of fine lines
and wrinkles. Additionally, through enhanced hydration, Tripeptide Citrulline helps avert transepidermal
water loss (TEWL), thereby enhancing the skin's natural barrier function.
On the other hand, the
peptides in Tripeptide Citrulline stimulate collagen synthesis. Collagen, being the primary structural
protein in the skin, plays a pivotal role in maintaining its firmness and elasticity. By signaling the
skin to produce more collagen, Tripeptide Citrulline significantly contributes to reducing sagging and
promoting a more youthful appearance. Furthermore, increased collagen levels help in minimizing the
visibility of scars, improving overall skin texture.
For individuals dealing with issues such as
dullness or uneven skin tone, Tripeptide Citrulline offers a brightening effect by aiding in cellular
turnover. This ensures that the skin looks vibrant and luminous over time. Another invaluable benefit of
this ingredient is its anti-inflammatory properties, which help in soothing irritated skin, making it
suitable for sensitive skin types prone to redness or irritation.
Lastly, one of the overarching
benefits of using Tripeptide Citrulline is its environmental adaptability. As the skin is subjected to
various stressors ranging from pollution to UV exposure, having an ingredient that strengthens the
skin's resilience is crucial. It prepares the skin to defend and repair itself, leading to better
long-term skin health. Overall, Tripeptide Citrulline is an all-encompassing ingredient that caters to
multiple skin concerns, including hydration, anti-aging, regeneration, and protection.
How does
Tripeptide Citrulline compare to other popular skincare peptides?
Tripeptide Citrulline stands
out amongst other skincare peptides due to its dual-action formula that combines the moisturizing and
clearing benefits of citrulline with the collagen-boosting capabilities of peptides. While many peptides
focus singularly on either collagen production or skin repair, Tripeptide Citrulline offers
comprehensive care encapsulating hydration, anti-aging, and protection properties all at
once.
One of the most common peptides in skincare is Matrixyl, known for its ability to promote
collagen synthesis and skin remodeling. Although effective, Matrixyl lacks the hydrating properties
present in Tripeptide Citrulline owing to its absence of amino acids like citrulline. Hydration is
essential for maintaining not just youthful skin but also for strengthening the skin barrier against
environmental aggressors. Tripeptide Citrulline’s incorporation of citrulline ensures that the skin
receives ample hydration alongside collagen benefits.
Besides Matrixyl, there is Argireline,
known as a 'Botox in a jar', which mimics the effects of botulinum toxin by relaxing facial muscles and
reducing the appearance of wrinkles. However, Argireline primarily targets expression lines and may not
contribute substantially to skin hydration or overall skin health. Tripeptide Citrulline, in contrast,
provides holistic skin benefits—impacting hydration levels, elasticity, and overall skin resilience,
making it an exceptional choice for multi-faceted skincare needs.
Copper peptides, which are
celebrated for promoting healing and collagen synthesis, have a unique drawback relating to potential
skin sensitivity. The presence of copper can sometimes trigger irritation or allergic reactions in
sensitive skin types. Tripeptide Citrulline, enriched with soothing and anti-inflammatory properties,
presents a gentler alternative suitable for sensitive skin while maintaining comparable efficacy in
supporting collagen synthesis and skin renewal.
Another consideration in peptide selection lies
in consistency of results. Some peptides can offer short-term improvements without contributing
substantially to long-term skin health. Tripeptide Citrulline circumvents this by supporting the skin's
own mechanisms to maintain hydration, elasticity, and repair processes from within. Its efficiency in
reinforcing the skin barrier also underscores its preventative qualities against future environmental
damage.
In comparison with other peptides used mainly for specific benefits, Tripeptide
Citrulline brings a versatile, well-rounded approach to skincare. The unique blend addresses multiple
skin concerns in one, creating a broad-spectrum peptide unlike others that boons both cosmetic and
long-term skin health improvements. While individual skins react differently to peptides, the holistic
action of Tripeptide Citrulline lends itself to broader suitability and efficacy, providing tangible
results across various conditions and needs.
What skin types benefit most from using products
containing Tripeptide Citrulline?
Tripeptide Citrulline is a versatile ingredient that can
benefit almost all skin types due to its multi-functional properties. However, certain skin types may
find it particularly advantageous based on its unique capabilities.
For dry and dehydrated skin,
Tripeptide Citrulline is an excellent choice because of its inherent moisturizing properties. The
citrulline component plays a significant role in maintaining the skin's moisture levels, ensuring
hydration is not only promptly provided but also retained. By enhancing the skin's barrier functions, it
helps prevent transepidermal water loss, a common issue in dry skin types. Individuals experiencing
flakiness, tightness, or a rough texture can see marked improvements in skin comfort and smoothness over
time.
Aging skin greatly benefits from Tripeptide Citrulline due to its collagen-boosting
peptides. As the skin ages, natural collagen production diminishes, leading to sagging and a loss of
elasticity. By encouraging collagen synthesis, Tripeptide Citrulline assists in firming and toning the
skin, reducing the appearance of fine lines and wrinkles. For mature individuals, it provides a dual
benefit by addressing both lines and hydration, which are pivotal in maintaining a youthful
complexion.
Individuals dealing with sensitive skin also find Tripeptide Citrulline advantageous,
given its anti-inflammatory properties. The soothing nature helps calm irritation and redness, making it
suitable for those prone to sensitivity due to environmental factors or harsh ingredients. The gentle
nature of this peptide complex allows it to be incorporated into sensitive skincare routines without
negative reactions, promoting more even skin health.
Normal skin types can also incorporate
Tripeptide Citrulline as a preventative measure. It ensures that the skin remains resilient and hydrated
while delaying signs of aging through targeted collagen support. Its ability to enhance the skin's
natural defense mechanisms prepares it against future damage or stress, suitable for maintaining overall
skin health.
Combination skin, which features both oily and dry areas, can also benefit from
Tripeptide Citrulline. Its balancing hydration properties ensure that drier sections are adequately
moisturized without exacerbating oiliness in other areas. By improving overall skin health, it promotes
a balanced and harmonious complexion.
However, individuals with oily skin need not shy away from
Tripeptide Citrulline. While the ingredient imparts hydration, it does not trigger excess oil
production, thus averting clogged pores or breakouts. Its lightweight nature ensures it can be
effectively integrated into an oily skincare routine, enhancing skin texture and resilience without
contributing to oiliness.
Overall, Tripeptide Citrulline is an ideal addition to almost any
skincare regimen. Its ability to cater to different concerns through a unified approach makes it a
standout choice for achieving and maintaining healthy skin across various types.
Can Tripeptide
Citrulline be used alongside other active ingredients?
Certainly, Tripeptide Citrulline can
complement various active ingredients within a skincare routine, enhancing overall efficacy. The
compatibility of this ingredient primarily stems from its gentle and multifaceted properties, which
allow it to integrate seamlessly with other beneficial compounds.
One of the most popular
combinations is with hyaluronic acid. Hyaluronic acid is widely known for its superior hydrating
capabilities, attracting water to the skin's surface. When paired with Tripeptide Citrulline, which also
aids in moisture retention and strengthens the skin barrier, the two amplify each other's
effects—resulting in deeply hydrated, plump, and resilient skin. This combination is particularly
beneficial for dry or dehydrated skin in need of significant moisture boost and
protection.
Vitamin C, another sought-after ingredient for its brightening and antioxidant
properties, works well with Tripeptide Citrulline. While Vitamin C helps in protecting the skin from
free radical damage and promoting an even skin tone, Tripeptide Citrulline can enhance its benefits by
fortifying the skin's hydration levels and elasticity. Together, they offer comprehensive protection and
repair, keeping the skin radiant and smooth.
For anti-aging concerns, combining Tripeptide
Citrulline with retinol can yield impressive results. Retinol, renowned for its ability to accelerate
cellular turnover and promote collagen production, can sometimes be irritating or drying. Tripeptide
Citrulline's moisturizing and soothing properties counteract potential dryness or sensitivity caused by
retinol, making the anti-aging regimen more effective and tolerable.
Niacinamide, known for its
calming and brightening effects, pairs harmoniously with Tripeptide Citrulline. Both aid in
strengthening the skin barrier and reducing redness or irritation, making this duo ideal for sensitive
or reactive skin types. While niacinamide controls oil production and minimizes pores, Tripeptide
Citrulline enhances hydration and elasticity—resulting in refined and balanced skin.
For those
dealing with pigmentation issues, combining Tripeptide Citrulline with alpha arbutin or kojic acid can
enhance skin luminance. Tripeptide Citrulline hydrates and prepares the skin to better absorb
brightening agents, improving overall skin tone. This approach ensures targeted treatments work
optimally where hydration and elasticity are maintained, creating an even and radiant
appearance.
Even exfoliating agents like AHAs and BHAs can be used alongside Tripeptide
Citrulline. While chemical exfoliants help in removing dead skin cells, allowing for clearer and
smoother skin, Tripeptide Citrulline supports the skin's moisture balance and repairs the barrier
function post-exfoliation. This ensures that exfoliation does not lead to irritation, while still
achieving the benefits of regular exfoliation.
When integrating Tripeptide Citrulline with active
ingredients, it's essential to gradually introduce them to monitor skin compatibility and adjust if
needed. Offering versatility and compatibility, this ingredient amplifies the effects of many actives,
ensuring that a well-rounded, effective skincare routine is achieved.
Is Tripeptide Citrulline
safe for pregnant or nursing women?
Skincare during pregnancy or nursing requires careful
consideration, as the skin undergoes various changes, and certain ingredients may affect the developing
fetus or infant. Tripeptide Citrulline, as an innovative skincare ingredient, combines citrulline and
peptides, which individually bear a positive safety profile. However, questions about its safety during
pregnancy or nursing require thorough understanding and ultimately, consultation with a healthcare
provider.
Generally, peptides are regarded as safe for topical use during pregnancy. They are
naturally occurring in the body, promoting collagen production and repair without penetrating deep
enough to impact systemic health. Citrulline is an amino acid involved in the body's metabolic pathways
and is also safely consumed through dietary sources like watermelon. When used in skincare, the
combination in the form of Tripeptide Citrulline primarily targets surface-level skin improvements,
focusing on hydration and elasticity enhancement without interacting with deeper biological
processes.
One of the advantages of Tripeptide Citrulline lies in its mild and non-irritating
nature, making it a potentially suitable component in the skincare regimens for expectant or nursing
mothers. Its hydrating and soothing properties can address common skin concerns during pregnancy, such
as dryness, sensitivity, or dullness, caused by hormonal fluctuations. Additionally, by supporting
barrier function and elasticity, this ingredient can potentially help in managing skin stretching and
discomfort during pregnancy.
Nonetheless, the introduction of new skincare products or
ingredients during pregnancy or nursing should be approached with caution. Although Tripeptide
Citrulline itself does not raise red flags and many dermatologists consider peptides and amino acids
safe, each individual's response to skincare varies, especially with pregnancy-induced skin
sensitivities.
It's advisable to perform a patch test when introducing any new product and
observe the skin's response. Additionally, seeking guidance from a healthcare professional provides
reassurance, as they can offer personalized recommendations tailored to individual health histories and
specific needs. It's not only about the individual ingredient safety but also how it fits into an entire
skincare regimen, taking into account other products used concurrently.
Pregnancy and nursing
primarily necessitate avoidance of certain actives like retinoids or salicylic acid due to their
potential systemic effects. Thus, a focus on safer alternatives with proven benefits facilitates
maintaining skin health without unexpected outcomes. Tripeptide Citrulline, in this context, offers a
harmonious balance of efficacy and gentleness.
Conclusively, while Tripeptide Citrulline appears
to be a promising inclusion in the skincare routine for pregnant or nursing individuals due to its mild,
beneficial profile, professional advice is key to ensuring customization that aligns with personal
health circumstances and addressing unique skincare needs during these special life stages.