Synonym |
(β-Asp3)-GRF (human) |
Species |
Human |
Protein Accession |
P08100 |
Purity |
≥ 95% |
Endotoxin Level |
< 1.0 EU per μg |
Biological Activity |
The ED50 is < 2 ng/mL as measured by a cell proliferation assay using FDC-P1 cells. |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
Approximately 16.9 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS |
Reconstitution |
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
|
Storage & Stability |
Store at -20°C. Upon reconstitution, store at 4°C for up to 2 weeks or freeze in working
aliquots at -20°C to -80°C. |
FAQ
What exactly is (β-Asp3)-GRF (human) and how does it work in the body?
(β-Asp3)-GRF (human) is a
synthetic analog of the naturally occurring human Growth Hormone-Releasing Factor (GRF). This compound
is designed to mimic the action of GRF, which is a peptide hormone responsible for stimulating the
release of growth hormone (GH) from the pituitary gland. Growth hormone plays a crucial role in
regulating growth, metabolism, and overall bodily maintenance. When (β-Asp3)-GRF is used, it interacts
with the pituitary gland's receptors similarly to the natural GRF, prompting it to release more growth
hormone into the bloodstream. This is especially beneficial for individuals who may have deficiencies or
are looking to support normal physical growth and development. By enhancing GH release, (β-Asp3)-GRF can
help in various physiological processes, including increasing bone density, improving muscle mass, and
aiding in the repair and growth of tissues throughout the body. The mode of action involves binding to
the receptors on somatotrophs, specific cells in the anterior pituitary gland, and initiating a cascade
of intracellular events that lead to the synthesis and secretion of growth hormone. This process is
complex and tightly regulated because growth hormone affects numerous downstream metabolic pathways.
With its ability to foster an anabolic environment, (β-Asp3)-GRF can also aid in lipid mobilization and
improve the body's capacity to utilize fat as an energy source, which can be beneficial in body
composition management. It's important to understand that while (β-Asp3)-GRF can mimic the natural
hormone's actions, it should be used under appropriate supervision and guidance to avoid potential
adverse effects and to ensure it fits well within one's health regimen.
What are the potential
benefits of using (β-Asp3)-GRF (human)?
The potential benefits of using (β-Asp3)-GRF (human)
largely stem from its role in stimulating the secretion of endogenous growth hormone. One of the primary
advantages is the promotion of growth and development, which can be especially beneficial for children
experiencing growth deficiencies or for adults looking to improve physical performance or body
composition. By increasing growth hormone levels, (β-Asp3)-GRF can contribute to enhanced muscle mass
and strength. Growth hormone facilitates protein synthesis in the muscles, leading to increased muscle
hypertrophy and lean body mass. This can be particularly advantageous for athletes or individuals
undergoing rehabilitation who seek to accelerate muscle growth and recovery. Another significant benefit
is its impact on bone health. Growth hormone plays a crucial role in bone metabolism, and (β-Asp3)-GRF
can enhance bone density by promoting the proliferation and activity of osteoblasts, the cells
responsible for bone formation. This makes it a valuable tool in managing conditions like osteoporosis,
where bone strength and density are compromised. Additionally, (β-Asp3)-GRF can positively influence fat
metabolism. It aids in the mobilization of fats from adipose tissues and their subsequent use as an
energy source. This not only helps in reducing body fat but also improves overall metabolic health and
energy levels, which is beneficial for individuals looking to manage their weight effectively. In terms
of recovery, (β-Asp3)-GRF can significantly speed up the healing process of tissues and injuries by
promoting the production of collagen and the repair of damaged cells. This makes it a potentially
valuable aid in enhancing post-surgical recovery or the healing of sports-related injuries. Moreover,
there are aging-related benefits, as increased growth hormone levels can support better skin health,
improve sleep quality, and boost overall vitality, potentially counteracting some age-related decline in
physical function. However, while these benefits are compelling, it's essential to approach (β-Asp3)-GRF
use considering individual health profiles and in consultation with healthcare professionals to maximize
its advantages safely.
What are the potential side effects or risks associated with (β-Asp3)-GRF
(human)?
While (β-Asp3)-GRF (human) has numerous potential benefits, there are also associated
risks and side effects that need careful consideration. It's crucial to approach its use with caution
and proper medical supervision. One of the primary concerns with growth hormone-related therapies is the
risk of excessive growth hormone levels, which can lead to conditions such as acromegaly. Acromegaly is
characterized by the abnormal growth of bones and tissues, particularly noticeable in the hands, feet,
and facial features. This condition can also lead to joint pain, thickened skin, and in some cases, more
severe complications such as cardiovascular problems. Improper dosing or unsupervised usage can increase
the probability of these adverse effects. Metabolic alterations are another risk, as elevated growth
hormone levels can induce insulin resistance. This condition can heighten the risk of developing type 2
diabetes, characterized by high blood glucose levels that can cause numerous health issues if unmanaged.
Monitoring blood glucose levels and maintaining a balanced lifestyle can help mitigate this risk. Joint
and muscle pain are also possible side effects, as growth hormone influences musculoskeletal health.
While moderate levels of hormone secretion can improve bone density and muscle mass, excessive
stimulation might lead to pain or discomfort in these areas. This is why dosage and duration of use
should be closely monitored. Moreover, there's a potential risk for carpal tunnel syndrome, a condition
characterized by pain and tingling in the hands and wrists due to nerve compression. Growth hormone can
cause tissue growth around nerves, leading to such nerve-related complications. Lastly, individuals may
experience localized reactions at the injection site, such as redness, swelling, or itchiness. These are
usually mild but serve as a reminder to follow proper administration techniques and hygiene protocols.
Given these potential risks, it’s vital that (β-Asp3)-GRF is used under the guidance of healthcare
professionals who can provide personalized advice and ensure regular monitoring of effects on health
markers, thus optimizing safety and efficacy.
Who could potentially benefit the most from using
(β-Asp3)-GRF (human)?
The potential beneficiaries of (β-Asp3)-GRF (human) usage extend across
various groups, from those with specific medical needs to individuals seeking performance enhancement.
One primary group includes children with growth hormone deficiencies. These deficiencies can stem from
issues within the hypothalamus or pituitary gland, leading to stunted growth and developmental
challenges. By introducing (β-Asp3)-GRF, physicians can stimulate the release of growth hormone, aiding
these children in achieving normal growth patterns and improved bone density and muscle mass. Adults
with diagnosed growth hormone deficiencies can similarly benefit from this therapeutic approach. Such
deficiencies in adulthood might lead to reduced bone density, muscle weakness, and accumulated body fat,
often resulting in lowered energy and psychological stress. With the use of (β-Asp3)-GRF under medical
supervision, these individuals can experience enhanced physical function, better metabolic health, and
improved psychological well-being. Another group that might benefit includes athletes or bodybuilders
aiming to optimize their physical performance and recovery. (β-Asp3)-GRF can help enhance muscle
strength, augment lean body mass, and accelerate recovery from strenuous training sessions or injuries.
Speeding up recovery times allows athletes to train more effectively and potentially achieve their
performance goals more swiftly. Moreover, aging individuals could find (β-Asp3)-GRF beneficial in
countering age-related decline. As people age, natural growth hormone levels tend to decrease, leading
to diminished muscle mass, increased fat accumulation, and a decline in skin vitality. By reinforcing
growth hormone levels, (β-Asp3)-GRF can promote better muscle maintenance, improve skin elasticity, and
potentially slow down some age-associated physiological changes. Lastly, individuals undergoing
substantial surgeries may find benefits in faster recovery and healing times. Growth hormone facilitates
tissue repair and regeneration, allowing patients to restore their normal function and reduce downtime.
However, it’s essential to emphasize that potential users should undergo comprehensive medical
evaluations to ensure (β-Asp3)-GRF suitability, as not everyone may benefit from or tolerate this
hormone optimally. Professional guidance can help tailor its use to individuals’ specific needs,
optimizing benefits and minimizing risks.
How should one approach the administration and dosage
of (β-Asp3)-GRF (human)?
Administering and determining the correct dosage of (β-Asp3)-GRF (human)
involves a delicate balance to maximize its benefits while minimizing any potential risks or side
effects. The approach should always prioritize safety, beginning with a thorough medical evaluation by a
healthcare professional who understands your individual health profile. The dosage of (β-Asp3)-GRF is
typically guided by the specific objectives for its use—whether for addressing growth deficiencies,
enhancing athletic performance, or aiding recovery. A physician would assess the patient’s age, weight,
and specific health needs before determining the appropriate dosing strategy. For children or
individuals with growth deficiencies, dosages are usually calculated based on body weight and the level
of deficiency. It is typically administered via subcutaneous injection, and treatment courses might last
for extended periods, with regular follow-ups to monitor efficacy and adjust doses as required. For
athletes or individuals using (β-Asp3)-GRF for muscle growth or recovery, dosages are usually lower and
administered in cycles to mimic the body's natural growth hormone release patterns. Such cycles help
prevent potential side effects associated with prolonged high levels of synthetic hormone analogs.
During these cycles, it is crucial to monitor physiological responses and adjust dosages accordingly,
ensuring performance gains while maintaining safety. The timing of administration also plays an
essential role. Mimicking the body’s natural circadian rhythm—where growth hormone is typically released
in pulses, often with a peak at night—can enhance the efficacy of (β-Asp3)-GRF. Administering it at
night or before sleep could potentially optimize its growth-promoting and recovery effects in line with
natural hormone peaks. Moreover, practitioners emphasize the importance of rotating injection sites to
prevent skin irritation or adipose tissue degeneration around the areas used for administration. Regular
monitoring through blood tests is vital to gauge hormone levels and metabolic changes, providing vital
feedback that guides further dosing adjustments. Engaging with dieticians or fitness experts may also
form part of a comprehensive administration strategy, combining the (β-Asp3)-GRF treatment with
nutrition and exercise plans to optimize overall health and progress toward goals. By closely
collaborating with healthcare providers and adhering to prescribed plans, users can harness the
potential benefits of (β-Asp3)-GRF effectively and safely.