Synonym |
Mesotocin |
Species |
Ile8-Oxytocin |
Protein Accession |
P01178 |
Purity |
Greater than 98% as determined by SEC-HPLC |
Endotoxin Level |
Less than 1 EU/μg of Ile8-Oxytocin |
Biological Activity |
Activates the oxytocin receptor |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
1007.2 Da |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20% Acetonitrile in water containing 0.1% TFA
|
Reconstitution |
It is recommended to reconstitute the lyophilized Ile8-Oxytocin in sterile 18 MΩ-cm H2O not less
than 100 μg/ml, which can then be further diluted to other aqueous solutions. |
Storage & Stability |
Store lyophilized Ile8-Oxytocin at -20°C. Aliquot the product after reconstitution to avoid
repeated freezing/thawing cycles. |
FAQ
What is (Ile8)-Oxytocin, Mesotocin, and how does it function in the body?
(Ile8)-Oxytocin,
Mesotocin, represents a modified version of the naturally occurring hormone oxytocin, which is primarily
recognized for its roles in social bonding, childbirth, and lactation in mammals. The primary structural
variation lies in its eighth position, where isoleucine is substituted for the typical oxytocin
constituent. This modification potentially alters the molecule's interaction with oxytocin receptors,
maybe enhancing specificity or modulating its biological activity. Oxytocin is a peptide hormone
synthesized in the hypothalamus and stored in the posterior pituitary gland. It plays a critical role in
various physiological and neurological functions. Upon release, oxytocin binds to specific receptors
distributed in several tissues, including the uterus and breasts, facilitating labor contractions and
milk ejection in females. Its social bonding and emotional regulation roles also involve the central
nervous system, influencing areas related to behavior and emotional responses. Interestingly, the
oxytocin family, including mesotocin, appears across several species, including marsupials, reptiles,
and birds, functioning similarly to facilitate reproductive and social behaviors. Understanding how
(Ile8)-Oxytocin fits into this paradigm involves recognizing its potential impact on receptor activity.
This variant may offer unique perspectives in studying conditions ranging from autism spectrum disorders
to anxiety, where oxytocin's modulation of social and emotional circuits is of interest. Despite its
promise, thorough in vivo studies and clinical trials are necessary to validate its effectiveness and
safety across different applications. Hence, while (Ile8)-Oxytocin, Mesotocin, might present a valuable
tool for understanding and possibly modulating oxytocin-related pathways, ongoing research is required
to delineate its full potential and therapeutic implications. Therefore, it is crucial to approach its
study with a mindset open to both its promising possibilities and the limitations that must be addressed
through rigorous scientific inquiry.
What are the potential therapeutic applications of
(Ile8)-Oxytocin, Mesotocin?
(Ile8)-Oxytocin, Mesotocin, given its association with the broader
family of oxytocin hormones, holds significant potential for therapeutic applications across several
medical and psychological domains. One area of strong interest involves the treatment of social and
emotional disorders. Oxytocin is known for its role in facilitating social interactions, trust, and
bonding, suggesting that (Ile8)-Oxytocin could be beneficial in addressing symptoms associated with
conditions like autism spectrum disorders, social anxiety, and other forms of anxiety disorders. By
potentially offering more refined receptor interaction, this variant might modulate neural pathways more
effectively or with fewer side effects compared to standard oxytocin analogs. Moreover, (Ile8)-Oxytocin
might find applications in managing mood disorders, given the evidence supporting oxytocin's involvement
in mood regulation and alleviation of depressive symptoms. Beyond psychiatric and neurological benefits,
(Ile8)-Oxytocin might have implications for reproductive health. Given oxytocin's seminal roles in labor
and lactation, its variant could contribute to treatments for labor induction or augmentation and
challenges in breastfeeding, such as insufficient milk ejection. Moreover, ongoing studies might reveal
its capacity to impact wound healing and cardiovascular health, as oxytocin has been associated with
promoting vasodilation and anti-inflammatory effects. Nevertheless, although the horizons are broad, it
is vital to highlight that concrete clinical evidence supporting these applications remains in
developmental stages. Extensive research involving controlled clinical trials is required to
substantiate these applications' safety, efficacy, and practicality. The unique structural aspects of
(Ile8)-Oxytocin and its interaction with bodily systems propose a promising avenue of research,
potentially leading to novel therapeutic interventions tailored for specific health challenges. Thus,
while the outlook is promising, it rests on a foundational understanding that balances innovative
curiosity with meticulous scientific validation and patient safety considerations.
Could
(Ile8)-Oxytocin, Mesotocin, enhance social bonding and relationships?
The premise that
(Ile8)-Oxytocin, Mesotocin, could enhance social bonding and relationships finds its roots in the
fundamental roles of oxytocin across various animal species, including humans. Oxytocin, often dubbed
the "love hormone," is renowned for its influence on social interactions, trust building, and
relationship dynamics. It plays a substantial role in promoting pair bonding, maternal behaviors, and
attachment beyond the mother-infant relationship into broader social contexts. The use of a variant like
(Ile8)-Oxytocin suggests the potential to fine-tune these interactions more precisely. Modified peptides
like (Ile8)-Oxytocin could engage with the oxytocin receptors differently, possibly leading to enhanced
or modulated effects on social behavior. In context, this might mean more profound impacts on
facilitating empathy, promoting cooperative behavior, and reducing fear or anxiety associated with
social situations, thereby supporting healthier and more constructive interpersonal relationships. In
therapeutic environments, applications of (Ile8)-Oxytocin might show promise in treating conditions
characterized by social deficits, such as autism spectrum disorders or social anxiety, where traditional
pharmacological approaches may fall short. However, it is crucial to approach these propositions with
scientific caution. While the theoretical potential is enticing, empirical evidence demonstrating these
effects in humans and establishing reliable safety profiles is necessary. Human social behavior results
from complex neurological and psychological interplay; hence, any intervention promises must be
evaluated for breadth and nuance. Considerations of possible side effects and individual variability in
response also warrant thorough research. While the discourse surrounding its capabilities to enhance
social bonding and improve relationships is encouraging, it must be substantiated with evidence-based
research and aligned with comprehensive ethical frameworks. Therefore, the potential of (Ile8)-Oxytocin
as a tool to enhance social relationships remains an active area of exploration, promising but
intricately tied to thorough and responsible scientific inquiry.
How does the delivery method
of (Ile8)-Oxytocin, Mesotocin, impact its effectiveness?
The delivery method of (Ile8)-Oxytocin,
Mesotocin plays a critical role in determining its effectiveness and clinical viability. Similar to
other peptide hormones, (Ile8)-Oxytocin may face challenges related to stability and bioavailability,
which necessitates careful consideration of the ways it is administered to achieve the desired
biological effects. Generally, peptide-based treatments confront hurdles related to oral administration
due to enzymatic degradation in the gastrointestinal tract, usually making oral delivery unfeasible. As
a result, alternative methods like nasal, intravenous, or subcutaneous routes are often explored for
administering such biologically active molecules. Each method has distinct advantages and limitations,
shaping the therapeutic outcome. Intranasal delivery is a notable means of administering oxytocin and
its analogs, like (Ile8)-Oxytocin, because it offers a non-invasive approach and the capacity for
molecules to reach central nervous system targets more directly via the olfactory pathway. This method
potentially circumvents the blood-brain barrier, which may otherwise limit the peptide’s access to brain
regions regulating social and emotional behaviors. This direct pathway makes intranasal administration
appealing for applications like modulating mood or enhancing social interaction capabilities.
Conversely, intravenous or subcutaneous routes might be selected for systemic effects, requiring precise
dosing and administration in controlled settings, usually necessitating medical supervision. The chosen
delivery path must also align with the intended therapeutic objectives, whether targeting central
neurological authorities or eliciting systemic physiological responses. Moreover, the mode of delivery
can affect patient compliance, comfort, and overall treatment feasibility in practical settings,
impacting acceptance by patients and healthcare providers alike. Understanding these modalities’
complexities and refining them through ongoing research and technological innovations remains central to
maximizing (Ile8)-Oxytocin's therapeutic utility. Ultimately, the delivery method’s influence over
treatment success underscores the broader canvas of research and development necessary to harness the
potential of (Ile8)-Oxytocin, Mesotocin.
What are the ethical considerations surrounding the
use of (Ile8)-Oxytocin, Mesotocin?
The exploration of (Ile8)-Oxytocin, Mesotocin, much like any
potent biologically active compound, navigates through various ethical considerations crucial to
responsibly harnessing its potential benefits while safeguarding individual rights and societal norms.
As a molecule displaying possible effects on social behavior and emotional states, using this hormone
analog invokes discussions central to ethics in pharmacotherapy and neuroenhancement. Primarily, the
issues of consent and autonomy strongly require attention. Ensuring individuals fully comprehend the
implications of using such intervention to potentially modify their social behavior or emotions is
essential. This raises questions around the threshold of informed consent when dealing with capacities
to influence cognitive and emotional domains, particularly in vulnerable populations such as the
mentally ill or minors. In navigating therapeutic environments or enhancement contexts, safeguarding
against coercion or undue influence remains particularly pertinent. Furthermore, the potential for
misuse as a social enhancer involves deeper ethical scrutiny. Deploying (Ile8)-Oxytocin to manipulate or
enhance social behaviors could lead to scenarios where distinctions between therapeutic interventions
and lifestyle enhancements blur, challenging regulatory standards and ethical frameworks that govern
pharmaceutical use. Equally, the concerns over equity and access emerge prominently. Ensuring that
advances linked to (Ile8)-Oxytocin do not engender disparities in health equity or social advantage
aligns with broader ethical commitments to justice and fairness in healthcare delivery. The
communication surrounding the risks, benefits, and the scope of possible outcomes also demands
responsible handling, emphasizing transparency and accuracy without overstating capabilities or
fostering unrealistic expectations. Thus, addressing these ethical dimensions involves comprehensive,
multidisciplinary dialogues involving ethicists, scientists, clinicians, and the public. The broader
societal impacts, balancing innovation with caution, and extending ethical responsibility beyond
individual users to collective contexts, underscore the ongoing need for robust frameworks within which
(Ile8)-Oxytocin, Mesotocin might find its appropriate boundaries and applications.