Synonym |
4-Nitro-Z-GWG-OH |
Species |
N/A |
Protein Accession |
N/A |
Purity |
≥95% |
Endotoxin Level |
<1.0 EU per µg |
Biological Activity |
N/A |
Expression System |
N/A |
Fusion Tag |
N/A |
Predicted Molecular Mass |
495.0 Da |
Formulation |
Supplied as a lyophilized powder |
Reconstitution |
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 1 mg/ml. |
Storage & Stability |
Store at -20°C upon arrival. It is recommended to store at -20°C or -80°C. Avoid repeated
freeze-thaw cycles. |
FAQ
What is 4-Nitro-Z-GWG-OH and what are its primary applications?
4-Nitro-Z-GWG-OH is a specialized
chemical compound often used in research and development fields. It is known for its distinct nitro
group, which provides it with unique reactive properties. This compound is primarily utilized within
biochemical and pharmaceutical research domains. Its primary applications include acting as an
intermediate in the synthesis of peptides and proteins, where it plays a crucial role in facilitating
peptide bond formation. Given its structure, 4-Nitro-Z-GWG-OH is particularly useful in complex
synthesis processes which require highly selective reactivity. Furthermore, this compound is frequently
employed in the development of novel pharmaceuticals, owing to its versatility and stable properties.
Researchers appreciate its stability under a range of conditions, which is a critical characteristic
when attempting to manipulate complex chemical pathways. By working with 4-Nitro-Z-GWG-OH, scientists
can explore alternative reaction mechanisms, with the nitro group enabling various substitution
reactions that are valuable in synthetic chemistry. Moreover, given the current focus on developing new
medicinal products, 4-Nitro-Z-GWG-OH is integral to identifying potential drug candidates, as it can
help in the creation of peptide-like molecules aimed at targeting a vast array of biological pathways.
It contributes significantly to innovation in drug design, particularly in the quest for new treatments
for conditions such as chronic diseases and infections. Ultimately, researchers prize 4-Nitro-Z-GWG-OH
for its reliability and efficiency in advancing chemical synthesis and drug development projects, making
it a staple in contemporary scientific endeavors.
How does 4-Nitro-Z-GWG-OH contribute to
advancements in peptide synthesis?
Peptide synthesis is a pivotal process in the creation of many
pharmaceuticals and biochemical studies. 4-Nitro-Z-GWG-OH plays a critical role in this domain due to
its ability to streamline and enhance peptide bond formation. The design of 4-Nitro-Z-GWG-OH includes a
nitro group that is particularly reactive, allowing for a selective series of reactions that are vital
in complex peptide synthesis. This selectivity is incredibly advantageous because it allows researchers
to construct peptides with fewer undesired by-products, which is a step forward in achieving higher
purity and yield in peptide production. By facilitating the creation of clear reaction paths,
4-Nitro-Z-GWG-OH minimizes the challenges associated with contaminant compounds that typically arise
during peptide synthesis. Furthermore, it aids in stabilizing the intermediary compounds that are prone
to degradation or interference within the process. As a consequence, it essentially enhances the
efficiency of the entire peptide synthesis pathway. From a practical standpoint, scientists can apply
4-Nitro-Z-GWG-OH in the synthesis of both short and long-chain peptides, making it a versatile agent in
multiple types of molecular designs. Moreover, given that peptides often require very specific sequences
to ensure efficacy, the high selectivity of 4-Nitro-Z-GWG-OH provides scientists with an invaluable tool
for the precise construction of functional peptides, which holds immense potential for therapeutic
applications. Peptides synthesized with 4-Nitro-Z-GWG-OH find utility not only in medication but also in
vaccine development, diagnostic tools, and more. Overall, its contribution to peptide synthesis is a
testament to the advanced capabilities this compound introduces to the field, significantly propelling
forward the possibilities of peptide-based research and its applications in real-world
solutions.
What characteristics of 4-Nitro-Z-GWG-OH make it suitable for pharmaceutical
research?
In pharmaceutical research, the choice of compounds for synthesis and analysis must be
precise, as it dictates the potential of therapeutic development and effectiveness. 4-Nitro-Z-GWG-OH is
distinguished by its distinct chemical properties, which make it an ideal candidate in this field.
Firstly, its chemical stability is paramount. The compound, endowed with a nitro group, exhibits a high
tolerance to a variety of conditions, including variations in pH and temperature. This robustness is
essential for pharmaceutical applications, where processes might involve extreme environments to test
reactions and performance. Such stability ensures that the integrity of 4-Nitro-Z-GWG-OH is maintained
throughout, allowing for consistent results in experimental setups. Secondly, the compound’s reactivity
is crucial, specifically the potential of the nitro group to take part in complex synthetic routes. This
reactivity allows 4-Nitro-Z-GWG-OH to be incorporated as a key intermediate for synthesizing complex
molecular structures pertinent to drug development. As researchers attempt to develop new therapeutics,
often there is a need for an intricate assembly of the drug molecule, requiring specific sequences and
functional groups in place. 4-Nitro-Z-GWG-OH aids in this assembly, particularly in the creation of
peptide-like drugs known for targeting specific proteins or pathways in the body. Moreover, the
compound's relatively straightforward functionalization opportunities afford scientists the flexibility
to modify drug candidates easily, enhancing pharmacological properties such as solubility and
bioavailability. Lastly, 4-Nitro-Z-GWG-OH's recognized selectivity in reactions is highly beneficial,
allowing for targeted synthesis with minimal side reactions – a feature that not only improves
efficiency but also reduces costs related to purification and waste management in pharmaceutical
processes. Overall, the beneficial characteristics of 4-Nitro-Z-GWG-OH align perfectly with the rigorous
demands of pharmaceutical research, making it an indispensable component in new drug development
pipelines.
How does the nitro group in 4-Nitro-Z-GWG-OH enhance its functionality?
The
nitro group in 4-Nitro-Z-GWG-OH is a critical feature that greatly enhances the compound's functionality
in several ways. Typically, a nitro group, which consists of one nitrogen atom bonded to two oxygen
atoms, is featured in a variety of chemical compounds that require increased reactivity and versatility.
In the context of 4-Nitro-Z-GWG-OH, the presence of the nitro group significantly boosts the compound’s
electron-withdrawing capabilities. This electron-withdrawing property plays a crucial role in
facilitating reactions that are highly specific in nature. For instance, during synthesis processes, the
nitro group can shift the electron density within the molecule, thereby accentuating reactivity in
adjacent molecular sites. This heightened reactivity results in the compound’s ability to undergo
selective reactions, which is particularly advantageous in peptide synthesis and modification. The nitro
group's presence also increases the stability of intermediates formed during chemical reactions.
Stability here means a reduced chance of unwanted degradation and side reactions, which are common
hurdles in synthesis and can lead to inefficiencies. By helping to stabilize intermediates, the nitro
group allows for smoother transition states and encourages reaction pathways to proceed toward the
desired product more effectively. Furthermore, in the broader scope of organic synthesis, nitro groups
can participate in various transformation reactions like reduction, enabling the strategic introduction
of additional functionalities. Such functional transformations are key in developing complex molecules
required for advanced applications like drug design. Additionally, the unique spectroscopic
characteristics imparted by the nitro group can facilitate easier analysis and monitoring of the
compound and its reactions through various methods like NMR or mass spectrometry. This level of control
and predictability is invaluable in both research and industrial settings where precise and reliable
reaction outcomes are imperative. In essence, the nitro group is a fundamental element of
4-Nitro-Z-GWG-OH, enhancing its utility and functionality across multiple dimensions of chemical and
pharmaceutical applications.
What safety precautions should be observed when handling
4-Nitro-Z-GWG-OH?
Handling chemical compounds such as 4-Nitro-Z-GWG-OH requires a thorough
understanding of safety precautions to ensure effective use while safeguarding health and environmental
conditions. First and foremost, it is essential to conduct any work with 4-Nitro-Z-GWG-OH within a
laboratory setting equipped with proper ventilation systems, such as a fume hood. This measure is
crucial in preventing the inhalation of any potentially harmful vapors or airborne particulates that may
emanate from the compound. Personnel involved in handling this compound must wear appropriate personal
protective equipment (PPE), including lab coats, gloves made from suitable material resistant to
chemicals, and safety goggles. The right PPE acts as a barrier between the skin and the compound,
thereby minimizing risks of skin contact and associated chemical burns or allergic reactions. Additional
protective measures may include using respirators where necessary, especially if there is a risk of
inhaling dust or mist. It is also important to store 4-Nitro-Z-GWG-OH properly, away from direct
sunlight and in a cool, dry environment to maintain its stability. Containers used for storing this
compound should be tightly sealed to avoid any moisture ingress or accidental spillage. Equally,
secondary containment measures such as using spill trays are recommended to minimize contamination risks
and facilitate easy cleanup in case of accidental leaks. During the handling process, clear labeling of
the compound is vital to prevent mix-ups with other chemicals that might react adversely. In terms of
disposing of waste or excess material, one must follow the local regulations and guidelines for
hazardous waste management to prevent environmental contamination. Additionally, having an emergency
procedure in place is critical. This involves ensuring easy access to emergency showers and eye wash
stations, making spill kits readily available, and training all personnel in emergency response
protocols relevant to chemical handling. Proper documentation and communication of safety data sheets
(SDS) for 4-Nitro-Z-GWG-OH should be readily accessible to all users to reinforce an understanding of
the risks and safety measures associated with this chemical. By observing these precautions, one can
safely handle 4-Nitro-Z-GWG-OH while minimizing the potential risks inherent when working with chemical
substances.