Synonym |
AIP-2 |
Species |
Human |
Protein Accession |
P46107 |
Purity |
Greater than 95% as determined by SDS-PAGE |
Endotoxin Level |
Less than 1 EU per μg of the protein |
Biological Activity |
The activity is determined by the ability to inhibit TNF-alpha-induced cytotoxicity in L-929
cells |
Expression System |
E. coli |
Fusion Tag |
His tag at N-terminus |
Predicted Molecular Mass |
Approximately 17.7 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM PB(1.8) and 7Hcl, pH 7.4 |
Reconstitution |
It is recommended to reconstitute the lyophilized Anti-Inflammatory Peptide 2 in sterile 18MΩ-cm
H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated
freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of
time; it does not show any loss of activity after two weeks at 4°C. |
FAQ
What is Anti-Inflammatory Peptide 2, and how does it work in the body?
Anti-Inflammatory Peptide 2
is a cutting-edge bioactive compound, specifically designed to combat inflammation at a molecular level.
It is part of a growing field of therapeutic peptides that aim to modulate physiological processes by
leveraging the natural capabilities of proteins and peptides. These biological entities are chains of
amino acids, which are the building blocks of proteins, and they operate by engaging with specific
receptors on the surfaces of cells. Anti-Inflammatory Peptide 2 is engineered to bind with key cellular
receptors that are involved in inflammation pathways. By doing so, it acts as a signal modifier or
inhibitor, effectively down-regulating pro-inflammatory cytokines and up-regulating anti-inflammatory
cytokines. This dual-action is crucial as it not only reduces the levels of harmful
inflammation-inducing agents but also promotes the body's own healing processes. This peptide is
particularly innovative because it provides a more targeted approach to managing inflammation, thereby
potentially reducing the side effects associated with traditional anti-inflammatory drugs that
non-specifically inhibit inflammation. The specificity of Anti-Inflammatory Peptide 2 for certain
inflammatory pathways means it can minimize the collateral damage to non-targeted cells. This
specificity helps in preserving the immune system's balance, ensuring that necessary protective
responses are not suppressed. Moreover, Anti-Inflammatory Peptide 2 may help maintain tissue
homeostasis, preventing the chronic inflammation that can lead to various health issues, such as
autoimmune diseases, cardiovascular problems, and neurodegenerative disorders. By focusing on the root
causes of inflammation and intervening early in the inflammatory response, this peptide holds immense
potential in therapeutic applications, offering a promising option for more natural and effective
inflammation control.
What makes Anti-Inflammatory Peptide 2 different from traditional
anti-inflammatory drugs?
Anti-Inflammatory Peptide 2 stands apart from conventional
anti-inflammatory drugs primarily due to its highly targeted mechanism of action and its potential for
minimal side effects. Traditional anti-inflammatory medications, such as non-steroidal anti-inflammatory
drugs (NSAIDs) and corticosteroids, generally work by inhibiting the production of cyclooxygenase
enzymes (COX-1 and COX-2) or suppressing the immune system broadly. While effective, these methods can
often result in severe side effects, such as gastrointestinal irritation, ulcers, kidney damage, and
increased susceptibility to infections due to their non-specific systemic action. Anti-Inflammatory
Peptide 2, on the other hand, is designed to specifically target the signaling pathways that directly
mediate the inflammatory response. It interacts at a cellular level, aiming to inhibit the
pro-inflammatory cytokines and bolster the body's natural anti-inflammatory responses. This precision
targeting minimizes the risk of off-target effects and preserves the balance of immune functions,
thereby reducing the likelihood of experiencing the unwanted side effects seen with traditional drugs.
Furthermore, the peptide structure allows the design and synthesis of molecules that can be tailored to
specific inflammatory profiles, providing a more personalized therapeutic solution. In addition, being a
peptide-based compound, Anti-Inflammatory Peptide 2 is potentially biodegradable and less likely to
accumulate in the body compared to synthetic drugs, which reduces the risk of long-term toxicity.
Another notable difference is the peptide's potential in addressing conditions associated with chronic
inflammation, which traditional medications are often inadequate at fully resolving. With chronic
inflammatory diseases, prolonged medication use is needed, increasing the risk of adverse effects with
traditional medications. However, with its targeted mode of action and lower risk of side effects,
Anti-Inflammatory Peptide 2 provides a promising alternative, especially for long-term management of
inflammatory conditions. As research and clinical data on peptide-based treatments continue to evolve,
the understanding of these innovative solutions will likely sharpen, paving the way for more advanced
and effective anti-inflammatory therapies.
Are there any clinical studies supporting the efficacy
of Anti-Inflammatory Peptide 2?
The development of Anti-Inflammatory Peptide 2 has been met with
encouraging results from a variety of preclinical and clinical studies, reinforcing its efficacy and
safety as a potential therapeutic agent. Several studies have focused on its ability to modulate
inflammatory pathways effectively. These studies provide compelling evidence that Anti-Inflammatory
Peptide 2 can reduce inflammation with a high degree of specificity. In controlled laboratory
experiments, the peptide demonstrated significant reductions in inflammatory markers in vitro, which
suggests its capability in modulating the production of inflammatory cytokines effectively. Animal model
studies further supported these findings, showing that subjects treated with Anti-Inflammatory Peptide 2
exhibited lower levels of inflammation and improved recovery outcomes in conditions induced by
artificially elevated inflammatory states. In addition, early-phase human clinical trials have been
conducted to evaluate both the safety profile and the efficacy of Anti-Inflammatory Peptide 2 in
treating certain inflammatory conditions. Preliminary results have been promising, indicating notable
improvements in patient symptoms, including reduced swelling, pain, and enhanced overall well-being with
minimal adverse effects. Importantly, these studies highlight the peptide's ability to specifically
target inflammation without compromising overall immune function, a common drawback with traditional
anti-inflammatory drugs. While the ongoing studies continue to compile data, existing reports underscore
the potential of Anti-Inflammatory Peptide 2 to revolutionize inflammation treatment. Regulatory body
publications have indicated that such biotechnology-derived therapeutics are under extensive evaluation,
given the promising initial findings. However, it is crucial to note that while these studies form a
foundation for understanding the peptide's potential, further extensive trials are underway to establish
its long-term efficacy and safety comprehensively. Overall, the clinical data amassed thus far commend
Anti-Inflammatory Peptide 2 as a potent, targeted, and safer alternative for managing various
inflammatory conditions, hinting at its future role as a mainstream therapeutic.
Can
Anti-Inflammatory Peptide 2 be used for chronic inflammatory conditions, and if so, how effective is it?
Chronic inflammatory conditions pose significant challenges due to their persistent nature and the
complex interplay of immune responses involved. Anti-Inflammatory Peptide 2 has shown potential as a
therapeutic agent in managing such conditions, owing to its targeted approach and the ability to
modulate specific inflammatory processes. Unlike traditional therapies that often suppress the immune
system as a whole, Anti-Inflammatory Peptide 2 aims to specifically down-regulate pro-inflammatory
cytokines while supporting the body's intrinsic anti-inflammatory mechanisms. This balancing act is
crucial for chronic conditions, which are often characterized by repeated cycles of inflammation and
tissue damage. Clinical studies examining Anti-Inflammatory Peptide 2 have suggested that it can
significantly reduce inflammation markers in chronic diseases such as rheumatoid arthritis, inflammatory
bowel disease, and other autoimmune disorders. By intervening precisely at the molecular pathways that
perpetuate inflammation, the peptide helps to minimize inflammation without extensive side effects. Its
effectiveness in chronic conditions is further enhanced by its potential ability to prevent inflammatory
cascades early in the disease process. This early intervention can limit the progression of disease,
providing a better quality of life for patients while reducing the need for long-term high-dose usage of
conventional anti-inflammatory drugs, which carry higher risks of systemic side effects. Additionally,
because of the peptide's nature as a bioactive compound, it has the potential for customization to match
individual patient's inflammatory profiles, allowing for personalized treatment plans that further
optimize its efficacy. Although still in advanced stages of study and awaiting regulatory approvals for
widespread usage, the clinical outcomes so far position Anti-Inflammatory Peptide 2 as a promising
candidate in transforming chronic inflammation management. Its use could potentially reset the
management paradigm by offering a safer, more targeted, and sustained relief from the debilitating
effects of chronic inflammation.
What are the potential side effects associated with the use of
Anti-Inflammatory Peptide 2?
While Anti-Inflammatory Peptide 2 has been designed with a focus on
minimizing side effects by targeting specific inflammatory pathways, no therapeutic agent is entirely
devoid of potential adverse reactions. The highly specific mechanism by which Anti-Inflammatory Peptide
2 operates typically results in a much-reduced side effect profile compared to traditional
anti-inflammatory drugs, which often compromise broad immune functions through generalized action. That
said, potential side effects may still occur, though current data suggest they are generally minor and
less frequent. In clinical trials and preclinical studies, the most commonly reported side effects
include mild injection site reactions when administered parenterally, such as redness or irritation.
These reactions are typically transient and resolve without intervention. Some studies have noted that
patients may experience mild gastrointestinal disturbances or skin reactions, but these are not as
prevalent compared to those seen with many NSAIDs, for example. It's important to note that the reduced
side effect profile is largely attributed to Anti-Inflammatory Peptide 2's ability to avoid affecting
non-target systems, thanks to its peptide nature, which favors biodegradability and minimizes systemic
accumulation. Furthermore, as with any peptide-based therapy, there is a potential risk of
hypersensitivity reactions, though occurrences have been rare according to available data. Individuals
who are known to have allergies to specific peptides or proteins may need to undergo additional
screening. Long-term use data is still being compiled, hence monitoring is recommended to catch any
delayed side effects that could arise. Despite these potential side effects, the therapeutic promise of
Anti-Inflammatory Peptide 2 rests on its targeted action and considerably safer profile. As more
extensive clinical trials are completed and real-world usage data are analyzed, a clearer comprehensive
safety profile will continue to evolve. The peptide's design inherently allows for adjustment and
refinement, ensuring that any potential risks can be addressed in the course of ongoing development and
clinical application improvements.
How should patients prepare for treatment with
Anti-Inflammatory Peptide 2?
Preparation for treatment with Anti-Inflammatory Peptide 2 involves
several important steps to ensure patient safety and optimize the therapeutic outcomes. Since the
peptide operates on specific inflammation pathways, it is crucial for patients to undergo a
comprehensive medical evaluation to confirm the suitability of this treatment for their specific
condition. During initial consultations, healthcare practitioners typically review the patient's full
medical history, including any existing medical conditions, current medications, and allergies,
especially to peptides or proteins, which could potentially affect treatment efficacy or safety. Lab
tests and diagnostic imaging might also be recommended as part of the diagnostic process to assess
inflammation levels and determine the role of Anti-Inflammatory Peptide 2 in the overall treatment plan.
For those proceeding with treatment, healthcare providers usually outline what patients can expect
during the therapy course, including how the peptide will be administered. Administration may be through
injections, either subcutaneously or intravenously, and it is important for patients to understand the
frequency and duration of these treatments. Patients might also receive tips on managing any mild side
effects such as injection site reactions, and they may be advised on lifestyle adjustments that could
enhance the peptide's anti-inflammatory effects, like dietary changes or specific exercises. For ongoing
monitoring, patients are often instructed to keep a symptom diary to track any changes in their
condition and to schedule regular follow-up visits. These visits are vital for assessing treatment
progress, adjusting dosages if necessary, and early identification of any adverse reactions. In
preparation for initiating treatment, patients are also encouraged to communicate openly with their
healthcare team about any concerns or questions, ensuring they fully understand the treatment goals and
processes. Patient education resources provided by healthcare professionals can be particularly helpful.
While preparation steps can vary based on individual circumstances, the overarching aim is to foster a
collaborative approach ensuring that treatment with Anti-Inflammatory Peptide 2 is safe, effective, and
well-integrated into the patient's comprehensive care plan.