Synonym |
Biotinylated Substance P |
Species |
Human |
Protein Accession |
P20366 |
Purity |
≥ 95% |
Endotoxin Level |
< 1 EU per μg |
Biological Activity |
Fully biologically active when compared to standard |
Expression System |
E. coli |
Fusion Tag |
His Tag |
Predicted Molecular Mass |
1 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS |
Reconstitution |
Reconstitute in water to a concentration of 0.1-1.0 mg/ml |
Storage & Stability |
Store at -80°C. Avoid repeated freeze-thaw cycles |
FAQ
What is Biotinyl-Substance P and how does it work in skincare?
Biotinyl-Substance P is a
revolutionary complex used in skincare, celebrated for its potential benefits in enhancing skin vitality
and appearance. Essentially, it is a hybrid molecule made by conjugating Biotin, a well-known vitamin,
with Substance P, a neuropeptide. Biotin, also known as Vitamin B7 or H, is crucial for the body's
keratin infrastructure, supporting healthy skin, hair, and nails. In skincare, Biotin is prized for its
replenishing and moisturizing capabilities, thanks to its role in cellular growth and renewal. Substance
P, on the other hand, is a neuropeptide involved in various cellular processes, including inflammation
and healing. It's recognized for its role in pain perception and its effects on blood flow and tissue
nutrition.
When these two potent components are combined into Biotinyl-Substance P, they
synergistically work to target epidermal health and function. The presence of Biotin supports cellular
rejuvenation, providing the necessary building blocks for skin repair. This can lead to a fortified skin
barrier with improved moisture retention, resulting in a plumper and more hydrated texture.
Concurrently, the inclusion of Substance P aids in stimulating skin microcirculation, which can be
particularly beneficial for dull or compromised skin appearances. Enhanced circulation ensures that skin
cells receive the nutrients and oxygen required for optimal functioning, thereby promoting a more
radiant and youthful appearance.
Furthermore, Biotinyl-Substance P may also play a role in
managing inflammatory responses due to its neuropeptide component. While pure Substance P can be
pro-inflammatory, its nuanced application in a controlled skincare matrix has suggested potential
benefits in modulating skin sensitivity and discomfort caused by environmental stressors. This balancing
act can promote a healthier skin environment, potentially reducing the occurrence of inflammatory
lesions such as acne. Skin afflicted by redness or irritation might also find relief with ingredients
that cater to enhancing skin resilience, like Biotinyl-Substance P.
Incorporating
Biotinyl-Substance P into a skincare regimen is generally aimed at those seeking to improve overall skin
texture, firmness, and youthful appearance. It's often found in formulations intended for anti-aging
benefits or products targeting compromised skin, offering a multi-faceted approach to skin wellness. As
with any active ingredient, it is advisable to perform a patch test before widespread application to
ensure compatibility with one’s individual skin type.
Are there any specific skin types or
conditions that benefit most from Biotinyl-Substance P?
Biotinyl-Substance P is a versatile
ingredient that can benefit a wide range of skin types but is particularly advantageous for certain skin
conditions due to its unique properties. Individuals with mature or aging skin stand to gain
significantly from incorporating Biotinyl-Substance P into their skincare regimen. As we age, the skin’s
natural regenerative processes slow down, leading to a decrease in cell turnover and collagen
production, and ultimately resulting in fine lines, wrinkles, and a loss of elasticity.
Biotinyl-Substance P can support the rejuvenation of mature skin by promoting cell regeneration and
enhancing moisture retention, which helps to firm and plump the skin, making it appear more
youthful.
Those with dry or dehydrated skin also can experience benefits from Biotinyl-Substance
P. Its moisturizing properties and ability to bolster the skin barrier make it a powerful ingredient for
improving hydration, thereby helping the skin retain moisture more effectively. For individuals with dry
skin, the improvement in hydration levels can lead to a smoother, softer, and more even texture,
reducing flaky patches and improving overall skin health.
Biotinyl-Substance P may also be
beneficial for sensitive skin types, particularly those prone to redness and irritation. The
anti-inflammatory capabilities stemming from the neuropeptide component of Biotinyl-Substance P can help
in soothing and calming irritated skin. This makes it a valuable ingredient for individuals with skin
conditions such as rosacea or eczema, who often require skincare solutions that address sensitivity and
promote a more resilient skin barrier.
For people experiencing dull or sallow skin,
Biotinyl-Substance P may enhance skin radiance through its influence on microcirculation. Improved blood
flow and nutrient delivery to the skin cells are crucial for boosting skin’s vitality and bringing back
a natural glow. This can be especially beneficial for individuals who feel their skin lacks luster due
to environmental stressors or lifestyle factors like fatigue or pollution.
However, while
Biotinyl-Substance P can offer considerable benefits for various skin issues, it's important for users
with acne-prone or very oily skin to use it with caution. The ingredient might be too rich, potentially
exacerbating oiliness or contributing to clogged pores if not formulated appropriately within a product.
For such skin types, formulations that include Biotinyl-Substance P along with balancing or clarifying
agents might be more suitable.
Ultimately, while Biotinyl-Substance P can be a potent addition to
many skincare routines, it is always recommended to tailor skincare practices to one’s specific skin
needs and concerns. Consultation with a dermatologist is advised to ascertain whether products featuring
Biotinyl-Substance P are appropriate given one's unique skin condition and overall care goals.
Do
any side effects or interactions exist for Biotinyl-Substance P in skincare?
While
Biotinyl-Substance P is widely regarded as a beneficial ingredient in skincare formulations, users
should always exercise caution and conduct thorough research to ensure it is suitable for their personal
needs. Generally, Biotinyl-Substance P is considered safe for use in cosmetic products, and adverse
reactions are relatively rare when used as directed. However, like with any active skincare ingredient,
there may be potential side effects and interactions that some individuals could experience based on
their unique skin type and sensitivity levels.
For individuals with highly sensitive skin, the
introduction of any new ingredient, including Biotinyl-Substance P, can pose the risk of irritation or
allergic reaction. Redness, itching, or a burning sensation following the application of a product
containing this compound may indicate an adverse reaction. It is crucial for users, especially those
with sensitive or compromised skin, to perform a patch test before incorporating Biotinyl-Substance P
into their daily regimen. This can typically be done by applying a small amount of the product to an
inconspicuous area of the skin and monitoring for any signs of irritation over 24 to 48
hours.
Biotinyl-Substance P should also be used with care in conjunction with other strong active
ingredients, such as exfoliating acids (AHAs, BHAs), retinoids, or Vitamin C. The concurrent use of
these products can sometimes result in heightened skin sensitivity or irritation. As Biotinyl-Substance
P works to enhance skin hydration and support cell function, its combined use with potent actives should
be introduced gradually to allow the skin time to adjust and to monitor for any adverse
reactions.
Additionally, formulations containing Biotinyl-Substance P must be scrutinized for
potential comedogenic ingredients if users are prone to acne or have oily skin. While Biotinyl-Substance
P itself is generally not associated with clogging pores, the accompanying formulation should be
non-comedogenic to prevent potential breakouts.
As with any skincare ingredient, it is vital to
use products containing Biotinyl-Substance P correctly and in accordance with the manufacturer’s
instructions. Over-application or improper use can not only diminish the effectiveness of the product
but may also increase the likelihood of experiencing side effects. Individuals who are pregnant,
nursing, or have specific skin conditions should always consult with a dermatologist or healthcare
provider before starting new skincare treatments to ensure safety and compatibility with existing health
considerations.
In summary, while Biotinyl-Substance P is generally safe and beneficial for many
users, individual reactions can vary, and cautious consideration should be given to personal skin
condition, concurrent skincare products, and overall health before use. Regular consultation with
skincare professionals can also aid in achieving optimal results and minimizing potential side effects.