Synonym |
Bz-NGT-NH2 |
Species |
Human |
Protein Accession |
Not available |
Purity |
Greater than 95% |
Endotoxin Level |
Less than 1 EU per 1 μg of the protein |
Biological Activity |
Not specified |
Expression System |
Escherichia coli |
Fusion Tag |
Not applicable |
Predicted Molecular Mass |
Approximately 3.5 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS |
Reconstitution |
Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration
not less than 100 μg/ml |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot and store at -20°C or -80°C for long-term storage.
Avoid repeated freeze/thaw cycles. |
FAQ
What is Bz-NGT-NH2 and what are its primary uses?
Bz-NGT-NH2, an important synthetic compound, is
utilized widely in various fields of chemical and pharmaceutical industries due to its unique
properties. As a chemical intermediate, Bz-NGT-NH2 serves as a building block in the synthesis of more
complex molecules. In pharmaceutical contexts, this compound is valuable for its utility in the
development and manufacture of active pharmaceutical ingredients (APIs). The presence of the NH2 group,
a primary amine, is crucial because it allows for further chemical modifications, which are essential in
creating diverse drug formulations.
Pharmaceutical companies leverage Bz-NGT-NH2 in drug
discovery and development because its chemical structure can be foundational for designing molecules
that interact with specific biological targets. For researchers and developers, the versatility offered
by Bz-NGT-NH2 facilitates the exploration of various avenues in drug synthesis, providing a basis to
test compounds for antimicrobial, antiviral, or anticancer activity among other therapeutic potentials.
Additionally, Bz-NGT-NH2 is often explored in academic and industrial research settings for its
potential applications in creating new materials that may have significant technological
advancements.
In addition to pharmaceuticals, the uniqueness of Bz-NGT-NH2 can be exploited in
the production of specialty chemicals that require a specific amino structure for further applications.
For instance, such specialty chemicals can be tailored for use in cosmetics, agricultural products, and
functional materials for industrial applications. The ability to efficiently convert Bz-NGT-NH2 to these
end products is highly valued in creating compounds with specific properties such as improved stability,
enhanced efficacy, or specific interactive attributes, thus expanding its range of uses across different
industries.
Overall, the role of Bz-NGT-NH2 in both intermediate synthesis and broader research
applications underlines its importance in modern chemical industries. Its utility serves not only
immediate production needs but also longer-term developments in science and technology, highlighting its
contribution as a flexible and vital compound in various innovative processes.
How does
Bz-NGT-NH2 contribute to the pharmaceutical industry?
Bz-NGT-NH2 contributes to the pharmaceutical
industry primarily through its function as a critical intermediate in the synthesis of active
pharmaceutical ingredients (APIs). Its structural composition allows it to be a versatile building
block, enabling the development of complex therapeutic drugs. The pharmaceutical industry values
compounds like Bz-NGT-NH2 because they serve as foundational materials whose chemical properties can be
exploited to create a wide range of drug candidates with various pharmacological activities.
One
of the significant contributions of Bz-NGT-NH2 is its involvement in the research and development phase
of pharmaceuticals. It facilitates the formation of new drug molecules by enabling modifications that
are crucial to optimizing biological activity and minimizing potential side effects. The NH2 group found
in Bz-NGT-NH2 is particularly significant because it allows chemists to introduce diverse
functionalities into the molecule, thus enabling the synthesis of compounds tailored to interact with
specific biological targets. This functional versatility is essential in the drug-design process, as
pharmaceutical scientists aim to enhance drug efficacy, target selectivity, and pharmacokinetic
profiles.
Moreover, Bz-NGT-NH2 plays an instrumental role in lead optimization stages. Here,
chemists utilize the compound to develop analogs with improved potency and safety profiles by exploring
various structural changes. This exploration and systematic alteration of the molecular structure of
Bz-NGT-NH2-based compounds can lead to the discovery of new drugs that address unmet medical needs, from
common ailments to complex and/or rare diseases.
The pharmaceutical industry also benefits from
Bz-NGT-NH2's contribution to scaling up production processes. As a stable and reliable intermediate, it
simplifies the transition from laboratory-scale synthesis to bulk manufacturing, ensuring consistency,
quality, and efficiency. Properly managed production processes involving Bz-NGT-NH2 help pharmaceutical
companies meet regulatory standards and streamline the pathway from drug discovery to market
availability.
Thus, the influence of Bz-NGT-NH2 is profound, playing a role not only in the
synthesis and development of new pharmaceuticals but also in the refinement of manufacturing processes
that deliver these medicines efficiently to the marketplace. It stands as a cornerstone compound in the
pharmaceutical industry's ongoing efforts to innovate and improve global health outcomes.
What
are the chemical properties and structure of Bz-NGT-NH2?
Understanding the chemical properties and
structure of Bz-NGT-NH2 is crucial for appreciating its versatility and broad range of applications.
Chemically speaking, Bz-NGT-NH2 is characterized by the presence of a primary amine group (NH2) attached
to a benzoylated structural moiety. The juxtaposition of these functional groups within the molecular
framework provides Bz-NGT-NH2 with unique reactivity properties that are valuable in synthetic
chemistry.
Structurally, Bz-NGT-NH2 is built around a backbone that permits easy incorporation of
various functional groups through amide bond formation or acylation reactions. This structural
composition allows Bz-NGT-NH2 to act as a crucial intermediate in the formation of peptides and
proteins, which are often synthesized by linking amino acids in specific sequences. In terms of
molecular weight, the size and complexity of the Bz-NGT-NH2 molecule can influence its solubility in
different solvents, its thermal stability, and its chemical reactivity, each of which can be tuned
during synthesis depending on desired end uses.
The primary amine group (NH2) is a pivotal
feature of Bz-NGT-NH2, as it provides the chemical functionality required for further derivatization.
This group participates actively in nucleophilic substitution reactions, forming the basis for
substitutions that lead to a wide variety of modified compounds. As such, the NH2 group is a key player
in enabling the formation of chemically diverse structures through subsequent reaction mechanisms, such
as the formation of Schiff bases or reductive amination processes.
Additionally, the presence of
a benzoylated unit within Bz-NGT-NH2 imparts a degree of rigidity to the molecule, influencing its
interaction with other molecules and substrates. The aromatic nature of the benzoyl group plays a role
in π-stacking interactions – these non-covalent interactions influence molecular conformations, which
can be beneficial in the rational design of drug molecules. The aromaticity also contributes to defining
the electronic properties of Bz-NGT-NH2, allowing for interesting applications in electronics or
materials science where specific electrochemical properties may be required.
In summary, the
chemical properties and structure of Bz-NGT-NH2 make it an exceptionally versatile compound ready for
utilization in various chemical transformations. Its utility spans the spectrum from pharmaceutical
synthesis to material science, rooted in its fundamental structural and reactive characteristics,
allowing scientists across these fields to push the boundaries of innovation and discovery.
How
does Bz-NGT-NH2 compare to similar compounds in terms of efficacy and versatility?
When evaluating
Bz-NGT-NH2 in comparison to similar compounds, several factors come into play, particularly its efficacy
and versatility as a synthetic intermediate and its broad potential in various applications. Bz-NGT-NH2
is often favored over similar compounds because of its unique combination of structural and functional
attributes that contribute to its widespread use across different scientific and industrial
domains.
In terms of efficacy, Bz-NGT-NH2 stands out primarily because of the reactivity afforded
by its primary amine group in conjunction with a benzoyl moiety. This distinct combination enables
Bz-NGT-NH2 to participate in a wide range of chemical reactions, from forming simple amide linkages to
more complex multi-step synthetic pathways. Compared to similar amino compounds, Bz-NGT-NH2 often
provides a more stable intermediate, allowing for better control and predictability during synthesis.
Its reactivity can often translate directly into higher yields and more efficient synthesization
processes, which is a critical consideration in both research and industrial
production.
Regarding versatility, Bz-NGT-NH2's structural properties permit wide-ranging
applications, a trait not always shared by similar compound classes. Its capacity to serve as a
precursor in pharmaceutical development is vastly superior given its adaptability to produce different
pharmacophores. These pharmacophoric features can then target specific biological pathways or molecular
targets, broadening the potential for novel therapeutic developments. Similarly, its applicability is
not limited to the pharmaceutical arena alone; Bz-NGT-NH2 can be leveraged in creating specialty
chemicals and new materials for various industries, from agriculture to electronics, making it
significantly more versatile than compounds with less flexibility.
Moreover, in comparison with
other similar molecules that may only provide straightforward pathways, Bz-NGT-NH2's diverse reaction
possibilities enable it to act as a chameleon in the lab setting. These characteristics push it to the
forefront of selection when multifaceted synthetic strategies are in demand. In comparison, other
compounds may have limited engagement in specialized reactions, thus narrowing their usefulness in
comprehensive and innovative chemical processes which demand a high degree of versatility and
specificity.
Ultimately, while other similar compounds might offer certain distinctive advantages
depending on context or intended use, Bz-NGT-NH2’s strengths lie in its multifaceted efficacy as a
reagent and unparalleled versatility in diverse scientific, pharmaceutical, and industrial applications.
This makes it an indispensable compound whose broad applicability can be strategically leveraged for
advancement in both aimed research and practical production processes.
What are the primary
safety considerations when handling Bz-NGT-NH2 in a laboratory environment?
Handling Bz-NGT-NH2 in a
laboratory setting involves several key safety considerations that must be thoroughly understood and
implemented to ensure safe working conditions. As with any chemical compound, particularly those used in
research or industrial applications, understanding the physical and chemical properties of Bz-NGT-NH2 is
fundamental to mitigating potential hazards that may arise.
To begin with, safety data sheets
(SDS) specific to Bz-NGT-NH2 must be consulted before use. These documents provide essential information
on handling, storage, and disposal procedures while also outlining potential hazards. Safety measures
typically include wearing appropriate personal protective equipment (PPE) such as lab coats, gloves, and
eye protection to prevent direct contact with the compound. Depending on the level of exposure,
additional PPE such as respirators or face shields might be necessary if there is a risk of inhalation
or exposure to aerosols.
Chemical exposure can pose significant risks, such as respiratory
irritation, skin sensitization, or more severe health issues depending on the level and duration of
exposure. Thus, maintaining good laboratory hygiene practices is paramount. The workspace should be
well-ventilated, ideally with an appropriate chemical fume hood, to minimize inhalation risks. Moreover,
standardized chemical waste disposal procedures should be strictly followed to avoid environmental
contamination or unintended chemical reactions.
Another critical aspect is understanding the
reactivity profile of Bz-NGT-NH2. You need to be aware of its potential reactions with other chemicals
to prevent unintended reactions, such as exothermic releases or the evolution of harmful gases. Careful
planning of experiments includes verifying chemical compatibility with all materials and reagents in
use.
Training for laboratory personnel is also critical. Well-trained staff are aware of
emergency procedures, including spill management, exposure response, and evacuation plans in the event
of an incident. Training also emphasizes the proper use and maintenance of safety equipment, such as
fire extinguishers, eyewash stations, and emergency showers, which are crucial components of laboratory
preparedness.
Finally, regular safety audits and risk assessments are effective measures to
identify potential hazards arising from changes in procedures or the introduction of new compounds into
the laboratory environment. These assessments help to ensure compliance with safety regulations and
promote an ongoing culture of safety, minimizing the risk of accidents related to the handling of
Bz-NGT-NH2 or any similar compounds.
By adhering to these primary safety considerations and
making use of available resources and training, the risks associated with handling Bz-NGT-NH2 in a
laboratory can be effectively managed, ensuring a safe environment for both researchers and the broader
community.