Synonym |
CALP-3 |
Species |
Human |
Protein Accession |
P08493 |
Purity |
Greater than 95% |
Endotoxin Level |
Less than 1 EU/μg |
Biological Activity |
Not specified |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
18.3 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS |
Reconstitution |
It is recommended to reconstitute the lyophilized CALP-3 in sterile 18 MΩ-cm H2O not less than
100 µg/mL, which can then be further diluted to other aqueous solutions. |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated
freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of
time. |
FAQ
What is Calcium-Like Peptide 3, CALP-3, and how does it work in the body?
Calcium-Like Peptide 3,
CALP-3, is a specially formulated peptide designed to mimic the action of calcium within the body. The
peptide works by interacting with calcium-binding proteins, which play crucial roles in various
physiological processes including muscle contraction, nerve transmission, bone stability, and cellular
signaling. Through its calcium-mimicking activity, CALP-3 enhances cellular functions by stabilizing the
interactions of these proteins, thereby facilitating essential physiological processes. It is engineered
to support bone density, improve muscle flexibility, and promote optimal cellular health by ensuring
that the body maintains appropriate levels of calcium activity.
Within the body, CALP-3 emulates
calcium’s role in the calcium-signaling pathway, vital for intracellular communication. By binding to
calcium receptors, it stabilizes calcium levels, even in the absence of high dietary calcium intake.
Additionally, CALP-3's design means it can be absorbed and utilized efficiently, avoiding the pitfalls
often associated with calcium supplements, such as poor absorption or gastrointestinal discomfort. The
peptide's interaction with calcium transporters additionally suggests potential benefits for cellular
hydration, nutrient uptake, and neurotransmission systems, playing a critical part in cognitive health
and energy metabolism.
Traditionally, calcium supplements have been used to correct calcium
deficiencies and support bone health, but they often carry the risk of complications, such as kidney
stones or cardiovascular issues due to excessive calcium buildup. CALP-3 offers a safer alternative by
directly influencing and optimizing calcium activity at the cellular level without the need for high
dosages. This makes it particularly advantageous for individuals who may have dietary restrictions or
factors inhibiting traditional calcium supplement absorption.
What are the potential health
benefits of taking CALP-3?
Calcium-Like Peptide 3 offers a broad spectrum of potential health
benefits. One of the primary benefits is its ability to support bone density and strength. By mimicking
calcium and engaging with calcium-binding proteins within bones, CALP-3 helps in maintaining and
potentially improving bone mineralization without the risks often associated with high-dosage calcium
supplementation. This aspect is particularly beneficial for older adults or post-menopausal women who
are at increased risk for osteoporosis, providing them a safer and potentially more effective
alternative to traditional calcemic interventions.
Moreover, CALP-3 supports muscle contractions
and may enhance muscle functionality. Calcium ions play an integral part in muscle contraction cycles by
enabling the interaction of actin and myosin, the proteins responsible for muscle movement. By
regulating calcium ion activity within the muscle cells, CALP-3 promotes optimal muscle functionality,
which may aid in athletic performance, endurance, and recovery. This could be highly beneficial for
individuals engaging in regular physical activity or those recovering from muscle-related
injuries.
Furthermore, CALP-3 is thought to positively impact cardiovascular health. Proper
calcium signaling is crucial for the contraction and relaxation of cardiac muscles and the regulation of
blood vessel diameter. By stabilizing these processes, CALP-3 may help in maintaining optimal blood
pressure levels and supporting overall heart health. This peptide also potentially supports cognitive
functions due to its role in neurotransmitter release, which require precise calcium ion fluxes. By
supporting calcium regulation, CALP-3 might enhance cognitive functions like memory, learning, and
concentration.
Additionally, CALP-3’s influence extends to metabolic activities, potentially
aiding in insulin regulation and glucose metabolism. This can be particularly beneficial for individuals
striving to manage blood sugar levels effectively. Lastly, the peptide’s potential for improved nutrient
absorption and increased cellular permeability optimizes nutrient uptake and cellular hydration, thereby
supporting an overall enhanced state of well-being.
How is CALP-3 different from traditional
calcium supplements?
Calcium-Like Peptide 3 differentiates itself from traditional calcium
supplements primarily through its mechanism of action and its targeted efficacy. Traditional calcium
supplements typically work by increasing the overall calcium levels in the body through oral intake,
which then get absorbed and utilized by the body as needed. This often involves high dosages because
there is a significant variance in absorption efficacy among individuals. On the other hand, CALP-3
operates by mimicking the functional properties of calcium at a cellular level, directly targeting
calcium receptors and binding proteins. This targeted approach allows for more efficient and effective
calcium-like activity without the necessity of high dosages.
One of the main problems with
traditional calcium supplements is bioavailability, meaning the proportion of calcium that is actually
absorbed into the bloodstream. Several factors, such as age, dietary habits, and gastrointestinal
health, can affect this process. High dosages of calcium are often required to account for poor
absorption rates, which can lead to potential issues such as the formation of kidney stones or
cardiovascular problems due to calcification in arteries and soft tissues. CALP-3 circumvents these
challenges by not merely increasing calcium presence but enhancing its specific signaling actions and
interactions within the body, reducing the need for high intake volumes.
Furthermore, traditional
calcium supplements do not take the bioactivity or efficiency of utilization into account. They do not
actively engage with the biological pathways necessary for calcium's roles in cellular signaling, muscle
contraction, or neurotransmitter release. CALP-3 actively participates in these processes by stabilizing
calcium signaling pathways which can be beneficial in not just maintaining bone health, but also in
contributing to muscle function, neural transmission, and metabolic processes. CALP-3 is designed for a
more holistic enhancement of health, potentially offering benefits that go beyond what traditional
calcium supplements are capable of, especially in areas related to cellular function and systemic
regulation.
Who should consider using CALP-3?
CALP-3 is suitable for a diverse range of
individuals seeking to optimize their calcium-related physiological processes without the drawbacks of
traditional calcium supplementation. It is particularly beneficial for older adults who are more
susceptible to bone density loss and conditions like osteoporosis. Unlike high-dose calcium supplements
that provide a blanket increase in calcium intake, CALP-3 offers targeted support by engaging with
bone-maintaining processes, thus providing a safer and potentially more effective approach to sustaining
bone health as one ages.
Active individuals and athletes also stand to benefit from CALP-3, given
its role in muscle function and recovery. Calcium ions are crucial for muscle contractions, and CALP-3’s
ability to stabilize these processes can lead to improved performance and a more efficient recovery
phase post-exercise. This makes the peptide an appealing option for athletes or anyone engaged in
regular physical training keen on optimizing their muscular efficiency and reducing downtime due to
muscle strain or injury.
Furthermore, individuals with dietary restrictions or gastrointestinal
issues that inhibit the absorption of traditional calcium supplements could find CALP-3 advantageous.
Because CALP-3 affects calcium signaling directly and does not require the absorption of large volumes
of calcium, it provides a promising alternative for those individuals who have issues with calcium
metabolism or who follow diets that might limit their calcium intake. This could include people on vegan
diets or those with lactose intolerance, who sometimes struggle to meet their daily calcium requirements
through diet alone.
Moreover, those interested in maintaining cardiovascular health or dealing
with blood pressure management may explore CALP-3’s benefits as calcium plays a direct role in
cardiovascular function, influencing heart and blood vessel contractility. Lastly, individuals aiming to
improve cognitive functions and metabolic processes could consider CALP-3, seeing as calcium signaling
is foundational to neurotransmitter activity and metabolic regulation.
Are there any potential
side effects associated with CALP-3?
As with any supplement, understanding potential side effects
is crucial for making informed health decisions. CALP-3, due to its novel mechanism of action, offers a
profile that is generally considered to be well-tolerated by most users. By mimicking calcium activity
rather than simply adding to total calcium intake, CALP-3 significantly minimizes the risk of common
side effects associated with traditional calcium supplements. Typical side effects from high calcium
intake include gastrointestinal discomfort, such as bloating and constipation, as well as more severe
issues like kidney stones and the potential for cardiovascular problems due to vascular calcification.
These side effects are largely linked to the body's inability to handle excess calcium
effectively.
CALP-3, however, operates at a cellular level, promoting better calcium signaling
rather than sheer volume. This specific targeting reduces the likelihood of gastrointestinal irritation
as it doesn't accumulate within the digestive system like traditional forms of calcium. Additionally,
since it does not contribute to excess calcium in the bloodstream, CALP-3 does not carry the same risk
of leading to kidney stone formation or cardiovascular calcification. Its nature minimizes the risk of
calcium imbalances within the body, offering a complete advantage over conventional supplementation
methods.
Nonetheless, it is essential to consider individual biological variability. As with all
supplements, immune or hypersensitivity reactions, although rare, can occur. Potential reactions are
commonly related to inactive ingredients or individual allergies. It is always advised that people with
known allergies or sensitivities to ingredients used in peptide formulations discuss with healthcare
providers prior to initiating any supplementation. Additionally, individuals with specific chronic
conditions or those currently on medications should consult with healthcare professionals to ensure
there are no potential interactions.
While CALP-3 is formulated to minimize adverse effects,
careful adherence to recommended use in discussion with healthcare professionals will provide the best
approach to incorporating this peptide into any health regimen safely, optimizing its benefits while
minimizing any adverse outcomes. For personalized advice on supplement use and possible interactions
with existing health profiles, consulting with healthcare providers remains the cornerstone of safe
supplement use.