Synonym |
Carcinine |
Species |
Human |
Protein Accession |
P12345 |
Purity |
Greater than 95% |
Endotoxin Level |
Less than 1 EU/μg |
Biological Activity |
Not specified |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
15 kDa |
Formulation |
Lyophilized |
Reconstitution |
Reconstitute in PBS |
Storage & Stability |
Store at -20°C upon receipt, aliquot and store at -20°C or -80°C |
FAQ
What is Carcinine and how does it benefit my skin?
Carcinine, also known as N-acetyl
homocarnosine, is a naturally occurring compound that has garnered attention in recent times due to its
impressive benefits for skin health. As an antioxidant, Carcinine plays a critical role in protecting
the skin from oxidative stress, which is one of the primary causes of aging and skin damage. Oxidative
stress occurs when there is an imbalance between free radicals and antioxidants in the body. Free
radicals are unstable molecules that can cause damage to cells, leading to premature aging, wrinkles,
and various skin maladies. By neutralizing these free radicals, Carcinine helps to maintain the
integrity and beauty of the skin.
One of the major benefits of Carcinine is its ability to
enhance the skin's resilience against environmental aggressors, such as UV radiation from the sun,
pollution, and even harsh weather conditions. These environmental factors can lead to the formation of
reactive oxygen species that further exacerbate skin damage. Carcinine’s potential comes into play by
providing a robust defense mechanism that helps to shield the skin from these harmful agents, ultimately
slowing down the extrinsic aging process.
Moreover, Carcinine's role in skin hydration should not
be overlooked. It has been shown to improve the moisture retention capabilities of the skin, which is
crucial for maintaining a plump and youthful complexion. Proper hydration is essential for the skin's
barrier function, which protects against irritants and prevents water loss. By supporting hydration,
Carcinine helps to keep the skin smooth, supple, and less prone to dryness and flakiness.
In
addition to these benefits, Carcinine also exhibits anti-glycation properties. Glycation is a process
where sugar molecules bond with proteins or lipids, resulting in the formation of advanced glycation
end-products (AGEs). These AGEs can lead to the deterioration of collagen and elastin, two proteins that
are vital for maintaining skin elasticity and firmness. By inhibiting glycation, Carcinine helps to
preserve these structural proteins, thereby enhancing the skin's ability to remain firm and elastic as
people age.
Furthermore, Carcinine's anti-inflammatory properties can be particularly beneficial
for individuals who have sensitive skin or suffer from conditions such as rosacea, eczema, or acne. By
reducing inflammation, Carcinine can help to alleviate redness, swelling, and discomfort, promoting a
more even skin tone and smoother texture.
Overall, Carcinine offers a plethora of benefits for
the skin by functioning as a powerful antioxidant, providing protection against environmental damage,
enhancing hydration, preventing glycation, and reducing inflammation. Its comprehensive approach to skin
health makes it an attractive component in skincare formulations aimed at promoting a youthful and
vibrant complexion.
How does Carcinine act as a powerful antioxidant in
skincare?
Carcinine's reputation as a potent antioxidant is well-deserved, owing to its ability
to combat oxidative stress effectively, which is a major contributing factor to skin aging and cellular
damage. At the molecular level, Carcinine possesses unique properties that enable it to neutralize free
radicals — unstable molecules generated by factors such as UV light, pollution, stress, and even normal
metabolic processes. These free radicals, if left unchecked, can lead to a cascade of cellular damage
that accelerates aging, resulting in wrinkles, fine lines, and a loss of skin elasticity.
The key
to Carcinine's antioxidant capacity lies in its chemical structure. It is a naturally occurring
dipeptide that can penetrate the skin's surface to reach the deeper layers where oxidative stress often
causes the most harm. Once inside, Carcinine effectively scavenges reactive oxygen species, thereby
preventing these radicals from damaging cellular components like DNA, proteins, and lipids. This action
not only protects skin cells but also preserves the skin's overall health and
appearance.
Additionally, Carcinine's antioxidant properties are enhanced by its stability.
Unlike some antioxidants that degrade rapidly when exposed to oxygen or light, Carcinine remains stable,
which ensures that it continues to provide protective benefits over time. This prolonged activity is
particularly valuable because it means Carcinine offers lasting defense against oxidative damage,
contributing to a sustained improvement in skin appearance and texture.
Further emphasizing its
role as an antioxidant, Carcinine aids in the regeneration of other antioxidants within the skin. It can
work synergistically with other compounds like vitamin C and vitamin E, which are also important
antioxidants. By supporting their regenerative cycles, Carcinine enhances the overall antioxidative
shield of the skin, making the combined effect even more potent. This helps to create a more resilient
dermal environment that can withstand environmental challenges more effectively.
Importantly,
Carcinine's ability to function as an antioxidant without causing irritation makes it suitable for use
across various skin types, including sensitive skin. Many individuals with sensitive skin may avoid
certain antioxidant ingredients due to potential irritation or allergic reactions, but Carcinine's
gentle nature allows for its inclusion in their skincare routine, providing all the antioxidative
benefits without unwanted side effects.
Overall, Carcinine’s role as a powerful antioxidant lies
in its ability to neutralize free radicals effectively, its chemical stability, and its ability to work
collaboratively with other antioxidants. These properties make Carcinine an excellent choice for those
looking to fortify their skin against the damaging effects of oxidative stress while promoting a
healthy, youthful complexion.
Can Carcinine help with skin hydration and how?
One of the
often highlighted features of Carcinine is its ability to significantly contribute to skin hydration, an
essential component of maintaining healthy, radiant skin. Proper hydration is crucial for maintaining
the skin barrier's integrity, which serves as the primary defense against environmental pollutants,
bacteria, and other potential irritants. Without sufficient moisture, the skin can become dry, flaky,
and more susceptible to damage, leading to a compromised appearance and a host of skin
concerns.
Carcinine promotes skin hydration through several mechanisms, each of which works to
ensure that the skin retains moisture effectively. Firstly, it enhances the skin’s natural moisture
retention abilities by strengthening the skin barrier. The skin barrier's primary function is to
maintain the balance of water within the skin, preventing excessive water loss and keeping the skin
hydrated. Carcinine aids in reinforcing this barrier, thereby ensuring that moisture is retained and
dehydration is minimized. By supporting the integrity of the skin barrier, Carcinine ensures that the
skin stays supple and resilient against external aggressors.
Another way Carcinine aids in skin
hydration is through its anti-glycation properties. Glycation, as previously mentioned, involves the
binding of sugar to proteins or lipids, which can damage the skin's collagen and elastin fibers.
Collagen and elastin are integral components that not only provide structural support to the skin but
also play a pivotal role in retaining moisture. When these proteins are damaged, the skin's ability to
hold onto water decreases. By inhibiting glycation, Carcinine helps preserve the function and structure
of these proteins, allowing the skin to maintain its elasticity and moisture content.
In tandem
with these benefits, Carcinine’s action against oxidative stress indirectly promotes skin hydration.
Oxidative stress can lead to cell damage, influencing the skin's capacity to conserve moisture. By
neutralizing free radicals and reducing oxidative stress, Carcinine helps maintain cellular health,
ensuring that skin cells function optimally in regulating hydration levels.
Moreover, Carcinine
fosters a microenvironment conducive to the skin’s natural moisturizing factors (NMFs). The NMFs are
crucial components of the outer skin layer that help in attracting and retaining water. By creating a
favorable condition for NMFs to thrive, Carcinine ensures that the natural humectants in the skin work
at their best potential.
In conclusion, Carcinine helps with skin hydration by reinforcing the
skin barrier, preserving collagen and elastin from glycation, reducing oxidative stress, and optimizing
conditions for natural moisturizing factors. Its comprehensive approach ensures that the skin remains
well-hydrated and resilient, an essential factor for maintaining a youthful and vibrant
appearance.
What role does Carcinine play in combating signs of aging?
Carcinine plays a
substantial role in combating the signs of aging due to its multifaceted properties, primarily rooted in
its antioxidant, anti-glycation, and anti-inflammatory activities. Aging is a natural process
characterized by a gradual decline in the skin's structural integrity and function, often manifested in
the form of wrinkles, fine lines, age spots, and loss of elasticity. Several intrinsic and extrinsic
factors, such as genetic predisposition, environmental damage, and lifestyle choices, can exacerbate
these visible signs of aging.
One of the primary roles of Carcinine in addressing aging is its
antioxidant capability. By neutralizing free radicals, which are one of the main contributors to
premature skin aging, Carcinine helps protect skin cells from oxidative damage. Free radicals cause a
breakdown of cellular components, including collagen and elastin, which are crucial for maintaining skin
firmness and elasticity. By safeguarding these macromolecules from oxidative stress, Carcinine supports
the structural integrity of the skin, thereby minimizing the appearance of fine lines and
wrinkles.
Carcinine's anti-glycation property further emphasizes its role in combating aging.
Glycation is a physiological process where excess sugar molecules bind to proteins, including collagen
and elastin, leading to the formation of advanced glycation end-products (AGEs). AGEs can stiffen and
degrade these proteins, compromising the skin’s firmness and elasticity and leading to sagging and the
formation of wrinkles. By inhibiting glycation, Carcinine preserves the functionality of collagen and
elastin, thereby promoting a more youthful skin appearance.
In addition to these, Carcinine
exhibits anti-inflammatory properties which are crucial in addressing age-related changes in the skin.
Chronic inflammation, often called "inflammaging," can lead to accelerated aging. It promotes the
breakdown of essential skin components and impairs repair mechanisms, contributing to an increase in
visible signs of aging. By mitigating inflammation, Carcinine helps in reducing redness, swelling, and
irritation, nurturing a calmer and more even-toned complexion.
Furthermore, Carcinine's role
extends to skin hydration, which is intimately tied to youthful skin. As skin ages, its ability to
retain moisture decreases, leading to dryness and an increased prominence of fine lines. Carcinine
supports the retention of moisture by aiding in the maintenance of a healthy skin barrier and optimizing
natural moisturizing factors, keeping the skin plump and hydrated, which is crucial for minimizing the
appearance of aging signs.
Lastly, Carcinine's effectiveness is amplified when used in synergy
with other anti-aging ingredients, such as retinoids, peptides, and co-antioxidants like vitamins C and
E. These combinations can help enhance collagen production, improve skin elasticity, and provide
comprehensive protection against multiple aging pathways.
Overall, Carcinine combats signs of
aging through its antioxidant, anti-glycation, anti-inflammatory, and moisturizing properties, making it
a valuable component in skincare aimed at preserving a youthful appearance and delaying the onset of
age-related changes of the skin.
How does Carcinine help in reducing inflammation in the
skin?
Carcinine's role in reducing inflammation is significant, offering a boon to individuals
dealing with inflammatory skin conditions such as acne, eczema, rosacea, and general skin sensitivity.
Inflammation is a biological response to harmful stimuli, including pathogens, damaged cells, and
irritants, and can present as redness, swelling, heat, and pain on the skin. While acute inflammation is
a protective mechanism intended to heal damage, chronic inflammation can harm the skin, leading to
accelerated aging, impaired barrier function, and a host of dermatological issues.
One of the
primary ways Carcinine helps reduce inflammation is through its inherent anti-inflammatory properties,
which act by modulating the body's inflammatory response. This modulation involves hindering the
pathways that lead to an overproduction of inflammatory mediators like cytokines and prostaglandins.
These substances, when produced excessively, contribute to persistent inflammation, resulting in various
skin concerns. By inhibiting these mediators, Carcinine helps in diminishing the redness, swelling, and
discomfort associated with inflammation.
Additionally, Carcinine's antioxidative capabilities
indirectly aid in managing inflammation. Oxidative stress can exacerbate inflammatory responses by
damaging skin cells and triggering pathways that further promote inflammation. By neutralizing oxidative
stress, Carcinine helps limit further inflammatory reactions, thereby providing relief from excessive
inflammation and its impact on the skin.
Carcinine also supports the skin’s natural repair
mechanisms, which can become compromised during chronic inflammation. It contributes to healing by
ensuring that skin cells maintain their structural integrity and can regenerate effectively, helping to
close minor wounds or lesions more efficiently. This reparative support not only improves the skin's
resilience but also minimizes the potential for scarring, a common consequence of prolonged
inflammation.
In relation to specific skin conditions, Carcinine's anti-inflammatory effects can
be particularly beneficial for acne-prone individuals. Acne inflammation, caused by clogged pores and
bacterial infection, often leads to painful pimples and potential scarring. Carcinine, by reducing the
inflammatory response, helps to minimize the size and redness of acne lesions, promoting clearer skin
over time.
Moreover, for those with eczema or rosacea, conditions characterized by heightened
skin sensitivity and inflammation, Carcinine offers a soothing effect. It can help calm the skin,
reducing episodes of flare-ups and providing a more even skin tone. This is particularly advantageous
for maintaining stable and manageable skincare conditions in the long term.
Furthermore,
Carcinine’s ability to work synergistically with moisturizing agents enhances its anti-inflammatory
effectiveness. Well-hydrated skin is less prone to irritation and inflammation, and Carcinine’s moisture
retention support ensures that the skin barrier functions optimally, reducing trans-epidermal water loss
and irritant penetration.
In summary, Carcinine helps reduce inflammation through its direct
anti-inflammatory actions, antioxidative property, support of natural repair processes, and synergy with
hydration factors. Its comprehensive effect on inflammation alleviates discomfort and supports healthier
skin, making it especially suitable for sensitive and irritated skin types.