Synonym |
Cyclo(Asp-Gly) |
Species |
Human |
Protein Accession |
N/A |
Purity |
≥ 95% |
Endotoxin Level |
< 1.0 EU per 1 μg of protein |
Biological Activity |
N/A |
Expression System |
Chemical synthesis |
Fusion Tag |
N/A |
Predicted Molecular Mass |
263.2 Da |
Formulation |
Lyophilized |
Reconstitution |
Reconstitute in water to a concentration of 0.1-1.0 mg/ml |
Storage & Stability |
Store at -20°C upon receipt. Recommend to spin tubes briefly prior to opening. Store at -20°C.
For optimal storage, aliquot and store at -20°C or -80°C. |
FAQ
What is Cyclo(Asp-Gly) and how does it benefit my health?
Cyclo(Asp-Gly) is a cyclic dipeptide
made up of aspartic acid and glycine. These compounds, known as dipeptides, are essential to numerous
biological processes in the body and form the building blocks of proteins. When amino acids like
aspartic acid and glycine are bonded together to create a cyclic structure, their properties and effects
can be distinct from when they operate independently. This unique configuration of Cyclo(Asp-Gly) is
what contributes to its wide range of potential health benefits. One of the primary ways that
Cyclo(Asp-Gly) benefits health is by enhancing cellular functions. As part of metabolic processes, it
can play a critical role in signaling pathways that regulate various cellular activities. By improving
cellular communication and efficiency, Cyclo(Asp-Gly) aides in optimizing metabolism, which is vital for
maintaining energy balance and physiological stability. Additionally, when metabolism is functioning
optimally, it reflects in an improved basal metabolic rate, potentially assisting in weight management
and the prevention of metabolic syndromes like obesity and diabetes. Further, Cyclo(Asp-Gly) is linked
to cardiovascular health support. Aspartic acid, as one of its constituent elements, is known to have
roles in ammonia detoxification and regulation of nitric oxide, which is crucial for vasodilation.
Vasodilation refers to the widening of blood vessels, ensuring better blood flow and reducing blood
pressure levels. This property of vasodilation is crucial in preventing cardiovascular diseases, as it
helps to mitigate risks such as atherosclerosis or undue pressure on arterial walls. Therefore,
integrating Cyclo(Asp-Gly) into a health regimen may contribute significantly to heart health through
regulatory effects on cardiovascular function. Moreover, this dipeptide has promising benefits over
cognitive health. Glycine, a simple non-essential amino acid, is recognized for its neurotransmitter
activity in the brain. It acts as an inhibitory neurotransmitter, which means it can have calming
effects by diminishing neuronal excitability. This can help reduce stress and promote better mental
health outcomes, including enhanced mood and cognitive functions. As part of Cyclo(Asp-Gly), glycine
could potentially impact neurotransmission, thus contributing to maintaining a balanced mental state.
Not to forget, the role of glycine in sleep regulation is well-documented, and Cyclo(Asp-Gly) could,
therefore, have a potential part to play in improving sleep patterns. In conclusion, while
Cyclo(Asp-Gly) is relatively new in scientific exploration, its potential health benefits, owing to its
constituents, are wide-ranging and significant. It offers an intriguing natural option for supporting
various aspects of health, from cellular metabolism and cardiovascular health to cognitive and mental
well-being, making it a noteworthy consideration for those aiming for a holistic approach to health
management.
How is Cyclo(Asp-Gly) different from other amino acid
supplements?
Cyclo(Asp-Gly) distinguishes itself from traditional amino acid supplements in
several key aspects, primarily due to its cyclic structure and the unique interactions of its component
amino acids—aspartic acid and glycine. These distinctions are crucial as they underpin both its mode of
action and the range of potential health benefits it offers. One of the primary differences between
Cyclo(Asp-Gly) and conventional amino acid supplements is its structural configuration. Most amino acid
supplements contain linear chains of individual amino acids or simple peptide chains. Cyclo(Asp-Gly), on
the other hand, features a cyclic structure, which may enhance its stability and bioavailability. This
structural cyclicity often leads to more resilient molecular makeup, which can enhance its ability to
remain intact through digestive processes, delivering targeted effects as it is absorbed more
effectively than its linear counterparts. This increased stability and bioavailability can result in
enhanced efficacy in terms of how quickly and efficiently it reaches cellular targets and exerts
physiological effects. The presence of aspartic acid and glycine also sets Cyclo(Asp-Gly) apart.
Conventional amino acid supplements generally focus on delivering either essential amino acids or
specific amino acid blends like branched-chain amino acids (BCAAs) or peptides that target protein
synthesis specifically for muscle growth and recovery. Cyclo(Asp-Gly), with its aspartic acid component,
may benefit cardiovascular health by regulating ammonia detoxification and enhancing vasodilation,
presenting different physiological impacts when compared to the muscle-centric focus of BCAAs. Instead,
it helps in areas such as metabolism regulation and vascular health, providing a broader spectrum of
benefits. Glycine, another major component of Cyclo(Asp-Gly), is traditionally celebrated for its roles
in neurotransmitter function and neural regulation. In amino acid supplements, glycine might be
encountered either in free form or in simple combinations with other amino acids, but in Cyclo(Asp-Gly),
its action could be more pronounced given its cyclic combination with aspartic acid. This configuration
could allow glycine to more broadly display its cognitive-supportive and potentially its calming
properties, as suggested by its role as an inhibitory neurotransmitter. Therefore, Cyclo(Asp-Gly) could
have unique implications for mental well-being, unlike other amino acid supplements that may not
prioritize neurotransmitter regulation. Overall, Cyclo(Asp-Gly) offers potential health benefits that
span beyond the common expectations of amino acid supplements. Its potential impacts extend to
cardiovascular health, metabolism, and cognitive well-being, offering a multifaceted approach to health
that stands in contrast to the often singular focus of typical amino acid formulations.
What
potential applications does Cyclo(Asp-Gly) have in lifestyle and wellness?
Cyclo(Asp-Gly) holds
promise in a variety of lifestyle and wellness applications, owing to its unique properties that support
multiple bodily systems. This versatility makes it a compelling addition to personal health regimes
aimed at promoting overall wellness, enhancing physical performance, and improving mental health. One
potential application of Cyclo(Asp-Gly) is in the realm of sports and physical fitness. Aspartic acid,
one of the components in Cyclo(Asp-Gly), is known to play a significant role in the production and
release of hormones like testosterone and human growth hormone (HGH), both of which are vital for muscle
development, strength, and performance. Optimal levels of these hormones are integral for athletes and
fitness enthusiasts looking to enhance muscle size, power, and recovery. By potentially supporting these
hormonal functions, Cyclo(Asp-Gly) could help athletes optimize their training outcomes. Additionally,
the improvement in metabolism attributed to Cyclo(Asp-Gly) can result in better energy expenditure and
fat burning, allowing for improved body composition and weight management. By leveraging these metabolic
effects, those engaged in regular physical activity might improve both their endurance levels and
recovery rates, thus allowing for more intensive training and quicker recuperation of muscles
post-exercise. Beyond physical health benefits, Cyclo(Asp-Gly) may also cater to enhancing cognitive
functions, presenting another significant application in wellness. The glycine component of
Cyclo(Asp-Gly) acts as an inhibitory neurotransmitter in the brain, which can help in reducing anxiety,
enhancing mood stability, and improving cognitive functions like concentration and memory. In an era
where mental health is increasingly prioritized, the neuro-regulatory properties of Cyclo(Asp-Gly) make
it an attractive option for people wanting to tap into natural supplements for stress management, focus
enhancement, or overall cognitive well-being. Furthermore, these neurotransmitter-modulating properties
have implications for sleep quality. Sleep is a critical component of wellness, affecting everything
from mood and cognitive function to physical health and recovery. Glycine is often touted for its
natural sedative-like effects, promoting deeper and more restful sleep, which is critical for both
physical recovery and mental health. Incorporating Cyclo(Asp-Gly) into one’s lifestyle could therefore
support better sleep patterns, facilitating a well-rounded approach to wellness by ensuring restorative
rest. In conclusion, Cyclo(Asp-Gly) offers a diverse array of potential applications in lifestyle and
wellness that align with the varied requirements of those seeking a holistic approach to health. From
enhancing physical performance and supporting cognitive functions to promoting restful sleep and
metabolic health, this cyclic dipeptide allows individuals to target multiple dimensions of their
well-being, making it a multifaceted option within the wellness arena.
Can Cyclo(Asp-Gly) support
cognitive enhancement and mental well-being?
Cyclo(Asp-Gly) shows great potential as a compound
that can support cognitive enhancement and mental well-being, primarily due to the properties of
glycine, one of its core constituents. Glycine functions as an inhibitory neurotransmitter within the
central nervous system. Its ability to affect neural communication plays a significant role in
maintaining mental equilibrium. By tempering neuronal excitability, glycine can produce calming effects
on the brain, reducing instances of stress and anxiety. Cyclic configurations like Cyclo(Asp-Gly) may
enable glycine to exert these effects more efficiently, thanks to possibly enhanced stability and
bioavailability afforded by this unique structure. In terms of cognitive enhancement, the modulation of
neurotransmitter activity by Cyclo(Asp-Gly) could result in improved focus, memory, and cognitive
clarity. Glycine is known to facilitate better sleep quality by lowering core body temperature and
increasing the body's levels of serotonin, a precursor to melatonin—which regulates sleep-wake cycles.
Quality sleep is a cornerstone of cognitive health, enabling better mood, decision-making, and
neuroplasticity. When one's sleep patterns improve, the cognitive benefits are multifold, ranging from
improved recall and memory consolidation to enhanced mental energy and problem-solving capabilities.
Cyclo(Asp-Gly) might thus indirectly support these cognitive benefits by enhancing the sleep quality
necessary for mental rejuvenation. Mental well-being, on the other hand, gains support from
Cyclo(Asp-Gly) through its impact on mood regulation. Given that glycine is involved in the manufacture
of serotonin, it has a hand in mood stabilization. Elevated serotonin levels contribute to a sense of
well-being and happiness, and its regulation is pivotal in alleviating symptoms of depression and
anxiety disorders. Moreover, glycine has been associated with reducing schizophrenic symptoms due to its
role as a co-agonist at NMDA receptors, which are involved in synaptic plasticity and memory function.
Therefore, Cyclo(Asp-Gly) could present a potential therapeutic strategy in mental health care by
supporting neurotransmission balance. Alongside these scientific insights, there is a growing cultural
interest in nootropics and natural supplements for mental clarity and mood improvement. In such an
environment, Cyclo(Asp-Gly)'s neuro-regulatory characteristics place it as an interesting candidate for
those seeking non-pharmaceutical options for cognitive and emotional enhancement. Its dual benefits of
supporting both neurology and mental health propose a dual-action formula that might see increased use
among people prioritizing mental acuity and emotional health. In conclusion, Cyclo(Asp-Gly) certainly
holds promise in the domain of cognitive enhancement and mental well-being, not just through direct
neuro-impact from glycine, but also through the associated benefits of optimized sleep and mood
regulation. This positions it as a potent addition to mental wellness strategies, offering a
scientifically-backed approach to support a more balanced, focused, and positive mental
state.
How can Cyclo(Asp-Gly) aid weight management and metabolic health?
Cyclo(Asp-Gly)
can potentially aid weight management and improve metabolic health, making it a suitable supplement for
individuals seeking assistance in managing body weight and enhancing metabolic functions. This potential
largely arises from the benefits that stem from its constituent amino acids and their cooperation within
a cyclic structure. Aspartic acid, an amino acid component of Cyclo(Asp-Gly), contributes significantly
to the urea cycle, which is crucial in detoxifying ammonia—a byproduct of protein metabolism in the
body. By participating in this detoxification process, aspartic acid ensures that the metabolic pathways
remain efficient and uninterrupted, enabling better energy conversion, nutrient absorption, and overall
metabolic functionality. Enhancing the gut and liver's ability to handle ammonia boosts metabolic
efficiency, ensuring that more nutrients are streamlined towards energy production rather than storage
as fats. This aspect helps in maintaining an efficient metabolism conducive to weight management.
Moreover, aspartic acid has a potential role in enhancing hormone production, specifically hormones
involved in growth and energy regulation, such as testosterone. Elevated or regulated testosterone
levels can deter muscle loss, promote fat loss, and improve user overall body composition, thus
supporting weight management. A well-regulated testosterone level is moreover associated with improved
energy levels and dynamic metabolism, contributing to better commitment and efficacy in exercise—another
pillar of effective weight management. Glycine, the other amino acid forming Cyclo(Asp-Gly), represents
another pivotal component in metabolic health. Notably, glycine involvement in glucose regulation is
crucial as it aids in balancing blood sugar levels and increasing insulin sensitivity, both pivotal
measures in reducing diabetes risk and obesity-related challenges. By improving insulin sensitivity,
Glycine helps lower incidence rates of insulin resistance, a condition closely linked to obesity and
non-alcoholic fatty liver disease. Therefore, Cyclo(Asp-Gly) indirectly can contribute towards improving
metabolic parameters that favor effective weight management. Furthermore, since glycine also supports
the synthesis of glutathione—a powerful antioxidant—it assists in reducing oxidative stress and
inflammation, both of which are linked to metabolic syndrome and obesity. With reduced oxidative stress
and inflammation, the body can perform more resistance-free metabolic processes, essentially driving
better metabolic health outcomes. Additionally, improved mitochondrial function—as supported by these
antioxidants—translates to more efficient energy use, thus burning more calories and supporting weight
loss efforts. Besides these internal metabolic roles, Cyclo(Asp-Gly) can also have an auxiliary impact
on dietary habits via the mechanisms of glycine. The neurotransmitter action of glycine has implications
for mood regulation, and by facilitating emotional equilibrium, it might help curb stress-eating or
binge-eating episodes that contribute to weight gain. Conclusively, Cyclo(Asp-Gly) embraces various
pathways to aid weight management and metabolic health via its interactions with metabolic processes,
hormone regulation, and potential impacts on dietary patterns—all underlining its potential role as a
well-rounded agent in comprehensive weight management strategies.