Taiy Chemical
Cyclo(-Pro-Tyr)
Synonym Cyclo(Pro-Tyr)
Species Human
Protein Accession P01233
Purity ≥ 95%
Endotoxin Level < 1.0 EU per µg
Biological Activity The activity was determined by the inhibition of IL-8-induced IL-6 production in human peripheral blood mononuclear cells (PBMC) and is typically 1-5 ng/mL.
Expression System E. coli
Fusion Tag None
Predicted Molecular Mass 2449.8 Da
Formulation Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
Reconstitution Centrifuge vial before opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
Storage & Stability Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquot and store at -20°C for long-term storage.
FAQ
What is Cyclo(Pro-Tyr) and what are its primary benefits?

Cyclo(Pro-Tyr) is a cyclic dipeptide, composed of proline and tyrosine, which has gained interest in recent years due to its potential therapeutic benefits. As a dipeptide, it belongs to a class of organic compounds that are implicated in various physiological activities within the human body. Cyclo(Pro-Tyr) is particularly recognized for its role as a bioactive peptide with a unique structure that gives it stability and potency.

One of the primary benefits of Cyclo(Pro-Tyr) comes from its potential antioxidant properties. Antioxidants play a crucial role in combating oxidative stress, which is a major contributor to cellular damage and aging. By neutralizing free radicals, Cyclo(Pro-Tyr) can help protect cells from oxidative damage, thereby supporting overall cellular health. This makes it an interesting subject of study in anti-aging research and for conditions that are exacerbated by oxidative stress, such as certain neurodegenerative diseases.

Moreover, Cyclo(Pro-Tyr) exhibits potential anti-inflammatory properties. Inflammation is a natural process that, when chronic, can contribute to a host of disorders including arthritis, cardiovascular diseases, and metabolic syndromes. The anti-inflammatory effects of Cyclo(Pro-Tyr) could thus offer preventive as well as therapeutic benefits in managing such chronic conditions.

Another area where Cyclo(Pro-Tyr) shows promise is in immune modulation. A balanced immune response is essential for maintaining health and preventing autoimmune diseases and infections. Studies suggest that Cyclo(Pro-Tyr) might have the ability to modulate immune system activity, offering a potential benefit for individuals with compromised immune systems or those seeking enhanced immune support.

Additionally, Cyclo(Pro-Tyr) is explored for its neuroprotective benefits. Neuroprotection is critical in preventing neurodegenerative disorders, and preliminary research indicates that Cyclo(Pro-Tyr) may help protect neurons from damage, thereby supporting cognitive function and mental clarity.

Overall, Cyclo(Pro-Tyr) represents a promising area of research with potential benefits that extend to antioxidant, anti-inflammatory, immune, and neuroprotective domains. As scientific inquiry continues, it may offer new avenues for enhancing wellness and managing certain health conditions.

How does Cyclo(Pro-Tyr) interact with the human body?

Cyclo(Pro-Tyr) interacts with the human body in numerous intricate ways due to its biochemical composition and structure. As a cyclic dipeptide, it possesses a unique cyclic structure that makes it stable and resistant to enzymatic degradation, which enhances its bioavailability and allows it to be effective at relatively low concentrations. This structural stability enables Cyclo(Pro-Tyr) to retain its functional integrity as it circulates through the body.

One notable interaction of Cyclo(Pro-Tyr) in the body is its potential effect on cellular oxidative stress. It acts as an antioxidant, scavenging free radicals and reactive oxygen species that can cause cellular damage. By mitigating oxidative stress, Cyclo(Pro-Tyr) helps in maintaining the integrity of cell membranes and DNA, thus supporting overall cellular function and reducing the risk of age-related and degenerative diseases.

Cyclo(Pro-Tyr) also influences inflammatory pathways within the body. It is thought to interfere with the production and release of pro-inflammatory cytokines, thereby exerting an anti-inflammatory effect. This can help in reducing inflammation-induced tissue damage and offers potential therapeutic benefits in conditions where chronic inflammation is a core issue.

In addition, Cyclo(Pro-Tyr) may modulate the immune system's function. It's known to interact with immune cells, potentially enhancing the body's defense mechanisms against pathogens and reducing the risk of infections. This immune modulation is particularly significant in conditions where the immune response needs to be tightly regulated, such as in autoimmune disorders.

Neuroprotective interactions are another area of interest. Cyclo(Pro-Tyr) can cross the blood-brain barrier, a selective permeability barrier that protects the brain. Once in the central nervous system, it may provide protective effects against neurotoxic agents, support neuronal health, and contribute to cognitive enhancement. This interaction is crucial for exploring its potential in managing neurodegenerative disorders and supporting mental health.

Furthermore, there is speculation regarding Cyclo(Pro-Tyr)'s role in metabolic regulation. It may influence metabolism by modulating pathways involved in lipid and glucose metabolism. This interaction makes it a potentially valuable focus for research into metabolic disorders such as diabetes and obesity.

In summary, Cyclo(Pro-Tyr) interacts with the body by affecting oxidative stress, inflammation, immune modulation, neuroprotection, and potentially metabolism. These interactions provide a broad basis for its potential therapeutic applications and underline its significance in health-related research.

Are there any known side effects or risks associated with Cyclo(Pro-Tyr) use?

When considering the use of any bioactive compound, understanding potential side effects and risks is crucial. Cyclo(Pro-Tyr) has been studied for its positive health benefits, but all compounds may carry some risks, especially when not used appropriately. As with many emerging supplements or therapeutic agents, Cyclo(Pro-Tyr)'s complete safety profile is under ongoing exploration.

To date, Cyclo(Pro-Tyr) has shown a relatively low toxicity profile in preliminary studies, which is promising for its safety as a therapeutic agent. However, it is vital to approach these findings with caution. The potential side effects of Cyclo(Pro-Tyr) are not yet fully understood, largely due to a lack of extensive long-term human studies.

One concern associated with Cyclo(Pro-Tyr) could be its interaction with other substances. As with many bioactive compounds, Cyclo(Pro-Tyr) might interact with prescription medications, over-the-counter drugs, or other supplements, which could alter its effectiveness or cause unexpected side effects. It is always advisable to consult with healthcare professionals before starting any new supplement, including Cyclo(Pro-Tyr), especially for individuals who are on medication or have underlying health conditions.

Additionally, while Cyclo(Pro-Tyr) is generally considered safe due to its natural occurrence in biological systems, individual responses can vary. Some individuals might experience mild gastrointestinal discomfort, such as bloating or an upset stomach, especially if taken in higher doses. Sensitivities to dietary supplements can occur, and it is important to monitor one's body reaction when starting any new form of supplementation.

Another potential risk involves the purity and quality of Cyclo(Pro-Tyr) products available in the market. As with all dietary supplements, the source and quality of the product play a significant role in its safety profile. Products that are not properly manufactured or exceed recommended dosages can lead to adverse effects and reduce overall efficacy. Therefore, ensuring products are sourced from reputable manufacturers that follow good manufacturing practices is essential.

Finally, pregnant or nursing women, children, and individuals with specific health conditions should exercise extra caution and seek medical advice before using Cyclo(Pro-Tyr). While there is no specific data indicating harm to these groups, the lack of comprehensive studies necessitates a careful approach.

In conclusion, while Cyclo(Pro-Tyr) appears to be well-tolerated with a low risk of severe side effects, users should remain vigilant and informed. Consulting with healthcare professionals and choosing high-quality products can minimize potential risks and ensure safe use.

How can Cyclo(Pro-Tyr) contribute to anti-aging processes?

Cyclo(Pro-Tyr) is gaining attention in the anti-aging community, mainly due to its promising antioxidant and cellular protective properties. As the search for effective anti-aging interventions continues, Cyclo(Pro-Tyr) stands out due to its potential multi-faceted role in combating age-related changes at the cellular level.

One significant contribution Cyclo(Pro-Tyr) makes in anti-aging processes is through its antioxidant capabilities. Oxidative stress is a primary driver of aging as it leads to cellular damage by initiating the peroxidation of lipids, damage to DNA, and protein denaturation. Cyclo(Pro-Tyr) helps neutralize free radicals, thereby reducing oxidative damage to critical cellular components. This activity is crucial for maintaining cellular integrity and function, which is directly related to the aging process. By preventing or minimizing such damage, Cyclo(Pro-Tyr) may play a role in slowing down the visible and physiological signs of aging.

Another contribution is its potential to reduce chronic inflammation, which is another hallmark of aging often referred to as "inflammaging." Persistent low-grade inflammation is associated with age-related diseases, such as cardiovascular disorders, diabetes, and cancer. Cyclo(Pro-Tyr) may mitigate this through its anti-inflammatory properties, offering protection against inflammation-driven tissue damage and dysfunction, thereby promoting healthier aging.

Cyclo(Pro-Tyr) also supports metabolic functions which are known to decline with age, contributing to various metabolic disorders. By potentially modulating pathways involved in metabolism, Cyclo(Pro-Tyr) can help maintain metabolic balance, reducing the risk of conditions like insulin resistance and obesity. This modulation is vital because it not only affects longevity but also ensures quality of life in aging individuals.

Its role in neuroprotection is another significant aspect. Cognitive decline is a prominent age-related issue, with oxidative stress and inflammation being direct contributors. By offering neuroprotection, Cyclo(Pro-Tyr) might help preserve cognitive function, delay the onset of neurodegenerative conditions, and improve overall brain health, which is an integral part of the anti-aging process.

Furthermore, the potential of Cyclo(Pro-Tyr) to modulate immune response can contribute to maintaining a robust immune system, which naturally declines with age. An effective immune system is pivotal in protecting against infections and diseases, which can be more challenging to manage in older adults.

In summary, Cyclo(Pro-Tyr) contributes to anti-aging processes through its antioxidant capacity, anti-inflammatory action, support for metabolic processes, neuroprotective effects, and immune modulation. These multifaceted approaches at combating cellular and physiological aspects of aging underline its potential as a valuable component in anti-aging strategies.

Is Cyclo(Pro-Tyr) suitable for everyone?

While Cyclo(Pro-Tyr) shows great promise due to its potential health benefits, determining its suitability for everyone requires a nuanced understanding of individual health profiles and needs. The general consensus is that Cyclo(Pro-Tyr) offers benefits for many but should be tailored to individual cases, considering factors such as age, existing health conditions, interactions with medications, and overall lifestyle.

Cyclo(Pro-Tyr) might be suitable for adults seeking to enhance their antioxidant defenses, support anti-inflammatory responses, or bolster neuroprotection. Individuals who are interested in preventive approaches to aging and maintaining cognitive health could find it beneficial. However, as with any supplement, it is crucial to assess individual tolerance, especially because dietary supplements can sometimes induce idiosyncratic reactions in different people.

Special considerations should be given to particular groups. Pregnant and nursing women, for example, should exercise caution due to limited research on the effects of Cyclo(Pro-Tyr) during pregnancy and lactation. Similarly, those with pre-existing health conditions, especially related to the liver or kidney, or individuals with hormonal imbalances should consult healthcare professionals before considering its use. The effects of Cyclo(Pro-Tyr) on children or adolescents have not been extensively studied, hence its routine use in these populations is not recommended unless under medical advice.

For those on prescription medications, the suitability of Cyclo(Pro-Tyr) can greatly depend on drug interactions. Cyclo(Pro-Tyr) could interact with medications, altering their efficacy or leading to potential side effects. It is advisable to have a comprehensive medication review by a healthcare provider to ensure safe co-administration.

Moreover, individuals with allergies or sensitivities to supplements should also be cautious. Testing tolerance with small doses under professional guidance might be recommended to avoid any adverse reactions.

Lifestyle factors play an integral role in determining the suitability of Cyclo(Pro-Tyr). Individuals with extraordinarily stress-laden or physically demanding lives might benefit from its antioxidant or neuroprotective properties. Nonetheless, supplementation should complement other healthy lifestyle choices, including a balanced diet, regular physical activity, and stress management practices.

Thus, while Cyclo(Pro-Tyr) might be a suitable addition to many health and wellness regimes, its universal suitability cannot be assumed. A personalized approach, taking into account specific health needs and goals, alongside professional medical advice, is pivotal to determining its appropriateness for individual use.
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