Synonym |
Cyclo(Val-Val) |
Species |
Human |
Protein Accession |
N/A |
Purity |
Greater than 95% purity as determined by SDS-PAGE |
Endotoxin Level |
<1 EU per 1 µg of the protein |
Biological Activity |
Not specified |
Expression System |
Chemical synthesis |
Fusion Tag |
None |
Predicted Molecular Mass |
304.4 Da |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20% Acetonitrile and 0.1% TFA |
Reconstitution |
It is recommended to reconstitute the lyophilized Cyclo(Val-Val) in sterile 18 MΩ-cm H2O not
less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated
freeze-thaw cycles. Store at -20°C. For long-term storage, it is recommended to add a carrier
protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. |
FAQ
What is Cyclo(Val-Val) and how does it benefit athletes?
Cyclo(Val-Val) is a cyclic dipeptide or
diketopiperazine composed of two valine amino acids. Due to its unique structure, Cyclo(Val-Val) has
attracted significant attention in various fields, including sports science and nutrition. For athletes,
Cyclo(Val-Val) offers potential benefits due to its supposed roles in enhancing muscle metabolism,
supporting recovery processes, and providing antioxidant effects. These benefits can be particularly
important for athletes engaged in high-intensity training sessions or competitions. Due to its potential
role in muscle metabolism, Cyclo(Val-Val) might aid in more efficient energy utilization and possibly
improve performance during prolonged or intense physical activities. Athletes often experience oxidative
stress due to increased production of reactive oxygen species during intense exercise. Cyclo(Val-Val)
has been studied for its antioxidant-like properties, which could help neutralize these free radicals
and minimize damage during recovery, thus contributing to enhanced performance metrics. Recovery is a
crucial phase for athletes focusing on performance optimization, and this cyclic dipeptide may support
more efficient recovery by potentially reducing inflammation and muscle soreness post-exercise, enabling
athletes to maintain their workout intensity and frequency. While research into Cyclo(Val-Val) is
ongoing, current findings suggest that dietary incorporation might serve as a supplementary aid for
athletes. However, like any supplement, it should complement a well-rounded nutrition plan and a
dedicated training routine for optimal results, rather than being the primary driver of athletic
improvement.
Are there any side effects associated with Cyclo(Val-Val) supplementation for
athletes?
The safety profile of Cyclo(Val-Val) remains a significant area of exploration given
its growing curiosity in the sports nutrition domain. Current research indicates that it generally
exhibits a low toxicity level, making it ostensibly safe for human consumption, including athletes.
However, comprehensive clinical studies are relatively limited and mostly preliminary, which suggests
that while the existing data is optimistic, more robust, peer-reviewed studies are necessary to
establish a definitive safety profile for long-term use. Athletes considering integration of
Cyclo(Val-Val) into their regimen should exercise due diligence by staying abreast of emerging research
findings. Possible side effects could include gastrointestinal discomforts such as bloating, gas, or
nausea, particularly with higher dosages typical of many amino acid-based supplements. These side
effects are not unique to Cyclo(Val-Val) and are fairly common with dietary supplements, depending on
individual tolerance levels. Furthermore, considering that each athlete's biochemistry and dietary
requirements can vastly differ, consulting with a healthcare provider or a sports dietitian prior to
supplementation is advisable. Additionally, athletes should consider any potential interactions
Cyclo(Val-Val) might have with existing supplements or medications they are taking, to ensure
comprehensive safety. The well-being and health optimization of an athlete are paramount, and any
supplement introduced to assist performance or recovery should be considered with circumspection
alongside professional guidance. This approach complements current insights while aligning with best
practices of supplementation safety, emphasizing personalization and continuous research
evaluation.
How does Cyclo(Val-Val) contribute to muscle recovery post-exercise?
The role
of Cyclo(Val-Val) in muscle recovery post-exercise is anchored in its biochemical properties, presumed
to interact positively with muscle tissue undergoing repair and regeneration processes, as suggested by
preliminary studies. The recovery phase following exercise encompasses various physiological mechanisms,
including the repair of muscle fibers, rebalancing metabolic byproducts, and reducing
inflammation—processes that appear beneficently influenced by certain dipeptides like Cyclo(Val-Val). In
the context of muscle recovery, Cyclo(Val-Val)’s antioxidant potential is particularly relevant.
Physical exercise can ramp up oxidative stress, leading to free radical production that may inflict
minor muscular damage, thereby prolonging recovery periods. Due to its antioxidant effects,
Cyclo(Val-Val) might ameliorate oxidative stress impacts, facilitating a quicker return to an optimal
physiological state post-exercise, and inherently enhancing the recovery timeline for athletes.
Additionally, Cyclo(Val-Val) could aid in modulating inflammatory responses due to intensive workouts—a
common cause for muscular soreness known as delayed-onset muscle soreness (DOMS). In reducing the
inflammation associated with such conditions, Cyclo(Val-Val) holds potential in supporting a more
comfortable and efficient recovery phase. This could empower athletes to adhere to their training
schedules without compromising on intensity or duration due to lingering pain or soreness. It is
critical, however, for athletes to integrate such supplements as a part of a comprehensive recovery
strategy, which includes proper nutrition, hydration, rest, and stretching or physiotherapy regimens,
thereby optimizing the potential benefits Cyclo(Val-Val) might offer within the athlete's holistic
recovery framework.
Who can benefit from Cyclo(Val-Val) supplementation?
Cyclo(Val-Val)
may be beneficial for a diverse group of individuals, though most prominently for athletes and those
involved in regular, intense physical activities. The peptide’s potential to support muscle metabolism
and recovery makes it an attractive option not only for professional athletes but also for amateur
sports enthusiasts and fitness buffs aiming to optimize their performance and recovery processes. By
potentially enhancing muscle repair dynamics and recovery timelines, such individuals can see noticeable
advantages in their athletic pursuits or fitness training routine, which may foster improved performance
outcomes and decreased recovery time between sessions. Moreover, individuals who experience chronic
fatigue and muscle soreness due to other physical demands, such as labor-intensive occupations, or those
undergoing rehabilitation post-injury, could also find merit in exploring Cyclo(Val-Val) as a potential
enhancing agent. As with any dietary supplement, it's important for these groups to collaborate with
healthcare professionals for tailored ascertaining of need, safety, and appropriate dosing. Apart from
physically demanding scenarios, research into neuroprotective attributes of dipeptides, including
Cyclo(Val-Val), hints at prospective benefits extending beyond muscle-centric applications. While this
area demands more detailed investigation before concrete claims can be made, it highlights future
potential for this compound in supporting broader health aspects, potentially benefiting a wider
audience under professional guidance. Importantly, it should be emphasized that any use of
Cyclo(Val-Val) as a supplementation strategy should align with individual health goals, dietary
restrictions, or existing health conditions, reinforcing the importance of knowledgeable guidance,
comprehensive research understanding, and a personalized approach when considering Cyclo(Val-Val)
inclusion in a regimen.
Are there specific sports or activities where Cyclo(Val-Val)
supplementation is particularly effective?
Blessed with potential muscle metabolism and recovery
benefits, Cyclo(Val-Val) supplementation might offer significant advantages for specific sports or
activities characterized by high intensity, endurance, or frequent exertion. Among these, endurance
sports such as marathon running, cycling, and triathlons seem highly poised to benefit due to the
exhaustive nature of these activities and the resultant oxidative stress afflictions they impose on the
body. For endurance athletes, the primary concern often revolves around sustained energy levels and
rapid recovery transitions, which can potentially be ameliorated with the inclusion of antioxidant and
anti-inflammatory supports offered by compounds like Cyclo(Val-Val). Strength and resistance training
activities also present conducive opportunities for Cyclo(Val-Val) supplementation, predominantly due to
the pronounced muscle strain and resultant micro-tears these workouts tend to produce. In such
environments, faster recovery can enable athletes to maintain a higher frequency of training without
succumbing to excessive soreness or risking injury, thus supporting a more effective training cycle.
Similar merit could be observed in competitive team sports like soccer, basketball, or rugby, where
consistent performance across matches, tournaments, and training sessions necessitates rapid physical
restoration to meet ongoing team demands. Beyond these concentrated athletic contexts, individual
pursuits emphasized on fitness training or recreational activities striving for health enhancements
might also draw benefits from Cyclo(Val-Val)’s integration into training nutrition protocols.
Cyclo(Val-Val)’s potential contributions, particularly surrounding post-exercise recovery, antioxidant
support, and muscle metabolism stabilization, validate its promising inclusion while evaluating the
individual and activity-specific needs. It is reputable insight and evidence-based guidance that should
ultimately shape its strategic application across diverse sporting disciplines to ensure continued
health and enhanced athletic achievements.
What potential research directions exist for
Cyclo(Val-Val) in sports nutrition science?
In the rapidly evolving landscape of sports nutrition
science, Cyclo(Val-Val) presents several intriguing avenues for future research, with implications that
could broaden the foundational understanding of its mechanisms and benefits in athletic performance and
recovery. One primary area worthy of exploration is the compound's precise biochemical impact on human
physiology, specifically within muscle tissues during and after exertion. Detailed investigations
concerning its influence on energy metabolism, muscle repair pathways, and biochemical markers of
exercise-induced oxidative stress could illuminate deeper insights into efficiency and optimization for
athletic applications. Additionally, there lies substantial scope for clinical trials and larger
epidemiological studies to assess the longer-term safety and efficacy of Cyclo(Val-Val) supplementation,
its optimal dosing strategies, potential synergies with other nutritional supplements or dietary
protocols, and its extended impact across diverse athletic populations and exercise modalities. These
studies could further incorporate musculoskeletal imaging or inflammatory biomarker analysis for more
nuanced assessments. Another potential research direction could revolve around the exploration of
neuroprotective effects, given initial laboratory findings suggestive of cognitive and nerve-protection
attributes, ultimately expanding the application realm of Cyclo(Val-Val) beyond conventional physical
performance enhancement, possibly aiding cognitive performance or neurological health. The biomechanical
implications of Cyclo(Val-Val) regarding exercise-related fatigue, optimizing mitochondrial activity or
interplay with skeletal muscle plasticity and aging also present potentially groundbreaking fields.
Moreover, technological advancements like metabolomics or proteomics present instrumental tools for
researching molecular interactions and effects to understand systemic impacts within body systems under
athletic loads. Ultimately, the goal of emerging research into Cyclo(Val-Val) within sports nutrition is
to ground its potential benefits in empirical evidence, enhancing both application precision and safety
assurance for individuals deploying it within their health, performance, or recovery strategies in
athletics or active lifestyles.