Synonym |
Gastrin-TEWV |
Species |
Human |
Protein Accession |
P09683 |
Purity |
> 95% |
Endotoxin Level |
< 1 EU per 1 μg of the protein |
Biological Activity |
N/A |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
1.2 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA |
Reconstitution |
It is recommended to reconstitute the lyophilized Gastrin Tetrapeptide in sterile 18 MΩ-cm H2O
not less than 100 μg/ml, which can then be further diluted to other aqueous solutions. |
Storage & Stability |
Lyophilized Gastrin Tetrapeptide although stable at room temperature for 3 weeks, should be
stored desiccated below -18°C. Upon reconstitution Gastrin Tetrapeptide should be stored at 4°C
between 2-7 days and for future use below -18°C. For long term storage it is recommended to add
a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
FAQ
What is Gastrin Tetrapeptide and how does it benefit the human body?
Gastrin Tetrapeptide is a
fascinating compound that has gained significant attention in recent years due to its potential
physiological effects on the human body. It's a short peptide, comprising four amino acids, and is a
derivative of the naturally occurring hormone gastrin. Gastrin itself plays a crucial role in the
digestive system by stimulating the secretion of gastric acid from the stomach lining, which is
essential for proper digestion and nutrient absorption. Similarly, Gastrin Tetrapeptide is thought to
have properties that can mimic some of the functions of this hormone, albeit on a much smaller scale.
Research suggests that Gastrin Tetrapeptide may have several intriguing benefits beyond aiding
digestion. One of the primary areas of interest is its potential role in promoting skin health. The
peptide is thought to stimulate collagen production, which is essential for maintaining skin elasticity
and firmness. As we age, collagen production naturally declines, leading to the formation of wrinkles
and sagging skin. By potentially boosting collagen synthesis, Gastrin Tetrapeptide may help mitigate
some of these aging processes, making it an attractive component in anti-aging skincare
products.
Moreover, Gastrin Tetrapeptide has been studied for its anti-inflammatory properties.
Chronic inflammation can accelerate the aging process and contribute to a wide array of health issues,
including skin problems. Inflammation is often the body's response to injury or infection, but when it
becomes chronic, it can cause more harm than good. By potentially reducing inflammation, Gastrin
Tetrapeptide could help in managing conditions where inflammation is a key factor.
Additionally,
there is ongoing research into the peptide's role in gut health. A healthy digestive system is crucial
for overall well-being, and Gastrin Tetrapeptide may aid in the maintenance of gut lining integrity.
This could potentially help prevent conditions like leaky gut syndrome, where the intestinal lining
becomes permeable, allowing toxins and waste products to seep into the bloodstream.
While much of
the scientific inquiry into Gastrin Tetrapeptide is still in its early stages, the compound offers a
promising glimpse into its multifaceted benefits. Continued research and clinical trials will likely
shed more light on its efficacy and safety, but its potential in skin care and gut health, backed by its
anti-inflammatory properties, makes it a potent player in both the wellness and cosmetic
industries.
Are there any known side effects associated with the use of Gastrin
Tetrapeptide?
Like any compound or supplement, the use of Gastrin Tetrapeptide may come with
certain considerations and potential side effects, though it is generally considered safe when used
appropriately. The primary action of Gastrin Tetrapeptide is to mimic certain aspects of the naturally
occurring hormone gastrin. While this can have beneficial effects, it also means that if used
excessively, there could be an overstimulation of gastric acid production. Excess gastric acid can lead
to discomfort, heartburn, or even contribute to the development of peptic ulcers in susceptible
individuals. However, it's important to note that the concentration of Gastrin Tetrapeptide used in most
products is typically low and designed to minimize such risks.
Another aspect to consider is
allergic reactions. As with any peptide or protein-based product, there is a potential for an allergic
reaction, although such instances tend to be rare. It's always prudent for individuals trying a new
compound to perform a patch test, especially when using topical applications, to ensure there is no
adverse reaction.
Moreover, since Gastrin Tetrapeptide is relatively new and ongoing research
continues to explore its properties, long-term studies are limited. This means that while short-term
applications appear to be safe, the long-term effects are not fully understood. Individuals with
pre-existing conditions, especially those related to the digestive tract, should consult a healthcare
provider before using products containing Gastrin Tetrapeptide to avoid unwanted interactions or
exacerbations of their conditions.
For those considering over-the-counter products containing
Gastrin Tetrapeptide, it's crucial to use them as directed by the manufacturer or a healthcare
professional. Misuse or overuse can sometimes lead to side effects that might not otherwise occur with
proper use. Furthermore, given that this compound can promote collagen synthesis, individuals with
sensitive skin should approach its use cautiously to avoid potential irritation or exacerbation of
sensitive skin conditions.
In conclusion, Gastrin Tetrapeptide holds promise for various health
applications, particularly in skin care, due to its collagen-boosting and anti-inflammatory properties.
While generally safe, it's wise to approach its use with care, especially for individuals with
underlying health concerns. Consulting with a healthcare provider can ensure that its use aligns well
with an individual's overall health profile and goals.
How does the mechanism of Gastrin
Tetrapeptide differ from regular gastrin?
Gastrin Tetrapeptide and regular gastrin share certain
biochemical characteristics due to their similar molecular structure, but they operate distinctively
within the body due to their differences in size and specific activity. Regular gastrin is a peptide
hormone produced in the stomach and plays a vital role in the digestive system by stimulating the
secretion of gastric acid. This process is crucial for breaking down food and enabling nutrient
absorption. Gastrin operates through binding to specific receptors on parietal cells in the stomach
lining, triggering a cascade of biochemical signals that result in increased acid production. It also
plays a role in enhancing the motility of the stomach and gut as well as promoting the growth of gastric
mucosa.
In contrast, Gastrin Tetrapeptide is a shorter derivative of gastrin, comprising four
amino acids. This truncated structure influences its mechanism of action and the scope of its effects.
Primarily, Gastrin Tetrapeptide is leveraged for its localized effects rather than systemic ones. This
means that while it can mimic some of the beneficial actions of gastrin such as promoting gastric
mucosal activities and possibly aiding digestion, it is often utilized for its ability to induce
collagen production and exhibit anti-inflammatory properties when applied topically or used in specific
therapeutic applications.
The truncated nature of Gastrin Tetrapeptide allows it to target
particular pathways that may influence skin health and inflammation without inducing the broad-spectrum
actions typically associated with the full gastrin hormone. This specificity can offer advantages,
particularly in the domain of skin care and targeted therapeutic applications. For example, by focusing
on collagen synthesis, Gastrin Tetrapeptide becomes a potent ingredient in anti-aging formulations,
promoting skin firmness and elasticity without necessarily stimulating gastric acid secretion, which is
not desired in a topical application.
Furthermore, due to its reduced complexity and defined
action site, Gastrin Tetrapeptide might offer fewer side effects related to digestive enzyme
overproduction, presenting a safer option for individuals when used in specific non-digestive contexts.
Overall, while both molecules share lineage and some functional similarities, their practical
applications, potential benefits, and risks diverge significantly due to their structural differences
and resultant mechanisms of action.
Can Gastrin Tetrapeptide be incorporated into a daily
skincare routine, and what are its potential benefits?
Incorporating Gastrin Tetrapeptide into a
daily skincare routine can indeed be beneficial, thanks to its multifactorial properties that may
contribute to skin health and appearance. Gastrin Tetrapeptide has garnered interest in the cosmetic and
dermatological fields due to its purported ability to stimulate collagen production and modulate
inflammatory responses, both of which are critical factors in maintaining youthful and healthy
skin.
One of the hallmark potential benefits of using products containing Gastrin Tetrapeptide is
its ability to encourage collagen synthesis. Collagen is an essential protein in the skin that provides
structure, firmness, and elasticity. As people age, collagen levels in the skin naturally decrease,
leading to common signs of aging, such as fine lines, wrinkles, and sagging. By potentially stimulating
collagen production, Gastrin Tetrapeptide can help to counteract these age-related changes, smoothing
out wrinkles and enhancing the overall texture and tone of the skin.
In addition to promoting
collagen, Gastrin Tetrapeptide may exhibit anti-inflammatory effects. Chronic inflammation is a known
contributor to skin aging and various skin conditions. By reducing inflammation, this peptide can help
soothe the skin, reduce redness and irritation, and contribute to an overall healthier complexion. This
makes products containing Gastrin Tetrapeptide particularly appealing to individuals with sensitive skin
or those suffering from inflammatory skin conditions such as rosacea or acne.
When considering
how to incorporate Gastrin Tetrapeptide into a skincare routine, it's worth noting that it is often
formulated within creams, serums, or topical treatments. These products are usually applied after
cleansing and toning but before moisturizing, allowing the active ingredient to penetrate deeply and
exert its effects. Consistent use, as directed by the product guidelines or a skincare professional, can
maximize potential benefits.
However, it is important to recognize that while the science behind
Gastrin Tetrapeptide is promising, individual results can vary based on skin type, existing skin
conditions, and the overall composition of the skincare regimen. Therefore, individuals interested in
integrating this peptide should consider conducting a patch test to ensure no adverse reaction occurs
and perhaps consult with a dermatologist to tailor its use effectively within their skincare
routine.
In summary, Gastrin Tetrapeptide presents an exciting option for skincare enthusiasts
aiming to enhance their routine with scientifically-backed ingredients that promote collagen and soothe
inflammation. As part of a well-rounded skincare regimen, it can contribute significantly to the
rejuvenation and maintenance of healthy, vibrant skin.
Is Gastrin Tetrapeptide suitable for all
skin types, including sensitive skin?
Gastrin Tetrapeptide is generally regarded as suitable for
a variety of skin types, including sensitive skin, due to its potential beneficial properties and
relatively low risk of irritation. Nonetheless, there are certain nuances and considerations that
individuals with different skin types should keep in mind when introducing a new peptide-based product
into their skincare regimen. Gastrin Tetrapeptide is primarily lauded for its collagen-promoting and
anti-inflammatory capabilities, making it an attractive option for those looking to address signs of
aging or soothe inflamed skin.
For individuals with normal to oily skin, Gastrin Tetrapeptide can
be an excellent addition to a skincare routine aimed at preventing the premature appearance of wrinkles
and maintaining skin firmness. Its ability to enhance collagen production aligns well with the goals of
maintaining elasticity and reducing the visibility of pores, which can be benefits particularly sought
after by individuals with oily skin types.
Those with dry skin can also find Gastrin Tetrapeptide
beneficial. Dry skin can sometimes lead to increased visibility of fine lines and wrinkles due to a lack
of moisture and elasticity. By incorporating a peptide that potentially boosts collagen and supports the
skin's barrier function, individuals with dry skin may notice improvements in hydration retention and
texture, resulting in a more supple appearance.
Sensitive skin types could potentially benefit
from using Gastrin Tetrapeptide as well, due to its proposed anti-inflammatory effects. Reducing
inflammation can be particularly important for sensitive skin, which often reacts strongly to various
environmental and product-related stimuli. Nevertheless, despite its generally favorable profile,
individuals with sensitive skin should introduce any new product gradually and monitor their skin for
any adverse reactions, such as redness or irritation, which could suggest the need to adjust frequency
or method of application.
Additionally, it's crucial for individuals, particularly those with
sensitive or reactive skin, to conduct a patch test when using new products containing active
ingredients like Gastrin Tetrapeptide. This precaution helps ensure the skin tolerates the compound
without negative effects. Furthermore, as with any new addition to a skincare routine, consulting with a
dermatologist can provide personalized insights and recommendations based on one's specific skin type
and history.
In conclusion, while Gastrin Tetrapeptide is versatile and potentially beneficial
for all skin types, including sensitive skin, individual experiences may vary. It's essential to
approach its use thoughtfully, starting slowly and seeking professional advice when needed, to ensure
the maximum benefits are realized without compromising skin health.