Synonym |
Hydrin 1% (Arg8,Gly10,Lys11,Arg12)-Vasotocin |
Species |
Human |
Protein Accession |
P01185 |
Purity |
Greater than 95% as determined by SDS-PAGE |
Endotoxin Level |
Less than 1 EU/μg |
Biological Activity |
Not available |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
1056.2 Da |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4 |
Reconstitution |
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
|
Storage & Stability |
Store at -20°C. Avoid repeated freeze/thaw cycles. |
FAQ
What is Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin and its primary usage?
Hydrin 1,
(Arg8,Gly10,Lys11,Arg12)-Vasotocin is a synthetic peptide that is derived from the naturally occurring
hormone vasotocin, a nonapeptide that shares similarities with the mammalian oxytocin and vasopressin.
Vasotocin is often found in amphibians, reptiles, and birds, and is believed to play a significant role
in osmoregulation, the modulation of the social behaviors, and the reproductive processes of these
species. By expanding its properties synthetically, Hydrin 1 is designed to target specific
physiological and biochemical processes that are influenced by vasotocin. Research into its application
has suggested its potential for enhancing water retention and reducing urinary excretion, making it a
candidate for addressing conditions related to body fluid balance. Furthermore, Hydrin 1 has been
explored for its capacity to regulate stress responses, social interactions, and territorial aggression
in model animals. Its usage, however, is primarily confined to research environments as its full effects
and efficacy in human subjects require further investigation. This peptide's exploration continues to
reveal intricate pathways through which it exerts influence, offering a foundational comprehension that
could inspire new directions in therapeutic interventions about hormonal regulation and water balance
mechanisms.
How does Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin affect hormonal regulation in
the body?
Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin functions by mimicking or interfering with
the activity of vasotocin, a naturally occurring hormone structurally similar to oxytocin and
vasopressin that are found in a vast array of animals, including amphibians, birds, and reptiles. This
peptide’s influence on hormonal regulation stems from its ability to bind to vasotocin receptors, which
are closely related to the vasopressin and oxytocin receptors found in mammals. By doing so, it plays a
key role in the modulation of several physiological processes, including water balance and social
behavior, two areas extensively controlled by the hormonal systems in vertebrates. These receptors, when
activated by Hydrin 1, can trigger a cascade of intracellular events that impact various physiological
outcomes. The peptide's ability to enhance or inhibit the functions mediated by its receptor has
implications for the modulation of stress response mechanisms, facilitation of reproductive tactics, and
social hierarchy establishment in certain animals. In research settings, Hydrin 1’s effects have been
analogized to those of vasopressin, as it often influences kidney function and water retention
mechanisms, showing potential in correcting dysregulations of fluid balance. Moreover, this peptide can
influence emotional states by affecting neurons involved in socio-emotional processing, thereby
augmenting interest in its potential uses for stress-related and social disorders. Although much of
Hydrin 1's mechanisms are studied within non-mammalian systems, its analogy to mammalian hormones
suggests intriguing cross-species implications and warrants further exploration in potential therapeutic
applications.
Can Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin influence social behaviors or
cognitive functions?
Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin is noted for its capacity to
influence social behaviors, a characteristic derived from its structural and functional similarities to
vasotocin, which is intimately involved in the regulation of social and reproductive behaviors in many
non-mammalian vertebrates. Research conducted on various animal models has demonstrated that vasotocin,
the natural counterpart of Hydrin 1, is integral in modulating social interactions such as mating and
aggressive behaviors. Hydrin 1, by mimicking or modulating this hormone's activity, could therefore
present similar effects. The intricacies of its mechanism are suggested to stem from its interactions
with central nervous system receptors that are comparable to those binding mammalian oxytocin and
vasopressin, which are widely recognized regulators of social and affiliative behaviors in humans. By
influencing these neural pathways, Hydrin 1 could enhance or suppress behaviors associated with social
bonding or aggression. Its role becomes particularly pertinent in species where vasotocin's effects are
apparent, indicating potential regulatory impacts of Hydrin 1 on complex social hierarchies and breeding
behaviors. While direct cognitive functions impacted by Hydrin 1 remain a relatively unexplored field
due to its primary research focus on animal models, exploratory evidence suggests that its modulatory
capabilities might extend to cognitive processes indirectly by altering social contexts. For instance,
enhanced social interaction facilitated by Hydrin 1 may contribute to modifications in learning
environments or stress coping mechanisms, thus having a secondary impact on cognitive ability. However,
further extensive studies are required to establish these roles accurately and to understand the
potential translational effects in humans where such social cognition interplay is far more nuanced and
complex.
In what research areas is Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin being
investigated?
Research into Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin primarily revolves around
several developmental and therapeutic inquiries linking its application to biological and behavioral
phenomena. One significant research area involves the peptide’s role in osmoregulatory mechanisms.
Scientists are keenly exploring how Hydrin 1 mimics or modifies the system of water balance in
organisms, particularly in species native to water-variable environments like amphibians and reptiles.
By understanding Hydrin 1's influence on water intake and excretion, researchers aim to unravel new
insights into fluid homeostasis processes, potentially translating these findings to manage human
conditions of water imbalance or dehydration-induced disorders. Furthermore, its impact on reproductive
physiology and behavior is another critical domain, as vasotocin analogs like Hydrin 1 have shown
effects on mating behaviors and territoriality in non-mammalian vertebrates. Investigations into this
area could inform breeding programs or elucidate the underlying hormonal pathways that influence
reproductive success. Additionally, the peptide’s similarity to neurohormones found in mammals has
directed research towards potential neurobiological applications. This includes studying its potential
to influence social behaviors, stress responses, and endocrine system interactions. Studies aimed at
understanding its effects on brain function desire to map out neural circuitry impacts, which might
provide a comparative basis for examining analogous human systems. Finally, therapeutic exploration
includes evaluating Hydrin 1's properties to devise novel treatments for social disorders or hormonal
dysregulation conditions. By investigating these multifaceted dimensions, researchers strive to fully
elucidate the peptide’s scope and foster advancements that bridge innate physiological insights with
consequential medical advancements.
Are there any potential side effects or concerns associated
with the use of Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin?
As with any peptide or hormone analog,
understanding the potential side effects or concerns associated with Hydrin 1,
(Arg8,Gly10,Lys11,Arg12)-Vasotocin is crucial, although much of the assessment is in early research
stages. Since the peptide is predominantly studied under controlled research settings, comprehensive
profiles of adverse reactions have yet to be fully established. Nevertheless, given its profound
influence on hormone-related activities, certain general considerations can be noted. First, the
modulation of water balance could lead to unintended interference with homeostatic functions, especially
if the peptide influences kidney function and fluid retention excessively. This could lead to states of
either water overload or depletion, each carrying subsequent physiological risks. Additionally, its
impact on social behaviors raises potential considerations around aggression modulation and stress
responses, especially within species where these characteristics are finely balanced by endogenous
vasotocin. Understanding these dynamics within human analogs becomes intricately complex, given the
broader social and psychiatric implications of modifying such pathways. Furthermore, any synthetic
peptide's introduction carries the risk of immune responses, where the body might recognize the compound
as foreign, potentially leading to allergic reactions or immune-mediated side effects. Ethical concerns
and safety profiles thus prioritize conducting controlled studies to evaluate not only efficacy but the
peptide's safety thresholds as well. Those engaging in or supporting research with Hydrin 1 must remain
vigilant about dosing concerns, administration routes, and long-term exposure outcomes. Until more
extensive clinical trials and detailed safety assessments are completed, recommendations around its
application emphasize maximizing the therapeutic explorations while meticulously monitoring adverse
effects to better inform future usage.
What are the potential therapeutic applications of Hydrin
1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin for human health?
Given its influential role within biological
systems, Hydrin 1, (Arg8,Gly10,Lys11,Arg12)-Vasotocin presents several potential therapeutic
applications that could extend to human health. Prerequisite to such applications is the extensive
research and translation of findings from non-mammalian studies to mammalian models. In fields related
to fluid balance and kidney function, for instance, the peptide’s impact on water retention and
excretion could offer new approaches to managing conditions characterized by fluid imbalance. This
includes the potential development of treatments for dehydration, diabetes insipidus, or edema where
conventional therapies may require alternative or adjunctive strategies. Additionally, Hydrin 1’s
similarity to oxytocin and vasopressin opens avenues for its use in addressing social and behavioral
disorders. Research into its neurobehavioral effects could yield insights applicable to conditions such
as autism spectrum disorders or social anxiety, wherein modulation of social behavior pathways may prove
beneficial. The peptide’s ability to impact stress response mechanisms also supports investigations into
its use for stress-induced conditions, which could encompass stress-related metabolic syndromes or
anxiety disorders. Applications within reproductive health, influenced by its role in non-mammalian
reproduction, suggest potential for addressing infertility issues linked to hormonal dysregulation. By
directly modulating pathways shared with oxytocin and vasopressin, Hydrin 1 might also influence
conditions of labor induction or control. Scientifically grounded optimism thus surrounds these
therapies, although realization and implementation remain contingent upon extensive clinical validation
and safety profiling. The pursuit of new therapeutic paths with Hydrin 1 not only necessitates robust
scientific inquiry but also shines a light on the harmonization of our understanding of cross-species
hormone functionality to address complex human health challenges endogenously.