Synonym |
Hydrin 2% (Arg8,Gly10)-Vasotocin |
Species |
Human |
Protein Accession |
P01185 |
Purity |
≥ 95% |
Endotoxin Level |
< 1 EU/μg |
Biological Activity |
Not specified |
Expression System |
E. coli |
Fusion Tag |
No tag |
Predicted Molecular Mass |
1084.22 Da |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20% acetonitrile in 0.1% trifluoroacetic acid
|
Reconstitution |
It is recommended to reconstitute the lyophilized product with sterile water at a concentration
of 0.1 mg/ml, which can then be further diluted to other aqueous solutions |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot reconstituted protein and store at -80°C. Avoid
repeated freeze-thaw cycles. |
FAQ
What is Hydrin 2, (Arg8,Gly10)-Vasotocin, and what are its primary applications?
Hydrin 2, also
known as (Arg8,Gly10)-Vasotocin, is a synthetic analog of the naturally occurring peptide known as
vasotocin. Vasotocin itself is a nonapeptide that serves important roles in various animal species,
especially in birds, reptiles, and amphibians. It is often considered homologous to both arginine
vasopressin and oxytocin found in mammals. The significance of Hydrin 2 lies in its ability to replicate
some of the essential biological activities of vasotocin, which makes it a vital tool in scientific
research exploring neuroendocrinology, behavior, and evolutionary biology. One of its primary
applications is in the study of social behavior and stress responses across different
species.
Hydrin 2 is invaluable in research due to its ability to bind to vasotocin receptors,
which are ancestral to the vasopressin and oxytocin receptors found in mammals. These receptors are
known to influence an array of physiological processes including water balance, blood pressure
regulation, and reproduction. In the context of behavioral studies, Hydrin 2 is employed to investigate
its effects on social bonding, mating behaviors, and aggression. By observing these interactions,
researchers can gain insights into the evolutionary mechanisms that guide social relations and
environmental adaptations.
Furthermore, Hydrin 2 is also significant in agricultural studies.
Understanding its role in avian species, for example, can aid in developing strategies for optimizing
reproduction or managing stress in poultry, thereby contributing to more efficient and humane farming
practices. It lends itself to conservation efforts as well, as it helps in understanding how various
species might adapt to changing environmental stresses or social structures within their populations.
Additionally, insights drawn from such studies may also be applicable to understanding endocrine systems
in humans, potentially aiding in the development of treatments for disorders related to water retention,
blood pressure, and social behavioral issues.
Overall, the application of Hydrin 2 reaches beyond
basic scientific inquiry; it can influence ecological management and animal husbandry while potentially
offering translational insights applicable to human health. Its versatility as a research compound
underscores its importance in bridging gaps between comparative physiology and applied sciences.
Researchers harnessing Hydrin 2 are thus poised to glean transformative insights that span diverse
fields, strengthening our comprehension of biological frameworks and evolutionary links across
species.
How does Hydrin 2, (Arg8,Gly10)-Vasotocin, compare to traditional vasopressin and
oxytocin in terms of functionality and research importance?
Hydrin 2, (Arg8,Gly10)-Vasotocin,
shares significant structural and functional similarities with the well-known peptides vasopressin and
oxytocin. However, it holds distinct differences in terms of evolutionary context and specific receptor
interactions which make it particularly valuable for research in non-mammalian species. While
vasopressin and oxytocin are predominant in mammals and widely studied for their roles in regulating
water retention, blood pressure, and social behaviors, Hydrin 2 offers a broader panorama into the
ancestral pathways of these peptides.
Functionally, vasotocin acts akin to both vasopressin and
oxytocin, being involved in osmoregulation and social behaviors. However, its functionality is broader,
as it serves as a prototype to understand the evolutionary transition of these hormones. Despite these
similarities, it holds distinctive roles across various species that are not fully replicated by the
mammalian hormones. Vasotocin tends to influence behaviors such as territoriality, mating, and nesting
particularly within birds and amphibians. Therefore, studying Hydrin 2 can provide a unique window into
understanding how certain social behaviors evolved as well as how they are maintained or modified in
animal populations.
From an evolutionary biology perspective, Hydrin 2 highlights the molecular
divergence and adaptation occurring over millions of years that led to the specialized roles of
vasopressin and oxytocin in mammals. This makes it an indispensable tool not only for comparative
studies across different phylogenetic lineages but also for reconstructing the functional evolution of
neuropeptides. Additionally, Hydrin 2's ability to activate both oxytocin and vasopressin receptors
underlines its versatility and why it's a compound of interest for comprehensive receptor pathway
studies.
While vasopressin and oxytocin are extensively linked to clinical applications because
of the vast array of physiological processes they influence in humans, Hydrin 2 is mostly pivotal in the
domain of basic research. However, the lessons learned from Hydrin 2 can potentially inform medical
research as they unravel foundational aspects of receptor functionality and evolutionary conserved
mechanisms that might mirror pathophysiological conditions in humans. Ultimately, it holds significant
promise in evolutionary biology, endocrinology, and behavioral science, aiding the understanding of
complex interactions within natural habitats that might otherwise go unnoticed if relying solely on the
mammalian models.
What scientific investigations are advanced by the use of Hydrin 2,
(Arg8,Gly10)-Vasotocin?
Hydrin 2, (Arg8,Gly10)-Vasotocin, plays a pivotal role in various
scientific investigations, particularly in the fields of endocrinology, neurobiology, and evolutionary
biology. The unique properties of Hydrin 2 enable researchers to explore the effects of neuropeptides on
animal behavior and physiology in ways that traditional studies using vasopressin and oxytocin do not
fully capture. One significant area of study is the investigation of social behaviors in non-mammalian
species, such as birds, amphibians, and reptiles. These studies aim to better understand the
physiological underpinnings of behaviors like mating rituals, parental care, and territorial aggression.
Hydrin 2 serves as a crucial variable in experiments designed to discern how hormonal pathways influence
such complex behavioral patterns.
In addition to behavioral studies, Hydrin 2 is extensively
used to understand mechanisms of osmoregulation and stress response across different species. This
nonapeptide is known to be intricately involved in regulating the balance of water and salts within an
organism, particularly within avian species. Through detailed analyses, scientists seek to delineate how
Hydrin 2 helps animals adapt to varying environmental conditions, which could have implications for
understanding climate adaptability among wildlife. Furthermore, research using Hydrin 2 delves into how
neuropeptide systems have evolved, bridging the gap between primitive hormonal systems and the more
advanced neuroendocrine systems found in higher vertebrates.
The insights gained from these
studies not only elucidate the adaptive strategies used by different species but also provide
comparative models that may mimic certain human biological processes, offering indirect benefits to
medical science. Hydrin 2's influence extends to agricultural science as well, where it aids in
examining the effects of stress and reproduction in livestock, potentially influencing practices aimed
at improving animal welfare and productivity. Conservation biology also benefits from investigations
with Hydrin 2, as it helps identify how natural or anthropogenic stressors might affect the physiology
and behaviors of endangered species, which is crucial for developing effective management strategies.
All these facets underline the multifaceted applications of Hydrin 2 in scientific inquiry,
demonstrating how a single peptide can enhance our understanding of biology and improve applied
scientific methodologies across a range of disciplines.
What are the potential benefits of
studying Hydrin 2, (Arg8,Gly10)-Vasotocin, in birds?
Exploring the effects of Hydrin 2,
(Arg8,Gly10)-Vasotocin, in birds opens the door to a multitude of insights into avian biology,
particularly in understanding how neuroendocrine mechanisms regulate behavioral and physiological
processes. One of the key benefits of studying Hydrin 2 in birds lies in its role in deciphering complex
social behaviors. Bird species exhibit a diverse array of social structures and mating systems, from
monogamy to polygyny, making them ideal models for examining how peptides like Hydrin 2 influence social
bonding, hierarchical interactions, and reproductive strategies. By manipulating levels of Hydrin 2 and
observing resultant behavioral changes, researchers can infer how hormonal pathways dictate mating
rituals, territorial defense, and parental care behaviors. These insights can subsequently be correlated
with evolutionary pressures that have shaped these behaviors, providing a deeper understanding of the
adaptive significance of social structures in avian life.
Aside from its behavioral implications,
Hydrin 2 also offers critical benefits for physiological studies. As a regulator of osmoregulation, it
plays a fundamental role in adaptation to different environmental conditions, especially in bird species
that inhabit arid or saline environments. By studying Hydrin 2 in these species, scientists gain a
clearer understanding of the physiological adjustments that allow birds to thrive in challenging
habitats. Such knowledge could be invaluable in predicting how birds might cope with the ongoing impacts
of climate change, which presents new challenges in terms of resource availability and habitat
conditions.
Furthermore, examining the effect of Hydrin 2 on avian physiology can have direct
applications in conservation science. Through understanding how it affects stress responses, researchers
can better assess the impact of habitat disruption and human-induced environmental changes on bird
populations. Effective conservation strategies can then be devised, targeting enhancements in habitat
management and amelioration of stressors that impact breeding success and survival rates.
In
aviculture and poultry science, research into Hydrin 2 might lead to enhancements in breeding programs
by optimizing conditions conducive to desired behaviors and stress management. This has implications not
only for production efficiency but also for animal welfare standards. Overall, the benefits of studying
Hydrin 2 in birds are extensive, providing vital contributions to behavioral ecology, physiology,
conservation, and agriculture, thereby facilitating a holistic understanding of avian species in their
natural and managed environments.
How does the study of Hydrin 2, (Arg8,Gly10)-Vasotocin,
contribute to our understanding of evolutionary biology?
The study of Hydrin 2,
(Arg8,Gly10)-Vasotocin, is instrumental in unraveling the complexities of evolutionary biology,
particularly concerning the evolution of endocrine and neuroendocrine systems across vertebrates.
Vasotocin is often considered an ancestral peptide from which the mammalian peptides vasopressin and
oxytocin evolved. By studying Hydrin 2, researchers can glean insights into the evolutionary journey of
neuropeptide systems and understand how these molecules have adapted to fulfill varied and complex
biological roles in different species.
In exploring Hydrin 2, scientists can trace the
phylogenetic differences in receptor binding affinities and responses to the peptide across a diverse
array of species. These studies contribute to a more comprehensive understanding of the molecular
evolution of receptor-ligand interactions, highlighting the adaptive modifications that have been shaped
by evolutionary pressures. The results enhance our grasp of how ancient peptide systems have diversified
in structure and function, giving rise to the sophisticated hormonal networks observed in modern
vertebrates.
Through comparative studies using Hydrin 2, researchers are also able to understand
the evolutionary roots of social behaviors, providing a framework for evaluating how such behaviors
might have conferred selective advantages. By identifying the conserved and divergent elements of
vasotocin-mediated behaviors, scientists can hypothesize how certain social traits evolved in response
to environmental challenges. This is invaluable for reconstructing the behavioral evolution of
lineage-specific traits that are crucial for survival and reproduction.
Moreover, Hydrin 2 serves
as a model for studying the evolution of osmoregulatory and stress response mechanisms. Given its role
in regulating water balance and adaptation to environmental stresses, research on Hydrin 2 helps explain
how different species evolved strategies for maintaining homeostasis under varying ecological
conditions. This aids in understanding the evolutionary pathways that have led to the phenotypic
diversity observed in today's vertebrate populations, underpinning the adaptability and resilience of
life forms in dynamic ecosystems.
Ultimately, Hydrin 2 not only contributes to the field of
evolutionary biology by providing insights into the fundamental processes that drive biological
diversity and organismal adaptation but also reinforces the interconnected nature of life, offering
perspectives that improve our overall comprehension of biological evolution and its impacts on current
biodiversity.