Synonym |
KRELVEPLTPSGEAPNQALLR |
Species |
Human |
Protein Accession |
P02743 |
Purity |
Greater than 95% as determined by SDS-PAGE |
Endotoxin Level |
Less than 1 EU/ug |
Biological Activity |
The activity was determined by the dose-dependent stimulation of the proliferation of
5 E.GFPIL-2R cells is ≤ 1.0 ng/mL. |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
11.2 kDa |
Formulation |
Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl, pH 7.4 |
Reconstitution |
It is recommended to reconstitute the lyophilized protein in sterile water to a concentration no
less than 100 µg/ml. |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated
freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of
time. The lyophilized protein remains stable until the expiry date when stored at -20°C. |
FAQ
What is KRELVEPLTPSGEAPNQALLR, and what does it do?
KRELVEPLTPSGEAPNQALLR represents a sequence of
amino acids, which are the building blocks of proteins. Each letter in the sequence corresponds to a
specific amino acid based on the standard code used in biochemistry. To understand the significance of
KRELVEPLTPSGEAPNQALLR, one must appreciate the role of proteins in biological systems. Proteins are
essential macromolecules that assist in almost every biological process. They serve various functions
such as catalyzing metabolic reactions, replicating DNA, responding to stimuli, and transporting
molecules. A sequence like KRELVEPLTPSGEAPNQALLR likely constitutes a specific segment of a protein,
which could be part of a biological pathway. Analyzing such sequences provides insights into protein
structure and function, which is critical in fields like biochemistry, molecular biology, and
biotechnology. Researchers often study these sequences to understand how changes in amino acids might
affect protein functionality, and this could lead to advancements in health sciences or therapeutic
development. Whether this sequence plays a role in disease processes, cellular mechanisms, or enzyme
functionality depends on the broader protein context it belongs to. Ultimately, understanding these
sequences opens the door to drug design and development, where researchers can target specific protein
segments or modify them to gain desired biological effects. KRELVEPLTPSGEAPNQALLR is thus more than just
a sequence of letters; it's a key to unlocking complex biological behaviors and designing innovative
solutions in life sciences.
How can KRELVEPLTPSGEAPNQALLR be used in scientific research?
The
usage of a peptide or protein sequence like KRELVEPLTPSGEAPNQALLR in scientific research is vast and
varied, largely because such sequences can hold critical information about a protein's properties and
potential functions. In proteomics, which involves the large-scale study of proteins, researchers might
use this sequence to explore its role in cellular functions or biochemical pathways. Sequences like
KRELVEPLTPSGEAPNQALLR can be synthesized and used in laboratory experiments to observe interactions with
other proteins, nucleic acids, or small molecules, thereby gaining more nuanced insights into cellular
processes or disease mechanisms. Such studies could contribute to the discovery of novel biomarkers for
diseases, leading to earlier diagnosis and better targeted treatment regimens. Additionally, in
structural biology, this sequence might undergo analyses such as X-ray crystallography or nuclear
magnetic resonance (NMR) to determine the three-dimensional structure of the protein it forms part of.
Understanding the structure aids in predicting how proteins interact with each other and with
pharmaceutical compounds, oftentimes guiding drug design efforts. With recent advances in computational
tools and bioinformatics, sequences like KRELVEPLTPSGEAPNQALLR can be explored through in silico
simulations to predict their behavior in complex biological systems, often archiving significant time
and resources otherwise spent on experimental procedures. Beyond foundational research, such sequences
are relevant in applied research fields such as synthetic biology, where they could be manipulated to
produce new materials or novel therapeutic applications. Altogether, research involving sequences like
KRELVEPLTPSGEAPNQALLR promises breakthroughs across various domains of science, laying the groundwork
for future innovations in health and life sciences.
What potential applications does
KRELVEPLTPSGEAPNQALLR have in medicine?
Peptide sequences such as KRELVEPLTPSGEAPNQALLR might hold
tremendous potential in medical applications due to the roles peptides and proteins play in
physiological processes. Understanding the specifics of what peptides do at the molecular level can lead
to innovations in drug development and disease treatment. For instance, such sequences can be involved
in the development of peptide-based drugs, which are gaining attention thanks to their high specificity
and efficacy compared to traditional small molecule drugs. These drugs have been shown to target
specific proteins and modulate biological functions effectively, often with few side effects.
Additionally, tailored peptides like KRELVEPLTPSGEAPNQALLR can equate to a customizable therapy platform
and are being explored for use in treating conditions such as cancer, diabetes, and autoimmune diseases.
In diagnostics, these sequences are critical in developing tools that can detect biomarkers indicative
of diseases. The specificity and sensitivity of peptides allow for highly accurate diagnostic assays,
which facilitate early diagnosis and monitoring of disease stages, contributing to more effective
management strategies. Another promising avenue is their application in vaccine development. Peptides
can be used to stimulate the immune system against pathogens, offering a basis for designing peptide
vaccines that are safe and effective. This has become particularly relevant in the recent spotlight on
infectious diseases where rapid vaccine deployment is critical. Furthermore, these sequences can be
explored in regenerative medicine, where they serve as bioactive molecules encouraging tissue repair and
regeneration, or as components of scaffolds providing structural support in tissue engineering. While
KRELVEPLTPSGEAPNQALLR might be just one of countless sequences, the potential applications for these
molecular constructs in modern medicine underscore their importance and promise significant benefits for
future healthcare advancements.