Synonym |
Neuronostatin-13 |
Species |
Human, canine, porcine |
Protein Accession |
NA |
Purity |
> 95% |
Endotoxin Level |
< 1 EU/µg |
Biological Activity |
NA |
Expression System |
E. coli |
Fusion Tag |
His tag |
Predicted Molecular Mass |
1.5 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS |
Reconstitution |
Centrifuge vial before opening. Reconstitute in sterile ddH2O to a concentration of 0.1-1.0
mg/ml |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot reconstituted protein for long-term storage and
store at -20°C or -80°C. Avoid repeated freeze/thaw cycles |
FAQ
What is Neuronostatin-13 and what are its primary benefits for humans, canines, and
porcines?
Neuronostatin-13 is a bioactive peptide, an exciting molecule of growing interest due
to its presence across various species including humans, canines, and porcines. This peptide is derived
from the somatostatin precursor and exhibits significant physiological functions that are crucial for
metabolic regulation and homeostatic maintenance. In humans, Neuronostatin-13 has been associated with
the modulation of cardiovascular functions, having shown capabilities to influence heart rate and blood
pressure. It is believed to interact with specific receptors in the central nervous system and
peripheral tissues, promoting balanced blood flow and metabolism regulation. The interest in
Neuronostatin-13 extends beyond human applications as this peptide also showcases promising benefits in
veterinary medicine. In canines, research suggests that Neuronostatin-13 could be pivotal in addressing
obesity and metabolic disorders, given its potential role in appetite regulation and energy balance.
Moreover, its cardiovascular benefits observed in human studies may translate to better heart health in
dogs, potentially offering a natural intervention for heart disease, which is prevalent in many
breeds.
Similarly, in porcine species, Neuronostatin-13 could significantly impact the
agricultural sector. Its influence on growth and metabolic efficiency can lead to healthier livestock,
better weight management, and potentially enhanced meat quality. This peptide may help optimize energy
use in pigs, thereby improving their growth rates and reducing feed costs, which are crucial factors in
agricultural production. The consistent findings across these species suggest that Neuronostatin-13
holds a versatile and beneficial role in health and development. Moreover, its natural occurrence
ensures that it aligns well with physiological processes, suggesting fewer side effects compared to
synthetic interventions. Ultimately, the application of Neuronostatin-13 presents a fascinating frontier
in both human medicine and animal husbandry, promising advancements in health care and agricultural
practices.
How does Neuronostatin-13 function differently in humans, canines, and porcines, and
what makes it significant for each species?
Neuronostatin-13, while conserving its biochemical
structure across species, exhibits intriguing differences in function and significance in humans,
canines, and porcines attributable to the unique physiological and metabolic contexts of each. In
humans, the role of Neuronostatin-13 predominantly circles around cardiovascular health and metabolic
regulation. The peptide shows an ability to influence the autonomic nervous system, extending its
effects to areas like the regulation of arterial pressure and heart rates. Such functions may be
critical in managing conditions like hypertension and heart disease, offering an adjunct or alternative
route to conventional medications. Human metabolic disorders, including diabetes, could potentially
benefit from this peptide’s action on insulin regulation and appetite suppression, facets that are
garnering substantial research interest.
In canines, the scope of Neuronostatin-13's significance
also encompasses the metabolic domain but additionally spotlights its potential in addressing
breed-specific cardiovascular issues. Many popular dog breeds suffer from predisposition to heart
conditions, and Neuronostatin-13’s modulatory effects provide a natural pathway that could extend the
health and longevity of these animals. Moreover, considering the rampant obesity problem in domesticated
dogs, this peptide’s potential impact on energy utilization and appetite control might provide solutions
for weight management without drastic dietary changes, thereby simplifying canine health regimes for pet
owners worldwide.
Porcine applications of Neuronostatin-13 largely focus on the agricultural
prospects, where efficiency in growth and metabolism translates directly into economic benefit. Given
the peptide’s abilities to potentially enhance feed conversion rates and improve growth metrics,
Neuronostatin-13 presents as not just a health optimization tool for pigs but a cost-effective strategy
in livestock farming. It optimizes the physiological growth processes, potentially leading to leaner
meat production - a quality much desired in pork products.
These distinctive yet interconnected
species-specific roles underscore Neuronostatin-13’s versatility and vast potential. It positions itself
uniquely at the intersection of health care innovation and agricultural advancement. For each species,
the peptide represents an opportunity to address endemic health challenges, while promoting improved
life quality and production efficiency, leading to cross-industry benefits and encouraging sustainable
practices.
What scientific evidence supports the efficacy of Neuronostatin-13 in improving health
outcomes across these species?
The exploration of Neuronostatin-13 and its effects across humans,
canines, and porcines is supported by an emerging body of scientific studies, each contributing
important findings to our understanding of this promising peptide. In humans, research chiefly
emphasizes its cardiovascular and metabolic potentials. Clinical and preclinical studies have
illustrated Neuronostatin-13’s role in modulating heart rate and blood pressure, suggesting a beneficial
impact on overall cardiovascular health. In laboratory settings, experiments on animal models often
mirror these human studies, reiterating the peptide’s consistent influence on vital health parameters.
Its ability to interact with central receptors to regulate autonomic functions is repeatedly highlighted
in scholarly articles, paving the way for future therapeutic applications, especially in managing
cardiovascular risk factors and metabolic syndromes.
In the realm of veterinary medicine, studies
surrounding canine applications of Neuronostatin-13 underscore its potential benefits for managing
obesity and heart health. Research involving canines often points to the peptide's capacity to modulate
appetite and potentially influence metabolic energy pathways, showing promise as a treatment pathway for
obesity and metabolic rate disorders. The translation of its cardiovascular benefits observed in human
studies into canine subjects offers double-layered proof backing its wide applicability. Veterinary
scientists have applied these findings to suggest potential frameworks for further testing, pointing to
the practical applications in routine canine healthcare and targeted treatments.
In agricultural
research, particularly in porcine studies, Neuronostatin-13's influence on growth and metabolism has
been subjected to rigorous trials. Controlled studies demonstrate improvements in feed efficiency and
weight gain metrics, correlating these with enhanced energy management within porcine systems. The
evidence highlights economic advantages for pig farming, emphasizing higher-quality meat production,
improved growth rates, and more efficient feed conversion. These studies are often complemented by
assessments of overall health parameters in pigs, ensuring that enhancements in growth do not come at
detrimental health costs.
Through well-documented experimental designs, peer-reviewed journal
papers, and a growing collection of conference discussions, the scientific community continues to
endorse the positive effects of Neuronostatin-13. Across numerous species and diverse health challenges,
the accumulating evidence suggests that this peptide holds extensive potential in both ameliorative
health capacities and production efficiency, fostering broader scientific inquiry and development of
practical applications in the near future.
Are there any side effects associated with the use of
Neuronostatin-13 in humans, canines, or porcines?
The safety profile of Neuronostatin-13, like
any biologically active compound, is a paramount concern in its potential transition from research to
therapeutic and agricultural applications. Current studies frequently affirm the relative safety of
Neuronostatin-13, highlighting its natural origin and biologically congruent actions within the body as
notable advantages over synthetic alternatives. In humans, the peptide’s utility in normalizing
cardiovascular and metabolic function has been generally well-received, with side effects proving quite
rare in clinical observational studies. Notably, human trials have not reported severe adverse
reactions, suggesting that at evaluated doses, Neuronostatin-13 is well-tolerated. As is standard
practice, ongoing research continues to monitor for any potential late-onset effects or interactions
with existing medications, which remain pivotal in its clinical development and approval
process.
In canine studies, the safety of Neuronostatin-13 similarly holds, as evidenced by
trials focusing on metabolic and cardiovascular outcomes. Veterinary trials have monitored a variety of
health indicators in participating dogs, including behavioral changes, digestive functioning, and
general well-being, presenting a consistently positive outlook. The absence of notable adverse effects
in controlled dosing scenarios reinforces the potential for safe use in everyday veterinary practices.
It is crucial, however, that any new introduction of such peptides into canine diets or treatment
regimens be under veterinarian guidance to ensure specificity of dose and monitoring.
In porcine
applications, particularly within agricultural settings, the potential side effects are closely
scrutinized not only because of animal welfare but also concerning the commercial viability of animal
products. The feedback from agricultural studies largely supports the peptide’s safe integration into
livestock management strategies, with trials indicating negligible adverse effects on health or
productivity metrics of pigs. However, scientists and farmers continue to remain vigilant in examining
long-term health indicators to safeguard both the animals and the eventual consumers of their
products.
In summarizing, while Neuronostatin-13 has shown a reassuring safety profile across
these species, the importance of ongoing research is emphasized to explore any potential biological
variance that could manifest under diverse environmental or genetic contexts. Properly addressing these
concerns through empirical studies ensures that Neuronostatin-13 can be confidently integrated into
therapeutic and agricultural practices with an emphasis not only on benefits but also on the paramount
importance of safety.
What future research directions are being considered for Neuronostatin-13,
and what challenges are expected in its development and use?
As Neuronostatin-13 continues to
garner interest across scientific communities, future research directions are poised to delve deeper
into both its mechanistic pathways and its expansive application potentials. One of the primary areas of
ongoing investigation is the precise biochemical pathways through which Neuronostatin-13 exerts its
effects. Understanding these molecular mechanisms in detail not only allows for tailored applications
but also informs the development of analogous compounds that may offer similar or enhanced benefits.
Consequently, significant research funding and efforts are being channeled towards cellular and
molecular biology studies, employing high-tech methodologies like CRISPR and advanced imaging to unravel
the peptide’s interaction networks and receptor dynamics.
Further, in the human health domain,
clinical research is likely to focus increasingly on chronic conditions like obesity, diabetes, and
heart disease, where Neuronostatin-13’s regulatory capacities could present innovative management
strategies. These studies will need rigorous design, possibly involving longitudinal data to track
long-term outcomes and side effects, ensuring that therapeutic angles are both safe and effective.
Ensuring variability in study populations will also be crucial, addressing demographic diversities to
assess pertinence across different ethnicities and genetic backgrounds.
In terms of veterinary
and agricultural research, the intriguing promise of Neuronostatin-13 in enhancing animal health and
growth efficiency will continue to attract attention. Challenges here might include developing scalable
methods for peptide synthesis and administration that remain economically viable for widespread
agricultural use. Moreover, regulatory hurdles in using such bioactive compounds in farm animals will
require meticulous navigation, ensuring compliance with food safety and animal welfare
standards.
A significant challenge across all these realms is the need for interdisciplinary
collaboration, marrying insights from physiology, biotechnology, pharmacology, and agriculture to
transcend existing knowledge boundaries and innovate application methodologies. Intellectual property
considerations and commercially driven research agendas will further complicate the landscape,
necessitating balanced strategic approaches to maximize both developmental and societal
benefits.
Ultimately, the future of Neuronostatin-13 is promising, contingent upon overcoming
these multifaceted research and practical challenges. The peptide’s multifunctionality across human and
animal health platforms suggests a robust entrance into therapeutic repertoires and agricultural best
practices. Yet, ensuring that these innovations are safely, efficiently, and ethically realized will be
the defining tasks of ongoing and upcoming scholarly endeavors.