Taiy Chemical
Proinsulin C-Peptide (55-89) (human)
Synonym Proinsulin C-peptide (55-89) (human)
Species Human
Protein Accession Q5SW42
Purity > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity Not specified
Expression System E. coli
Fusion Tag No tag
Predicted Molecular Mass Approximately 4.8 kDa
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0
Reconstitution It is recommended to reconstitute the lyophilized Proinsulin C-Peptide (55-89) in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage & Stability Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freeze-thaw cycles. Once reconstituted, the protein may be stored at 4°C in the short term. For long-term storage, it is recommended to store at -20°C.
FAQ
What is Proinsulin C-Peptide (55-89) (human) and why is it important?

Proinsulin C-Peptide (55-89) (human) is a peptide component that plays a crucial role in the insulin synthesis pathway. It is a segment of the proinsulin molecule that is excised to produce insulin, an essential hormone that regulates blood glucose levels. Beyond its role in insulin synthesis, the C-Peptide possesses intrinsic biological activity that has garnered interest for its potential therapeutic benefits. Researchers have recognized its significance in addressing physiological conditions related to diabetes and neuropathies, beauty, and general wellness. This particular sequence, C-Peptide (55-89), corresponds to a specific portion of the proinsulin C-peptide, composed of amino acids 55 to 89, and is identical to the human version found in the body.

The importance of Proinsulin C-Peptide (55-89) (human) stems from its multifaceted role in the body. It has been observed to have a direct impact on several cellular and physiological processes. Studies suggest that the C-Peptide can enhance microvascular blood flow, improving circulatory function and oxygen delivery at the cellular level. Such capacities make it potentially beneficial in treating conditions involving impaired microcirculation that often accompany diabetes, such as diabetic neuropathy. It may also exert protective actions against nerve damage, and thus it is being studied for its neuroprotective effects.

Moreover, the biological actions of the C-Peptide extend to inhibiting inflammatory processes and reducing oxidative stress, both of which are critical in managing chronic conditions. The exact mechanism through which C-Peptide exerts these effects is still under study, yet its role in modulating cellular processes highlights its therapeutic potential. Research is ongoing to fully understand how best to harness the power of Proinsulin C-Peptide (55-89) for clinical applications and to explore any potential contraindications. This compound is not only a piece of the puzzle in understanding diabetes but also in uncovering broader applications for health and disease prevention.

How is Proinsulin C-Peptide (55-89) (human) different from other peptide supplements?

Proinsulin C-Peptide (55-89) (human) is distinct from other peptide supplements due to its specific physiological roles and effects. Unlike generic peptide blends aimed at improving overall wellness or muscle growth like those often found in the fitness industry, the C-Peptide focuses on insulin pathways and has implications far beyond muscle protein synthesis. It is synthesized to mirror the exact sequence found in human proinsulin, making it compatible with the body’s biological systems without causing immune reactions or incompatibility issues.

A critical differentiation is the type and specificity of action. Most common peptide supplements impact the system generalistically, such as by promoting muscle growth or skin elasticity. However, C-Peptide (55-89) targets areas related to glucose metabolism, nerve health, and vasodilation. Its action is notably significant for diabetic patients or those with conditions related to insulin resistance because it directly engages with how the body processes insulin. Further distinctions stem from its neuroprotective and microcirculatory activities, which are less common in traditional peptide supplements.

Additionally, research suggests that Proinsulin C-Peptide (55-89) may help mitigate diabetic complications, such as neuropathy, by interacting with cell receptors differently than non-specific peptides. This specificity grants it a unique position both in research and potential clinical settings. The structural integrity and functional aspects of C-Peptide (55-89) are preserved to serve health conditions without significant interference in unrelated physiological pathways, providing a more targeted therapeutic benefit.

Furthermore, due to its targeted mechanism of action, administering Proinsulin C-Peptide (55-89) requires careful consideration of dosage and monitoring, especially in clinical trials or therapeutic interventions. This specificity is lessened in broader use peptide supplements that often possess a catch-all approach with less focused health goals. Ultimately, the unique qualities of Proinsulin C-Peptide (55-89) (human) render it an instrument of specific medical interest rather than a general wellness supplement, with ongoing studies designed to explore its broader clinical applications.

Who should consider using Proinsulin C-Peptide (55-89) (human)?

Individuals with specific health needs may benefit from considering Proinsulin C-Peptide (55-89) (human). Primarily, it is aimed at people experiencing issues related to insulin production and regulation, such as those with type 1 or type 2 diabetes. Diabetes impacts millions of individuals worldwide, and managing blood glucose levels effectively can be challenging. C-Peptide (55-89), with its ability to enhance insulin activity and improve vascular health, holds promise for these patients as part of a comprehensive treatment plan.

People experiencing diabetic neuropathy might also consider this due to the peptide’s potential neuroprotective properties. Neuropathy, characterized by nerve damage most often seen in diabetics, results in symptoms like pain, tingling, and numbness, predominantly in the extremities. Proinsulin C-Peptide (55-89) (human) shows potential in addressing this by improving nerve function and reducing neuropathic pain through improved microvascular blood flow and cellular repair processes.

Moreover, the supplement could also appeal to those seeking neuroprotective or anti-inflammatory effects not directly related to diabetes. Research suggests it may play a role in reducing oxidative stress and inflammation across various tissues, which could prove significant for individuals with chronic inflammatory conditions. By limiting oxidative damage, C-Peptide could contribute to overall cellular health and longevity while playing a supportive role in conditions characterized by chronic inflammation.

However, due to its specific action and target audience, individuals falling outside these categories should not consider using it without specific guidance regarding their health needs. Those with a metabolic interest due to non-diabetic purposes such as metabolic syndrome management or targeted health optimization can discuss with their healthcare provider about its possible benefits and suitability.

It's also essential for individuals considering Proinsulin C-Peptide (55-89) to consult healthcare professionals before beginning. This ensures that the personal health history and any potential contraindications are thoroughly evaluated. Ensuring medical guidance is paramount, as current research still seeks to define the best avenues and safety parameters for its decentralized applications. Given these nuances, while Proinsulin C-Peptide (55-89) (human) holds therapeutic possibility for specific situations, engaging with a healthcare provider will delineate its place within the individual’s holistic treatment approach.

What are the potential benefits of using Proinsulin C-Peptide (55-89) (human)?

Proinsulin C-Peptide (55-89) (human) presents various potential benefits that make it an intriguing subject of study and interest for those dealing with specific health concerns, particularly related to glucose metabolism and neuropathic conditions. One of the primary benefits lies in its ability to enhance microvascular blood flow. By doing so, C-Peptide improves oxygen delivery and nutrient supply to tissues, which is especially beneficial in peripheral tissues often affected by diabetic complications. Improved microcirculation can lead to better general tissue health and recovery, reducing the risk of aggravated diabetic neuropathy.

Additionally, the peptide has demonstrated neuroprotective properties. For those with diabetes, protecting nerve function is a significant concern due to the risk of diabetic neuropathy. C-Peptide (55-89) has been studied for its potential to enhance nerve conduction velocity and nerve regeneration, offering a way to alleviate symptoms like numbness and pain associated with neuropathic damage. Its role in neuromodulation could provide relief by preserving nerve fibers and promoting healing mechanisms within the nervous system.

Another promising benefit is its anti-inflammatory properties. The peptide may inhibit the onset of inflammatory processes, which is crucial as chronic inflammation is a contributing factor to a wide array of health conditions, including cardiovascular diseases, autoimmune disorders, and diabetes itself. By minimizing inflammation, C-Peptide could contribute to mitigating these risks and promoting overall health resilience.

Proinsulin C-Peptide (55-89) has shown effectiveness in reducing oxidative stress. Oxidative stress results from an imbalance between free radicals and antioxidants, often leading to cellular damage. The antioxidant effect of C-Peptide can protect the body's cells from damage and support the repair of tissues, offering a prophylactic edge against degenerative diseases.

Yet, it's essential to highlight that while potential benefits are promising, Proinsulin C-Peptide (55-89) (human) is still often considered experimental in many scenarios outside of controlled therapeutic use. More comprehensive clinical trials are needed to confirm these benefits across broader populations definitively. Researchers continue to explore optimal dosing, safety profiles, and long-term effects to fully harness the benefits of this peptide.

Are there any known side effects or considerations when using Proinsulin C-Peptide (55-89) (human)?

As with many compounds researched within therapeutic realms, it is vital to consider both the benefits and potential side effects or considerations of using Proinsulin C-Peptide (55-89) (human). Current research has not identified significant adverse effects, making it a generally safe peptide under controlled conditions. However, since its application is often associated with individuals managing diabetes or related metabolic issues, medical discretion is advised.

A primary consideration should be the potential interactions with existing diabetes medications. Individuals utilizing insulin or other glucose-regulating drugs must manage blood sugar levels vigilantly when starting any new supplement, including Proinsulin C-Peptide (55-89). While uncommon, there could be possible interactions affecting blood glucose control due to enhanced insulin activity. Consulting healthcare professionals ensures these levels remain within optimal ranges while adjusting to any supplemental regimen that includes the peptide.

Furthermore, as with any peptide-based application, allergic reactions, although rare, can occur. Such reactions can range from mild symptoms like localized skin irritation to, in exceptional cases, more systemic responses. Initial users of Proinsulin C-Peptide should monitor for any indicative signs of allergies, especially during the early stages of administration, and cease use upon observing any adverse reactions.

Another consideration involves understanding the source and quality of the peptide. It is crucial that Proinsulin C-Peptide (55-89) is sourced through reputable, scientifically validated channels to ensure the highest standard of purity and efficacy. Misrepresented products might not only diminish the anticipated benefits but could also introduce unexpected side effects due to impurities or incorrect formulations.

Moreover, despite its favorable safety profile indicated in studies, users should be mindful of individual variability. Physiological differences mean that responses to the peptide may not be uniform across all users. Continued research aims to better predict these variations, making consultations with healthcare providers or specialists in metabolic disorders of paramount importance before beginning any new treatment protocol with Proinsulin C-Peptide (55-89).

In conclusion, while the peptide shows great therapeutic promise, its incorporation should be carefully monitored within personalized medical frameworks. This ensures not only the maximization of its potential benefits but also minimizes any unforeseen side effects, reflecting a balanced approach to new therapeutic avenues for those in need of closely managed glucose and nerve condition treatments.
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