Synonym |
Proinsulin C-peptide (55-89) (human) |
Species |
Human |
Protein Accession |
Q5SW42 |
Purity |
> 95% |
Endotoxin Level |
< 1.0 EU per 1 μg of protein |
Biological Activity |
Not specified |
Expression System |
E. coli |
Fusion Tag |
No tag |
Predicted Molecular Mass |
Approximately 4.8 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0 |
Reconstitution |
It is recommended to reconstitute the lyophilized Proinsulin C-Peptide (55-89) in sterile
18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous
solutions. |
Storage & Stability |
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated
freeze-thaw cycles. Once reconstituted, the protein may be stored at 4°C in the short term. For
long-term storage, it is recommended to store at -20°C. |
FAQ
What is Proinsulin C-Peptide (55-89) (human) and why is it important?
Proinsulin C-Peptide
(55-89) (human) is a peptide component that plays a crucial role in the insulin synthesis pathway. It is
a segment of the proinsulin molecule that is excised to produce insulin, an essential hormone that
regulates blood glucose levels. Beyond its role in insulin synthesis, the C-Peptide possesses intrinsic
biological activity that has garnered interest for its potential therapeutic benefits. Researchers have
recognized its significance in addressing physiological conditions related to diabetes and neuropathies,
beauty, and general wellness. This particular sequence, C-Peptide (55-89), corresponds to a specific
portion of the proinsulin C-peptide, composed of amino acids 55 to 89, and is identical to the human
version found in the body.
The importance of Proinsulin C-Peptide (55-89) (human) stems from its
multifaceted role in the body. It has been observed to have a direct impact on several cellular and
physiological processes. Studies suggest that the C-Peptide can enhance microvascular blood flow,
improving circulatory function and oxygen delivery at the cellular level. Such capacities make it
potentially beneficial in treating conditions involving impaired microcirculation that often accompany
diabetes, such as diabetic neuropathy. It may also exert protective actions against nerve damage, and
thus it is being studied for its neuroprotective effects.
Moreover, the biological actions of the
C-Peptide extend to inhibiting inflammatory processes and reducing oxidative stress, both of which are
critical in managing chronic conditions. The exact mechanism through which C-Peptide exerts these
effects is still under study, yet its role in modulating cellular processes highlights its therapeutic
potential. Research is ongoing to fully understand how best to harness the power of Proinsulin C-Peptide
(55-89) for clinical applications and to explore any potential contraindications. This compound is not
only a piece of the puzzle in understanding diabetes but also in uncovering broader applications for
health and disease prevention.
How is Proinsulin C-Peptide (55-89) (human) different from other
peptide supplements?
Proinsulin C-Peptide (55-89) (human) is distinct from other peptide
supplements due to its specific physiological roles and effects. Unlike generic peptide blends aimed at
improving overall wellness or muscle growth like those often found in the fitness industry, the
C-Peptide focuses on insulin pathways and has implications far beyond muscle protein synthesis. It is
synthesized to mirror the exact sequence found in human proinsulin, making it compatible with the body’s
biological systems without causing immune reactions or incompatibility issues.
A critical
differentiation is the type and specificity of action. Most common peptide supplements impact the system
generalistically, such as by promoting muscle growth or skin elasticity. However, C-Peptide (55-89)
targets areas related to glucose metabolism, nerve health, and vasodilation. Its action is notably
significant for diabetic patients or those with conditions related to insulin resistance because it
directly engages with how the body processes insulin. Further distinctions stem from its neuroprotective
and microcirculatory activities, which are less common in traditional peptide
supplements.
Additionally, research suggests that Proinsulin C-Peptide (55-89) may help mitigate
diabetic complications, such as neuropathy, by interacting with cell receptors differently than
non-specific peptides. This specificity grants it a unique position both in research and potential
clinical settings. The structural integrity and functional aspects of C-Peptide (55-89) are preserved to
serve health conditions without significant interference in unrelated physiological pathways, providing
a more targeted therapeutic benefit.
Furthermore, due to its targeted mechanism of action,
administering Proinsulin C-Peptide (55-89) requires careful consideration of dosage and monitoring,
especially in clinical trials or therapeutic interventions. This specificity is lessened in broader use
peptide supplements that often possess a catch-all approach with less focused health goals. Ultimately,
the unique qualities of Proinsulin C-Peptide (55-89) (human) render it an instrument of specific medical
interest rather than a general wellness supplement, with ongoing studies designed to explore its broader
clinical applications.
Who should consider using Proinsulin C-Peptide (55-89)
(human)?
Individuals with specific health needs may benefit from considering Proinsulin C-Peptide
(55-89) (human). Primarily, it is aimed at people experiencing issues related to insulin production and
regulation, such as those with type 1 or type 2 diabetes. Diabetes impacts millions of individuals
worldwide, and managing blood glucose levels effectively can be challenging. C-Peptide (55-89), with its
ability to enhance insulin activity and improve vascular health, holds promise for these patients as
part of a comprehensive treatment plan.
People experiencing diabetic neuropathy might also
consider this due to the peptide’s potential neuroprotective properties. Neuropathy, characterized by
nerve damage most often seen in diabetics, results in symptoms like pain, tingling, and numbness,
predominantly in the extremities. Proinsulin C-Peptide (55-89) (human) shows potential in addressing
this by improving nerve function and reducing neuropathic pain through improved microvascular blood flow
and cellular repair processes.
Moreover, the supplement could also appeal to those seeking
neuroprotective or anti-inflammatory effects not directly related to diabetes. Research suggests it may
play a role in reducing oxidative stress and inflammation across various tissues, which could prove
significant for individuals with chronic inflammatory conditions. By limiting oxidative damage,
C-Peptide could contribute to overall cellular health and longevity while playing a supportive role in
conditions characterized by chronic inflammation.
However, due to its specific action and target
audience, individuals falling outside these categories should not consider using it without specific
guidance regarding their health needs. Those with a metabolic interest due to non-diabetic purposes such
as metabolic syndrome management or targeted health optimization can discuss with their healthcare
provider about its possible benefits and suitability.
It's also essential for individuals
considering Proinsulin C-Peptide (55-89) to consult healthcare professionals before beginning. This
ensures that the personal health history and any potential contraindications are thoroughly evaluated.
Ensuring medical guidance is paramount, as current research still seeks to define the best avenues and
safety parameters for its decentralized applications. Given these nuances, while Proinsulin C-Peptide
(55-89) (human) holds therapeutic possibility for specific situations, engaging with a healthcare
provider will delineate its place within the individual’s holistic treatment approach.
What are
the potential benefits of using Proinsulin C-Peptide (55-89) (human)?
Proinsulin C-Peptide
(55-89) (human) presents various potential benefits that make it an intriguing subject of study and
interest for those dealing with specific health concerns, particularly related to glucose metabolism and
neuropathic conditions. One of the primary benefits lies in its ability to enhance microvascular blood
flow. By doing so, C-Peptide improves oxygen delivery and nutrient supply to tissues, which is
especially beneficial in peripheral tissues often affected by diabetic complications. Improved
microcirculation can lead to better general tissue health and recovery, reducing the risk of aggravated
diabetic neuropathy.
Additionally, the peptide has demonstrated neuroprotective properties. For
those with diabetes, protecting nerve function is a significant concern due to the risk of diabetic
neuropathy. C-Peptide (55-89) has been studied for its potential to enhance nerve conduction velocity
and nerve regeneration, offering a way to alleviate symptoms like numbness and pain associated with
neuropathic damage. Its role in neuromodulation could provide relief by preserving nerve fibers and
promoting healing mechanisms within the nervous system.
Another promising benefit is its
anti-inflammatory properties. The peptide may inhibit the onset of inflammatory processes, which is
crucial as chronic inflammation is a contributing factor to a wide array of health conditions, including
cardiovascular diseases, autoimmune disorders, and diabetes itself. By minimizing inflammation,
C-Peptide could contribute to mitigating these risks and promoting overall health
resilience.
Proinsulin C-Peptide (55-89) has shown effectiveness in reducing oxidative stress.
Oxidative stress results from an imbalance between free radicals and antioxidants, often leading to
cellular damage. The antioxidant effect of C-Peptide can protect the body's cells from damage and
support the repair of tissues, offering a prophylactic edge against degenerative diseases.
Yet,
it's essential to highlight that while potential benefits are promising, Proinsulin C-Peptide (55-89)
(human) is still often considered experimental in many scenarios outside of controlled therapeutic use.
More comprehensive clinical trials are needed to confirm these benefits across broader populations
definitively. Researchers continue to explore optimal dosing, safety profiles, and long-term effects to
fully harness the benefits of this peptide.
Are there any known side effects or considerations
when using Proinsulin C-Peptide (55-89) (human)?
As with many compounds researched within
therapeutic realms, it is vital to consider both the benefits and potential side effects or
considerations of using Proinsulin C-Peptide (55-89) (human). Current research has not identified
significant adverse effects, making it a generally safe peptide under controlled conditions. However,
since its application is often associated with individuals managing diabetes or related metabolic
issues, medical discretion is advised.
A primary consideration should be the potential
interactions with existing diabetes medications. Individuals utilizing insulin or other
glucose-regulating drugs must manage blood sugar levels vigilantly when starting any new supplement,
including Proinsulin C-Peptide (55-89). While uncommon, there could be possible interactions affecting
blood glucose control due to enhanced insulin activity. Consulting healthcare professionals ensures
these levels remain within optimal ranges while adjusting to any supplemental regimen that includes the
peptide.
Furthermore, as with any peptide-based application, allergic reactions, although rare,
can occur. Such reactions can range from mild symptoms like localized skin irritation to, in exceptional
cases, more systemic responses. Initial users of Proinsulin C-Peptide should monitor for any indicative
signs of allergies, especially during the early stages of administration, and cease use upon observing
any adverse reactions.
Another consideration involves understanding the source and quality of the
peptide. It is crucial that Proinsulin C-Peptide (55-89) is sourced through reputable, scientifically
validated channels to ensure the highest standard of purity and efficacy. Misrepresented products might
not only diminish the anticipated benefits but could also introduce unexpected side effects due to
impurities or incorrect formulations.
Moreover, despite its favorable safety profile indicated in
studies, users should be mindful of individual variability. Physiological differences mean that
responses to the peptide may not be uniform across all users. Continued research aims to better predict
these variations, making consultations with healthcare providers or specialists in metabolic disorders
of paramount importance before beginning any new treatment protocol with Proinsulin C-Peptide
(55-89).
In conclusion, while the peptide shows great therapeutic promise, its incorporation
should be carefully monitored within personalized medical frameworks. This ensures not only the
maximization of its potential benefits but also minimizes any unforeseen side effects, reflecting a
balanced approach to new therapeutic avenues for those in need of closely managed glucose and nerve
condition treatments.