Taiy Chemical
Stresscopin-Related Peptide (human)
Synonym Cortistatin-14
Species Human
Protein Accession Q16631
Purity Greater than 95% as determined by SEC-HPLC
Endotoxin Level Less than 1 EU/μg
Biological Activity Not specified
Expression System E. coli
Fusion Tag None
Predicted Molecular Mass 1.6 kDa
Formulation Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA
Reconstitution Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Storage & Stability Store at -20°C. Aliquot and store at -20°C or -80°C for long term storage. Avoid repeated freeze-thaw cycles.
FAQ
What is the Stresscopin-Related Peptide (human), and how is it relevant to scientific research?
Stresscopin-Related Peptide (human) refers to a specific peptide with a unique sequence that is closely associated with urocortins, playing a crucial role in the physiological processes of stress response and immune regulation. This peptide is of significant interest in scientific research due to its involvement in the modulation of various stress-related pathways and its potential therapeutic applications. As a member of the corticotrophin-releasing factor (CRF) family of peptides, it is recognized for its capacity to interact with specific receptors like CRF type 2 receptor, making it instrumental in stress and anxiety management. Understanding the underlying mechanisms of how the Stresscopin-Related Peptide operates can unveil therapeutic possibilities for conditions such as depression, anxiety disorders, and other stress-related ailments. Moreover, its influence on immune system functioning makes it valuable in exploring new treatments for autoimmune diseases and inflammatory disorders. Researchers are also investigating the peptide's role in cardiovascular functions, thus opening pathways for developing heart-related treatments. The exploration of this peptide's impact on the human body's various systems emphasizes its relevance in biomedicine and therapeutic drug development. The complexity of its interactions and effects exemplifies the importance of this peptide in advancing medical research, helping to devise new strategies for disease treatment and management.

What are the physiological roles of the Stresscopin-Related Peptide (human) in the body?
Stresscopin-Related Peptide (human) plays a multifaceted role in regulating physiological processes linked to stress, mood, immune response, and cardiovascular functions. Primarily, this peptide is involved in the body's stress response by interacting with CRF receptors, particularly type 2, which are known to mitigate stress-related symptoms like anxiety and depression. These interactions can modulate the hypothalamus-pituitary-adrenal (HPA) axis, crucial in controlling numerous body processes, including mood regulation, stress response, and immune system functioning. By influencing these receptors, Stresscopin-Related Peptide helps maintain equilibrium and resilience against stress, making it crucial for mental health stability. Additionally, this peptide exerts influence over immune responses, suggesting a potential role in moderating inflammatory and autoimmune conditions. Its presence in various body tissues, including cardiac tissues, indicates that it may significantly affect cardiovascular health by regulating heart rate and blood pressure, thus implicating it in research related to hypertension and heart disease. Furthermore, by elucidating its comprehensive functions and mechanisms, the Stresscopin-Related Peptide offers potential therapeutic avenues for disorders related to stress, anxiety, and other physiological systems it influences, emphasizing its significance in developing new medical treatments.

How might Stresscopin-Related Peptide (human) contribute to the development of new therapeutic approaches?
The therapeutic potential of Stresscopin-Related Peptide (human) emerges from its ability to regulate several physiological functions, particularly stress response, immune regulation, and cardiovascular health. Enhancing our understanding of these pathways provides insight into innovative treatments for diverse medical conditions. In the realm of mental health, the peptide's interaction with CRF receptors involved in stress and anxiety management is pivotal. By targeting these receptors, new therapeutic agents could be developed to combat anxiety disorders, depression, and other stress-related illnesses. Research into the precise mechanisms by which Stresscopin-Related Peptide modulates the HPA axis could lead to novel interventions aimed at restoring balance in individuals with dysregulated stress responses. Similarly, the peptide's role in immune regulation offers potential pathways to treat inflammatory and autoimmune diseases. Modulating immune functions can aid in alleviating symptoms and halting the progression of such disorders. Cardiovascular research may also benefit, as the peptide's influence on heart rate and blood pressure presents opportunities for developing treatments for hypertension and heart-related conditions. Advancements in peptide-based therapeutics could pave the way for customized medical solutions tailored to specific biological pathways influenced by Stresscopin-Related Peptide, enhancing outcomes for patients across various medical fields.

Are there challenges associated with researching Stresscopin-Related Peptide (human)?
Researching Stresscopin-Related Peptide (human) involves several challenges, primarily due to its complex interactions in the human body. One significant hurdle is the intricate nature of peptide and receptor interactions and the downstream signaling pathways they trigger. Understanding these complex networks requires advanced methodologies and tools, which can be resource-intensive and time-consuming. Additionally, the peptide's broad physiological roles mean that any modulation could potentially lead to unintended side effects in unrelated systems. This necessitates extensive studies to delineate its specific functions and effects clearly. Another challenge is the need for high specificity in targeting CRF receptors while avoiding cross-reactivity with other similar receptors, which demands the development of highly selective agents. Moreover, translating findings from animal models to humans presents further complexity due to physiological differences, necessitating comprehensive clinical testing to ensure safety and efficacy. Lastly, the nascent stage of peptide-based therapeutics research means that regulatory and production challenges could also arise as new drugs are developed. Overcoming these challenges requires collaborative efforts across disciplines and technological advancements, crucial for unlocking the full potential of therapeutic interventions based on Stresscopin-Related Peptide.

How does the Stresscopin-Related Peptide (human) interact with the CRF receptor family?
Stresscopin-Related Peptide (human) interacts primarily with the CRF receptor family, particularly the type 2 receptor, modulating various physiological processes. The CRF receptors are part of the G protein-coupled receptor family, known for their role in mediating stress and anxiety responses. The interaction between Stresscopin-Related Peptide and CRF receptors initiates a cascade of intracellular events, influencing pathways like the HPA axis. This modulation is crucial for maintaining homeostasis during stress, as it can alter the release of cortisol and other stress-related hormones. By binding to CRF type 2 receptors, the peptide helps regulate stress-induced responses, mitigating anxiety and depression symptoms. These receptors are prevalent in brain regions associated with emotional and stress responses, indicating their medial role in mental health. Additionally, peripheral CRF receptors also guide cardiovascular and immune regulation, reflecting the peptide's broader physiological significance. Understanding these interactions provides valuable insights into developing CRF receptor-specific therapies that harness the beneficial effects of Stresscopin-Related Peptide while minimizing undesired consequences. By dissecting these intricate receptor-peptide interactions, researchers can devise strategies to modulate these pathways therapeutically, addressing a range of physical and mental health conditions.
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