Synonym |
Cortistatin-14 |
Species |
Human |
Protein Accession |
Q16631 |
Purity |
Greater than 95% as determined by SEC-HPLC |
Endotoxin Level |
Less than 1 EU/μg |
Biological Activity |
Not specified |
Expression System |
E. coli |
Fusion Tag |
None |
Predicted Molecular Mass |
1.6 kDa |
Formulation |
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA |
Reconstitution |
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Do not vortex. |
Storage & Stability |
Store at -20°C. Aliquot and store at -20°C or -80°C for long term storage. Avoid repeated
freeze-thaw cycles. |
FAQ
What is the Stresscopin-Related Peptide (human), and how is it relevant to scientific research?
Stresscopin-Related Peptide (human) refers to a specific peptide with a unique sequence that is
closely associated with urocortins, playing a crucial role in the physiological processes of stress
response and immune regulation. This peptide is of significant interest in scientific research due to
its involvement in the modulation of various stress-related pathways and its potential therapeutic
applications. As a member of the corticotrophin-releasing factor (CRF) family of peptides, it is
recognized for its capacity to interact with specific receptors like CRF type 2 receptor, making it
instrumental in stress and anxiety management. Understanding the underlying mechanisms of how the
Stresscopin-Related Peptide operates can unveil therapeutic possibilities for conditions such as
depression, anxiety disorders, and other stress-related ailments. Moreover, its influence on immune
system functioning makes it valuable in exploring new treatments for autoimmune diseases and
inflammatory disorders. Researchers are also investigating the peptide's role in cardiovascular
functions, thus opening pathways for developing heart-related treatments. The exploration of this
peptide's impact on the human body's various systems emphasizes its relevance in biomedicine and
therapeutic drug development. The complexity of its interactions and effects exemplifies the importance
of this peptide in advancing medical research, helping to devise new strategies for disease treatment
and management.
What are the physiological roles of the Stresscopin-Related Peptide (human) in
the body?
Stresscopin-Related Peptide (human) plays a multifaceted role in regulating physiological
processes linked to stress, mood, immune response, and cardiovascular functions. Primarily, this peptide
is involved in the body's stress response by interacting with CRF receptors, particularly type 2, which
are known to mitigate stress-related symptoms like anxiety and depression. These interactions can
modulate the hypothalamus-pituitary-adrenal (HPA) axis, crucial in controlling numerous body processes,
including mood regulation, stress response, and immune system functioning. By influencing these
receptors, Stresscopin-Related Peptide helps maintain equilibrium and resilience against stress, making
it crucial for mental health stability. Additionally, this peptide exerts influence over immune
responses, suggesting a potential role in moderating inflammatory and autoimmune conditions. Its
presence in various body tissues, including cardiac tissues, indicates that it may significantly affect
cardiovascular health by regulating heart rate and blood pressure, thus implicating it in research
related to hypertension and heart disease. Furthermore, by elucidating its comprehensive functions and
mechanisms, the Stresscopin-Related Peptide offers potential therapeutic avenues for disorders related
to stress, anxiety, and other physiological systems it influences, emphasizing its significance in
developing new medical treatments.
How might Stresscopin-Related Peptide (human) contribute to
the development of new therapeutic approaches?
The therapeutic potential of Stresscopin-Related
Peptide (human) emerges from its ability to regulate several physiological functions, particularly
stress response, immune regulation, and cardiovascular health. Enhancing our understanding of these
pathways provides insight into innovative treatments for diverse medical conditions. In the realm of
mental health, the peptide's interaction with CRF receptors involved in stress and anxiety management is
pivotal. By targeting these receptors, new therapeutic agents could be developed to combat anxiety
disorders, depression, and other stress-related illnesses. Research into the precise mechanisms by which
Stresscopin-Related Peptide modulates the HPA axis could lead to novel interventions aimed at restoring
balance in individuals with dysregulated stress responses. Similarly, the peptide's role in immune
regulation offers potential pathways to treat inflammatory and autoimmune diseases. Modulating immune
functions can aid in alleviating symptoms and halting the progression of such disorders. Cardiovascular
research may also benefit, as the peptide's influence on heart rate and blood pressure presents
opportunities for developing treatments for hypertension and heart-related conditions. Advancements in
peptide-based therapeutics could pave the way for customized medical solutions tailored to specific
biological pathways influenced by Stresscopin-Related Peptide, enhancing outcomes for patients across
various medical fields.
Are there challenges associated with researching Stresscopin-Related
Peptide (human)?
Researching Stresscopin-Related Peptide (human) involves several challenges,
primarily due to its complex interactions in the human body. One significant hurdle is the intricate
nature of peptide and receptor interactions and the downstream signaling pathways they trigger.
Understanding these complex networks requires advanced methodologies and tools, which can be
resource-intensive and time-consuming. Additionally, the peptide's broad physiological roles mean that
any modulation could potentially lead to unintended side effects in unrelated systems. This necessitates
extensive studies to delineate its specific functions and effects clearly. Another challenge is the need
for high specificity in targeting CRF receptors while avoiding cross-reactivity with other similar
receptors, which demands the development of highly selective agents. Moreover, translating findings from
animal models to humans presents further complexity due to physiological differences, necessitating
comprehensive clinical testing to ensure safety and efficacy. Lastly, the nascent stage of peptide-based
therapeutics research means that regulatory and production challenges could also arise as new drugs are
developed. Overcoming these challenges requires collaborative efforts across disciplines and
technological advancements, crucial for unlocking the full potential of therapeutic interventions based
on Stresscopin-Related Peptide.
How does the Stresscopin-Related Peptide (human) interact with
the CRF receptor family?
Stresscopin-Related Peptide (human) interacts primarily with the CRF
receptor family, particularly the type 2 receptor, modulating various physiological processes. The CRF
receptors are part of the G protein-coupled receptor family, known for their role in mediating stress
and anxiety responses. The interaction between Stresscopin-Related Peptide and CRF receptors initiates a
cascade of intracellular events, influencing pathways like the HPA axis. This modulation is crucial for
maintaining homeostasis during stress, as it can alter the release of cortisol and other stress-related
hormones. By binding to CRF type 2 receptors, the peptide helps regulate stress-induced responses,
mitigating anxiety and depression symptoms. These receptors are prevalent in brain regions associated
with emotional and stress responses, indicating their medial role in mental health. Additionally,
peripheral CRF receptors also guide cardiovascular and immune regulation, reflecting the peptide's
broader physiological significance. Understanding these interactions provides valuable insights into
developing CRF receptor-specific therapies that harness the beneficial effects of Stresscopin-Related
Peptide while minimizing undesired consequences. By dissecting these intricate receptor-peptide
interactions, researchers can devise strategies to modulate these pathways therapeutically, addressing a
range of physical and mental health conditions.